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Posts by Journal of Clinical Epidemiology

Very excited to have this paper published!

3 weeks ago 4 2 0 0
AI-Enabled Exploitation of Open Science: A Response to Zil-E-Ali on Safeguarding Data Research Integrity We thank Zil-E-Ali for engaging with our findings on the exploitation of open data resources and harms to the evidence base, and for raising the question of equity and the underlying goals of Open Sci...

AI-Enabled Exploitation of Open Science: A Response to Zil-E-Ali on Safeguarding Data Research Integrity - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 2 2 0 0
Preliminary appraisal of machine learning based prediction models A significant portion of healthcare research is devoted to the development of prediction models, yet the integration of these models into routine clinical care remains limited. Persistent barriers, su...

Preliminary appraisal of machine learning based prediction models - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
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When systematic review meets realist review: proposing a hybrid review design to understand complex intervention effectiveness and mechanisms Systematic reviews (SRs) and realist reviews (RRs) are increasingly conducted in a coordinated manner with intersecting methodological processes, forming what we term hybrid review designs. However, l...

When systematic review meets realist review: proposing a hybrid review design to understand complex intervention effectiveness and mechanisms - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 6 1 0 1
Beyond One Direction: Revisiting the Fragility Index The Fragility Index (FI) has become a valuable complement to traditional statistical measures, offering an intuitive sense of the strength of clinical evidence. We encourage its continued use while pr...

Beyond One Direction: Revisiting the Fragility Index - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 2 1 0 0
How to evaluate probabilistic prediction models: Key metrics Probabilistic clinical prediction models play a critical role by informing healthcare professionals both in diagnosis and prognosis. To assess the qualities of a probabilistic prediction model, perfor...

How to evaluate probabilistic prediction models: Key metrics - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
Learning from every patient: the ‘outpatient innovation clinic’ To keep pace with rapid medical innovation, healthcare must be organized to enable systematic learning from every patient. The ‘outpatient innovation clinic’ was established to support this goal. This...

Learning from every patient: the ‘outpatient innovation clinic’ - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
Safeguarding the Open Data Ecosystem and Regulating the Misuse of Public Health Datasets in an Era of Rapidly Scaled Research Production The exploitation of open-access health datasets by paper mills and AI-assisted workflows represents a growing threat to the integrity of clinical evidence. Spick et al. provide a valuable scientometri...

Safeguarding the Open Data Ecosystem and Regulating the Misuse of Public Health Datasets in an Era of Rapidly Scaled Research Production - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
Evaluating the accuracy of screening titles and abstracts for progressing to full text screening by one versus two independent reviewers: Part 1 of a meta-research study of rapid review methodological... To determine the accuracy for progressing records to full text screening using one versus two reviewers to screen title and abstracts in three reviews of the effectiveness of interventions for chronic...

Evaluating the accuracy of screening titles and abstracts for progressing to full text screening by one versus two independent reviewers: Part 1 of a meta-research study of rapid review methodological trade-offs - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
Association between potentially inappropriate prescribing and adverse patient outcomes using codified STOPP-START and Beers criteria in large, routinely collected population health datasets: a retrosp... To assess the association between potentially inappropriate prescribing and adverse patient outcomes (mortality, hospitalization, and emergency department visits) in a large, population-based cohort o...

Association between potentially inappropriate prescribing and adverse patient outcomes using codified STOPP-START and Beers criteria in large, routinely collected population health datasets: a retrospective cohort study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 3 1 0 0
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Limited consensus in expert opinions on studies evaluating the design, conduct, analysis, or reporting of health research: a survey study Methodological studies critically evaluate how health research is designed, conducted, analyzed, and reported. Despite their growing importance, currently, there is no reporting tailored to this type ...

Limited consensus in expert opinions on studies evaluating the design, conduct, analysis, or reporting of health research: a survey study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

3 weeks ago 4 3 0 0
Editors' choice April 2026 If the history of evidence-informed health-care research tells us anything, it is that interventions that are launched with the most fanfare and media hype should occasion sensible people to start cou...

Editors' choice April 2026 - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

4 weeks ago 4 1 0 1
Guidance to including grey literature in systematic reviews-recommendations from an epidemiological study Grey literature are materials produced outside traditional academic or commercial publishing such as theses, conference proceedings, technical reports, and government documents. Grey literature is oft...

Guidance to including grey literature in systematic reviews-recommendations from an epidemiological study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 6 2 0 0
Semi-Automated Screening in Living Guideline Maintenance: A Simulation Study of 90 Machine Learning Prioritised Screening System Configurations (Protocol) Living guidelines are an emerging approach to ensuring guideline recommendations remain relevant to the needs of stakeholders and frontline clinical care. However, development and maintenance remain m...

Semi-Automated Screening in Living Guideline Maintenance: A Simulation Study of 90 Machine Learning Prioritised Screening System Configurations (Protocol) - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 4 1 0 0
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Standardizing physical function across assessment types: Three versions of the Physical Performance Test were linked to the PROMIS Physical Function metric in diverse populations Physical function (PF) is a relevant outcome in ageing and clinical populations, commonly assessed through patient-reported outcome (PRO) or performance-based outcome (PerfO) assessments. While variou...

Standardizing physical function across assessment types: Three versions of the Physical Performance Test were linked to the PROMIS Physical Function metric in diverse populations - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 2 0 0
Broadening the Scope of Meta-Research: From Methodologists to Stakeholders

Broadening the Scope of Meta-Research: From Methodologists to Stakeholders - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 3 1 0 0
Concordance analysis of the Short-Form of the PROBAST as a Screening Tool: Two-Step Risk of Bias Assessment showing only Underestimation of Risk of Bias Prediction models used in clinical practice often suffer from high risk of bias (ROB), which affects their reliability. The Prediction model Risk Of Bias ASsessment Tool (PROBAST) assesses ROB, but is...

Concordance analysis of the Short-Form of the PROBAST as a Screening Tool: Two-Step Risk of Bias Assessment showing only Underestimation of Risk of Bias - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 1 0 0
ClinicalTrials.gov

Reporting of sodium-glucose cotransporter 2 (SGLT2) inhibitor trial safety: an observational analysis of ClinicalTrials.gov registrations and journal publications - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 5 1 3 0
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An exploratory descriptive survey on the use of GRADE and CINeMA: time-consuming, process transparency and subjectivity versus high-speed, practical challenges and poor understanding To explore assessors’ experience regarding the use of two approaches that evaluate the certainty of evidence from Network Meta-Analysis (NMA): Grading of Recommendations Assessment, Development and Ev...

An exploratory descriptive survey on the use of GRADE and CINeMA: time-consuming, process transparency and subjectivity versus high-speed, practical challenges and poor understanding - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 4 2 0 0
Developing a tool for supporting health-system guidance implementation Paper 2: A developmental and formative evaluation study To develop a practical tool to support the implementation of health-system guidance (HSG).

Developing a tool for supporting health-system guidance implementation Paper 2: A developmental and formative evaluation study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 3 1 0 0
Developing a tool for supporting health-system guidance implementation Paper 1: A modified Delphi method to develop the tool components To identify consensus-based components for a tool to support health-system guidance (HSG) implementation.

Developing a tool for supporting health-system guidance implementation Paper 1: A modified Delphi method to develop the tool components - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 4 2 0 0
Psychometric properties of instruments for assessing the methodological quality and risk of bias in non-randomized studies of interventions: a systematic review and meta-analysis in accordance with th... Non-randomized studies of interventions provide valuable evidence in health sciences but are prone to biases that affect validity. Multiple instruments have been developed for critical appraisal, alth...

Psychometric properties of instruments for assessing the methodological quality and risk of bias in non-randomized studies of interventions: a systematic review and meta-analysis in accordance with the COSMIN guideline - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 3 1 0 0
Methods for living guidelines: Learnings from developing and disseminating implementable living guidelines in the Australian context Living clinical guidelines provide decision-makers with up-to-date, reliable guidance to inform clinical and policy decisions. As the production of living guidelines increases internationally, it is i...

Methods for living guidelines: Learnings from developing and disseminating implementable living guidelines in the Australian context - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 2 0 0
Criteria to Prioritize Clinical Practice Guideline Recommendations for Patient Decision Aid Development: Results from a Modified Delphi Consensus Study Linking patient decision aids (PtDAs) to clinical practice guidelines (CPGs) can improve the integration of patient preferences into healthcare decisions. However, due to the extensive number of recom...

Criteria to Prioritize Clinical Practice Guideline Recommendations for Patient Decision Aid Development: Results from a Modified Delphi Consensus Study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 1 0 0
Large language models show promising performance for some systematic review tasks but call for cautious implementation : a systematic review With the exponential growth of biomedical literature, the challenge of conducting systematic reviews is becoming increasingly burdensome. We aimed to evaluate the performance of LLMs in the automation...

Large language models show promising performance for some systematic review tasks but call for cautious implementation : a systematic review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 2 0 0
A systematic review to identify how children and young people were included in the development of pediatric core outcome sets Core outcome sets (COS) are an agreed upon set of outcomes that should be evaluated in a clinical trial, allowing data from similar areas of healthcare to be compared and pooled in meta-analyses, info...

A systematic review to identify how children and young people were included in the development of pediatric core outcome sets - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 1 0 0
Trustworthiness and Transparency Features Were Less Frequent in Randomized Trials Presenting Large Effects for Continuous Outcomes in Abstracts Large effect sizes (ESs), especially when prominently presented in trial abstracts, draw large attention, but it is important to understand whether they are trustworthy. We aimed to assess indicators ...

Trustworthiness and Transparency Features Were Less Frequent in Randomized Trials Presenting Large Effects for Continuous Outcomes in Abstracts - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 3 1 0 0
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1 month ago 0 0 0 0
SPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study Genetic mutations often result in antimicrobial resistance. Early identification of emerging resistance due to genetic mutations often relies on multiple co-existing pathways of indirect evidence. The...

SPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 1 1 0
The importance and need for SWAT coordination Studies Within A Trial (SWATs) provide evidence for trial process decisions by evaluating alternative trial processes or exploring why processes are undertaken. SWATs can be undertaken as: ‘Individual...

The importance and need for SWAT coordination - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

1 month ago 2 1 0 0