Stellar lineup at Barrels this year... please register soon!!

See 👇for details

Looking forward to hearing about new traveling wave work next week from @kjayant.bsky.social

Sensory responses of visual cortical neurons are not prediction errors Predictive coding is theorized to be a ubiquitous cortical process to explain sensory responses. It asserts that the brain continuously predicts sensory information and imposes those predictions on lo...

1/3) This may be a very important paper, it suggests that there are no prediction error encoding neurons in sensory areas of cortex:

www.biorxiv.org/content/10.1...

I personally am a big fan of the idea that cortical regions (allo and neo) are doing sequence prediction.

But...

🧠📈 🧪

Bilateral integration in somatosensory cortex is controlled by behavioral relevance - Nature Neuroscience How sensory signals from both sides of the body are integrated into a single percept is not well understood. Park et al. show that callosal signaling supports the integration of bilateral tactile stim...

I'm really proud of my two graduate students, Hyein and Hayagreev, for getting this challenging and exciting project across the finish line. We reveal the state-dependent logic that underlies callosal signaling between the somatosensory cortices. www.nature.com/articles/s41...

Happy to have contributed a chapter to this book and excellent resource!

(Plz repost)

I’ve been receiving some good news lately and will be hiring at all levels to expand the lab. Please get in contact if you are interested in reinforcement learning, neural plasticity, neural circuit dynamics, and/or hearing rehabilitation.

pierre.apostolides @ umich .edu

Tyvm

Wonderful news! Congrats to them and you 👏

Across the neural hierarchy, sensory maps are thought to transition from a faithful representation of receptor space to a map weighted by learned associations. Where does this transformation occur? In our latest paper, we explore a value-based spatial transformation between cortex and midbrain.

Hi friends, If you haven't seen it already, I was part of a mess this week — about science in the United States, and about NIH research aimed at understanding things like Alzheimer's, schizophrenia, autism, and depression.

🧪 Thread with some details. 🧠📈 🧠🤖
1/10

Research Technician I (Emotional Brain Institute) (210-2025-06) - Orangeburg, NY JOB DESCRIPTION: The Emotional Brain Institute (EBI) is a multidisciplinary institute aimed at addressing fundamental questions in neuroscience and neuropsychiatry. We seek to hire a research technici...

I'm hiring a full-time research technician to work in my lab at Nathan Kline. Benefits included! Some lab experience preferred... experience with mouse surgeries a huge plus. If you live in NYC, there are two daily shuttles that take ≈20 min from upper manhattan. nki.applicantpro.com/jobs/3663631

Slow cortical dynamics generate context processing and novelty detection The cortex amplifies responses to novel stimuli while suppressing redundant ones. Novelty detection is necessary to efficiently process sensory inform…

Our new paper is out in Neuron! We characterize auditory prediction errors across primary and secondary regions, to simple and complex stimuli. Deviance detection (and context) are distinct from basic adaptation -- even in a simple oddball paradigm. 1/2

www.sciencedirect.com/science/arti...

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.

grants.nih.gov/grants/guide...

absolutely!

Thanks for the post, I hope you enjoy the read! I would love to hear feedback on this aspect

The first preprint of my postdoc with @dudman.bsky.social is now online! Here we wanted to understand the algorithms mice use when learning to forage in large environments with many potential resources. www.biorxiv.org/content/10.1...

The Caltech and JPL Disaster Relief Fund

Hundreds of Caltech and Caltech/Nasa Jet Propulsion Lab scientists, professors, and students have lost their homes in the LA fires.

The Disaster Relief Fund is organized to help. Please share.
giving.caltech.edu/areas-to-sup...

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Really proud to see my postdoc work out!!

We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging

www.science.org/doi/10.1126/...

Touch-evoked traveling waves establish a translaminar spacetime code Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.

Fresh off the press, our paper linking #TravelingWaves #Cortex #Dendrites #inhibition is online
@ScienceAdvances www.science.org/doi/10.1126/...
A brilliant effort led by
@dgonzales1990.bsky.social and others. A big thanks to collaborators Lyle Muller and Scott Pluta
Thank you, NIH and AFOSR!

Site-specific seeding of Lewy pathology induces distinct pre-motor cellular and dendritic vulnerabilities in the cortex Nature Communications - Misfolded α-synuclein propagates trans-neuronally through anatomically interconnected networks, but how this propagation impacts cellular and circuit activity is...

First Post on Blue Sky promoting science from the group!
Delighted for the first Neurodegeneration paper from my lab. Led by Hammad Khan and wonderful collaborators, we reveal cortical circuit biomarkers delineating the gradual progression of Lewy pathology across synucleinopathies rdcu.be/d5f3w