Last Night, John Oliver did a show on the NIH and indirect Costs. Watch the link below! A must watch🧪

On April 24, we celebrated the 50th anniversary of the Department of Genetics at Washington University. We heard about its history from Bob Waterston and Eric Green and how the former trainees are moving science forward.
NHGRI has great resources for those interested in the history of Genomics.

That’s a wrap! We hope you enjoyed our 50th Anniversary Celebration and Symposium as much as we did! Thank you to all the speakers, students, faculty and staff who attended the event. Here’s to more amazing years at the Department of Genetics at WashU Medicine!

My linocut in green ink on grey washi paper with fibres and tiny bark inclusions. A young Charles Darwin in a suit crouches on the back of a tortoise.

Happy birthday to Charles Darwin (1809-1882)! Today is Darwin Day to celebrate his birthday, science and evolution. 🐡🧪

“The inhabitants believe that these animals are absolutely deaf; certainly they do not overhear a person walking closely behind them. I was always amused, when overtaking one of 🧵

Aberrant homeodomain–DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

It was a lot of fun getting to contribute to this paper, probably my last paper on transcription factors. The most surprising result is that the E80A mutation has only a minor effect on specificity but a large decrease in cooperativity and is a dominant mutant. 🧪
genome.cshlp.org/content/earl...

Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia CCDC39 and CCDC40 variants interrupt the motile cilia assembly program, disrupt cilia architecture, and alter motility-independent cell functions.

Thanks to the three reviewers for their thoughts and suggestions www.science.org/doi/10.1126/...

Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

I'm happy to report this paper is now available.
The most interesting thing, to me, is that the E80A mutation has only a minor effect on specificity, but a large effect on cooperativity, and is a dominant mutant.

genome.cshlp.org/content/earl...