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Posts by Simone Minnie

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Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential Persistent antigen stimulation promotes differentiation of exhausted CD8+ T (TEX) cells. TEX cells are distinct from circulating memory T (TCIRCM) cells but share many features with tissue-resident me...

What's the difference between Trm and exhausted CD8 T cells? Simone Park's new work dissects this important question. These cell types are often confused, but are ontologically and mechanistically distinct with implications for immunotherapy responses. www.biorxiv.org/content/10.1...

8 months ago 32 6 0 0

Contact me directly with your CV if you’re interested. Full disclosure that I may not be able to respond to all messages if this goes anything like my last job ad!

9 months ago 0 0 0 0

Now that the lab has stuff in it, I’m looking for a postdoc.

Must have:
- Mouse experience (several years ideally)
- Cell culture experience
- An interest in T cells
- Team player

Bonus points for:
- any flow experience
- any scRNAseq exp (wet or dry)
- CAR T manufacturing

9 months ago 0 0 1 0

Seeing my colleagues succeed brings me so much joy. Can’t wait for the ‘proud PI’ moments to come from my lab. I’ve already asked my trainees how they like to receive recognition and they are both the quiet email types. This will be a challenge…gotta rein it in!

10 months ago 0 0 0 0
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Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation PURPOSEAllogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for advanced hematologic malignancies. HSCT using human leukocyte antigen (HLA)-mismatched donors is historical...

Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation | Journal of Clinical Oncology ascopubs.org/doi/10.1200/...

10 months ago 3 1 0 0

The best advice I received about hiring was always hire people smarter than yourself. I’ve taken that very seriously, plus added my own criteria “vibes”, and I am so excited for the new Minnie Lab team members to start soon!!

10 months ago 1 0 0 0

Reminder:

Not everything thought needs to be said

Not everything said needs to be written

Not everything written needs to go on social media

10 months ago 28 2 0 1
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We set out to quantify U.S. academic contributions to medicines. The results stunned even us From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.

The astounding contribution of US academic science to new medicines

www.statnews.com/2025/06/06/u...

10 months ago 93 53 3 1
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An Il12 mRNA-LNP adjuvant enhances mRNA vaccine–induced CD8 T cell responses IL-12 is dispensable for CD8 T cell responses to mRNA vaccination, but an Il12 mRNA-LNP enhances CD8 T cell memory and protection.

How adding mRNA to code for interleukin-12 markedly increased T cell immune response which could be used for vaccines vs infectious diseases and cancer @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

10 months ago 366 85 5 5
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Minnie Lab - Junior, Assistant, or Associate Specialist University of California, San Francisco is hiring. Apply now!

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested!

aprecruit.ucsf.edu/JPF05438

1 year ago 2 1 0 0

I also started the hiring process months early - I haven’t even started yet! And it was exceptionally lucky under these circumstances that I did, but I do recommend all new faculty do it anyways!

1 year ago 0 0 0 0

Hiring freeze at the same time as starting a lab will keep things interesting. Got one hire through the door before it happened at least. This tech really wanted some hands-on training and boy are they going to get it 😂

1 year ago 0 0 1 0
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Fred Hutch at #Tandem25: Catch presentations from Drs.
Julie Boiko, Rachel Salit, @simone-minnie.bsky.social and Marie Bleakley on cGVHD biology, basic science of GVL and post-HCT immune microenvironment, T cell responses to minor histocompatibility antigens & more 👉 bit.ly/3EAM24L

1 year ago 10 2 0 0
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Minnie Lab - Junior, Assistant, or Associate Specialist University of California, San Francisco is hiring. Apply now!

If you are interested in translational science but also love digging into a good immunology mechanism, please contact me! I'm hiring at all levels. There is a research technician job ad out already (aprecruit.ucsf.edu/JPF05438) but I'll be looking for postdocs too!

1 year ago 4 0 0 2

I am beyond excited to be starting my lab at UCSF in May 2025. I'll be joining the Hematology/Oncology Division and working with the Myeloma Program (lead by @ajaichari.bsky.social) to advance immunotherapies and cellular therapies for myeloma!

1 year ago 9 1 6 2
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Happy New Year! 2025 is going to be a big one!!

1 year ago 2 0 0 0

Very exciting news! My COI is that my dad owns a bunch of shares on the Australian side. Bought them years ago and I was a naysayer. So happy to be wrong!!

1 year ago 1 0 0 0

Hematologists please follow Ajai Chari, the very talented leader of the @ucsfcancer.bsky.social #myeloma program. #hematology

bsky.app/profile/ajai...

1 year ago 4 2 0 0

What a win for myeloma research at Fred Hutch!!! Welcome Madhav!

1 year ago 2 0 0 0
Paper: Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment

Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...

1 year ago 12 4 1 0
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This might just end up being a PNW nature shots account for the next couple of days 😅 It’s so beautiful here!

1 year ago 0 0 0 0
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Break from scientific programming to say that the PNW is truly one of the most beautiful places I’ve ever lived!

1 year ago 1 0 0 0

This was one of the most useful courses I’ve ever done. Highly recommend. Don’t walk, run!!!

1 year ago 1 1 0 0
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Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
www.nature.com/articles/s41...

1 year ago 23 5 0 3
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The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer - Nature Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8+ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against...

Presenting this paper at journal club tomorrow and I’m actually so excited to share it with the lab. I’ve said it at the other place and I’ll say it here, it’s just a beautiful paper!!!

www.nature.com/articles/s41...

1 year ago 3 0 0 0
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Idk, I’ve been in restaurants where groups of adults can’t use their inside voice and we can’t have a conversation over the obnoxious laughing and yelling. I don’t take my toddler to restaurants because I personally don’t want to have a bad time, but could we ban those adults too?

1 year ago 0 0 0 0

If you're interested in Stem cell transplant and/or Cellular Therapy this is the list #bmtsm #CARTcells #leusm #mmsm #lymsm #MedSky #TcellRx go.bsky.app/7xxh8WW

1 year ago 42 26 1 1
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Degradation of IKZF1 prevents epigenetic progression of T cell exhaustion in an antigen-specific assay Tay et al. demonstrate an antigen-specific assay producing exhausted T cells that reflect those found in human tumors. They identify IKZF1 (IKAROS) as a driver of exhaustion progression and validate t...

Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay

www.cell.com/cell-reports...

1 year ago 44 11 2 0

Follow me for more mentoring thoughts that I’m literally stealing from parenting books 😂. Apparently just being an empathetic adult goes a long way to fostering collaborative relationships both at home and at work.

1 year ago 0 0 1 0

Finally, it doesn’t take away anything from anyone to acknowledge feelings/perceptions before offering advice. Sometimes people don’t want advice, just a “yeah that sucks.” Anyways, that’s my yet to be tested 2 cents so take it with a grain of salt.

1 year ago 0 0 1 0