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Paracetamol use in pregnancy

We are aware of recent claims from the US questioning the safety of paracetamol use in pregnancy. These claims are not based on new evidence. Our full statement is here: tinyurl.com/5yye2npu

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

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Can we trust research?

The ENTRUST-PE framework conceptualises the construct ‘trustworthiness’ of research to be supported by 7 core values.

From: Editorial commitment to trust and integrity in science: implications for pain and anaesthesiology research

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Utah Republicans push to let patients supply their own blood as vaccine concerns linger Health care facilities in Utah would be required to let patients bring their own blood or choose their own donor for medical procedures under legislation gaining momentum in Utah

We continue to see legislative efforts to mandate that blood banks/hospitals allow patients to use directed or autologous blood donations without medical indication. These are driven by vaccine-related fears which lack any scientific grounding. This is problematic for multiple reasons… 1/

Why are patients readmitted after surgery?
• wound complication 11%
• falls or other mechanical injuries 7%
• pneumonia 7%
• ileus or bowel obstruction 6%
• heart failure/pulmonary oedema 5%

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https://doi.org/10.1111/anae.16567

I use it for transfemoral TAVI. I give 0.625mg droperidol, then load 0.4mcg/kg over 20 mins and run at 0.2-0.4mcg/kg/h to effect. These patients are elderly with chronotropic incompetence, so bradycardia is not pronounced. We also have a pacing wire as part of procedure which minimises risk.

The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial In the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, the use of intravenous iron did not reduce the need for blood transfu...

The data for most of this response comes from this paper. Fundamentally, not every form of anaemia will respond to iron alone. Anaemia is a symptom of an underlying condition. To treat successfully, treat the cause.

associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/full/10....

Depends on the iron studies! For ferritin < 30, IV iron can cause fairly rapid increases in Hb within 2 weeks. For ferritin < 100 + TSAT < 20%, it likely takes > 4 weeks. Oral iron generally takes > 3 months as the amount of iron transported across the gut daily is fairly small.