Autoimmune diseases affect nearly 50 million Americans & 4 of 5 are women
doi.org/10.1172/JCI1...
In this Research Letter, Howard Y. Chang @howardychang.bsky.social & team show autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases
PPARα–NF-κB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6
In obesity, the heart can thicken, preventing it from functioning properly
Junichi Sadoshima & team find direct stimulation of IL-6 transcription by PPARα in cardiomyocytes plays an important role in mediating the initial development of obesity cardiomyopathy: doi.org/10.1172/JCI1...
In prostate cancer, treatment resistance and disease progression can be promoted by androgen receptor splice variants
Here, Johann de Bono, Luke Gaughan & team identify the protein TRA2B as being key for the synthesis of AR-Vs: doi.org/10.1172/JCI1...
FOXP1 syndrome leads to specific sleep problems
doi.org/10.1172/JCI1...
Mireia Coll-Tané, Annette Schenck & team identify FOXP transcription factors as regulators of sleep maintenance across species & uncover developmental dysregulation of neuropeptide signaling as a causal mechanism
From earlier this week: Do cells of different lineages age differently?
doi.org/10.1172/JCI1...
Sundeep Khosla & team compare the senescence phenotype of mesenchymal versus immune cells from murine bone and bone marrow, revealing important differences between them.
A sweet result in sepsis
doi.org/10.1172/JCI2...
ASCI member Eric P. Schmidt @schmidtlab.bsky.social & team find plasma concentrations chondroitin sulfate predicted the response to a randomized liberal or restrictive intravenous fluid resuscitation strategy in patients with sepsis and hypotension.
A sweet result in sepsis
doi.org/10.1172/JCI2...
Eric P. Schmidt @schmidtlab.bsky.social & team find plasma concentrations chondroitin sulfate predicted the response to a randomized liberal or restrictive intravenous fluid resuscitation strategy in patients with sepsis and hypotension
Retinal pigment epithelium pseudopods reach across the divide to maintain photoreceptor performance and save vision: doi.org/10.1172/JCI2...
Akrit Sodhi provides an Editor’s Note on Lewis et al.: doi.org/10.1172/JCI1...
Deconstructing senescence phenotypes in cells of the bone and bone marrow: doi.org/10.1172/JCI2...
Lorenz C Hofbauer & Martina Rauner comment on Doolittle et al.: doi.org/10.1172/JCI1...
Following up on our March Research Letter: Detection of clonal hematopoiesis of indeterminate potential via genome or exome sequencing underestimates disease associations by by Alexander G. Bick, @yashpershad.bsky.social et al. & team: youtu.be/s9CVn_gIvj4
Post: www.jci.org/posts/727
A tuberculosis cure is accelerated by immunotherapy targeting: youtu.be/1qtO0ybJPHE
Post: www.jci.org/posts/728
Article: www.jci.org/articles/vie...
Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study: doi.org/10.1172/JCI2...
Sarah K. Royse & Rajesh Narendran comment on Zakiniaeiz et al.: doi.org/10.1172/JCI1...
What’s happening 3 months before HIV-1 infection?
doi.org/10.1172/JCI1...
Mwikali Kioko & team report people at high risk for HIV-1 infection in an African cohort show differences in immune responses before infection, which may influence HIV-1 acquisition.
Behind the scenes with the first author, Sam Jordan...making science happen...
Cardiac radiotherapy–induced epigenetic memory underlies electrophysiologic and metabolic reprogramming
The mechanism undlerlying stereotactic arrhythmia radiotherapy (STAR) is incompletely understood
doi.org/10.1172/JCI1...
Here, Stacey L. Rentschler & team find radiation mediates durable changes to the cardiomyocyte transcriptome & epigenome with electrophysiologic reprogramming
Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes
Do cells of different lineages age differently?
doi.org/10.1172/JCI1...
Sundeep Khosla & team compare the senescence phenotype of mesenchymal versus immune cells from murine bone and bone marrow, revealing important differences between them.
Neuroblastoma is a pediatric cancer with high mortality in which FGFR1 mutations have been described
Werr et al. now introduce a new mouse model, finding FGFR1N546K as a strong oncogenic driver & suggesting FGFR inhibitors provide a strategy for high-risk NB: doi.org/10.1172/JCI1...
Scientific Paper published in The Journal of Clinical Investigation, titled: Androgen receptor splice variant 7 expression levels distinguish AR-mutated from nonmutated metastatic castration-resistant prostate cancers. Written by Paschalis et al.
Could AR mutation status serve as a predictive biomarker for AR‑targeted therapies in #ProstateCancer?
A team led by Prof de Bono at @icr.ac.uk, supported by our Movember London Centre of Excellence, share findings in @jci.org.
Grab a ☕ & read: doi.org/10.1172/JCI1...
Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models
Behind the scenes: From flow cytometry to the microscope to the bench, first author Styliani Karanika measures vaccine-induced T cell responses, inspects Luminex cytokine assays, and prepares immune assays targeting drug-tolerant Mycobacterium tuberculosis persisters.
Detailing the effects of a new therapeutic tuberculosis vaccine!
Styliani Karanika & team report on an intranasal DNA vaccine that accelerates TB cure and achieves better outcomes than standard or drug-resistant regimens alone in preclinical models: doi.org/10.1172/JCI1...
And for additional insight - @decmccole.bsky.social wrote a fantastic commentary!
www.jci.org/articles/vie...
TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics
A patient with severe colonic infantile onset inflammatory bowel disease reveals a role for TNFSF13 in colonic epithelial cells
@khamiltonphd.bsky.social & team discover epithelial TNFSF13 regulates colonic epithelial growth and epithelial-B cell interactions: doi.org/10.1172/JCI1...
Presenting the first in-human evidence of lower synaptic density in people with alcohol use disorder: doi.org/10.1172/JCI1...
Zakiniaeiz et al. find synaptic density deficits are evident in people with alcohol use disorder & those with greater deficits show greater drinking severity
Excited to share that my thesis work is now published in @jci.org
jci.org/articles/view/…
Take a look if you’re curious about:
📍 Regionality in Crohn’s disease - AC vs. TI
🦠 A possible role for pathobionts in Crohn’s disease
🔥 Epithelial mediators of inflammation
Adam9-deficient retinal pigment epithelium pseudopods maintain photoreceptor outer segment renewal despite subretinal space expansion