Yep.

Agreed, exactly why the hubris displayed was annoying. A lot of fanfare for a very modest advantage of a stereoisomer over a racemate.

I too have been surprised by the NIMH hubris regarding S-ketamine. Important to note that the potency difference between R(-) and S(+) is only about 8-fold (Mol Pharmacol 41, 134, 1992).

He cannot get past his being wrong about COVID and his flawed Santa Clara study. Poor sensitive guy.

Agreed it is tangled, but manageable. I dropped to a 0.5FTE to teach med students. This avoided potential cold turkey. Unforeseen benefit is that teaching has improved due to adequate time to prepare for lectures!

I don't understand the need for a tapered funding as a component of a planned retirement. I planned and closed my lab in 2020 after decades of NIH funding. Planning avoided negative impact for all lab personnel (students, postdocs, technicians).

47 year old REI summit parka purchased when there was only 1 REI store.

RIP Nancy Zahniser

28.5% of the population in Lexington, NE have lost their jobs. This likely represents the majority of jobs in Lexington.

The most popular over-the-counter cough suppressant is a psychedelic drug Dextromethorphan is an NMDA receptor antagonist, like ketamine

The most popular over-the-counter cough suppressant is a psychedelic drug
open.substack.com/pub/higherpl...

Many thanks for this thread and analysis. I don't fully understand why the forward funding creates future reductions in budget and new awards.

Not really: Focus on Official Names: The NIH Enterprise Directory (NED) has undergone updates, removing the ability for employees to enter or modify preferred names (nicknames) and clearing previously entered ones.

NIH: The quiet engine of science is being dismantled And what you can do

NIH: The quiet engine of science is being dismantled open.substack.com/pub/yourloca... Great summary of current threats to research.

Vaping etomidate (“Space Oil”) has become a thing Do we actually understand the endocrine effects of etomidate?

Vaping etomidate (“Space Oil”) has become a thing open.substack.com/pub/higherpl... New GABAergic substance use story.

Your Grant in Review: Virtual Meetings I have reviewed grants for NIH with study sections that meet in person, sections that meet via video conferencing and sections that use an online forum approach. The latter is sometimes call &#8220…

Your Grant in Review: Virtual Meetings drugmonkey.wordpress.com/2025/04/11/y... I had a non-CSR study section Zoom meeting in March delayed and now switched to an asynchronous format for May. This definitely reduces quality of review.

After “The White Lotus,” Lorazepam Lives On in Memes and Merch (Gift Article) “The White Lotus” Season 3 may be ending, but the medication that has become synonymous with it has found a new life in memes and merchandise.

Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2025/04/06/s... The 6 April article is a tired, clickbait driven approach focusing on adverse effects. See Am J of Psych 03,2024 in users for >3 y, no indication of dose escalation.

People are prone to make up reasons for the term "dissociative." It was originally coined by Ed Domino's wife.

Tufekci starts her second paragraph stating that people who brought up a lab leak were labeled “kooks” or “cranks”.

Let me tell you, when I brought up that possibility, neither the head of the NIH, NIAID, or Wellcome thought I was a crank.

Instead, they encouraged me to investigate further.

You may

Sandhill cranes retuning to Platte river for the night.

For all my birder follows with impressive telephoto lenses, here are iPhone photos of thousands (current total census=585,000) of Sandhill cranes returning to the Platte River for the night.

Exactly, the next question should be "tell me how that algorithm works."

Given the retirement of Francis Collins it is noteworthy that as he described NIH staff, he too was an "individual of extraordinary intellect and integrity, selfless and hard-working, generous and compassionate." This characterization unfortunately will not apply to Jay Bhattacharya.

He will never reach the level of scientific accomplishment and impact of Fauci and Collins.

Controversial health economist is Trump’s pick to head NIH Researchers have mixed views on nomination of Jay Bhattacharya to head biomedical research agency

Grossly unqualified. Accomplishments include senior author on spurious seroprevalence study underestimating COVID-19 infection fatality rate, and advocating policy of intentional mass infection to achieve herd immunity to the virus prior to vaccine introduction.
www.science.org/content/arti...

To Haught’s incisive description add inability to understand developmental biology.

Rather than a shifting voting preference of demographics as hyped by media, the main issue of the election seems to be folks that chose not to vote. Trump's popular vote was similar to 2020 (75.1 vs 74.2 million) while Harris tallied almost 10 million less than 2020 Biden (71.8 vs 81.3 million).

Regarding Imane Khalif, her critics don’t understand biology or human development. For example Swyer’s syndrome demonstrates that genotype does not guarantee phenotype. There are many other examples of such developmental disorders.

For @edyong209.bsky.social #birds and others. An example of urban Midwestern (Omaha) birding. This was pre-tornadoes and the lad hasn't been back yet.

www.nytimes.com/2024/03/22/o... Agree 100%!!!