How do the ancestors of CRISPR-Cas unwind DNA and how can this lead to better genome editing? With our collaboration between @doudna-lab.bsky.social x @jacobsenucla.bsky.social x Zev Bryant's lab x @savagecatsonly.bsky.social we've uncovered the secrets behind TnpB's dynamics!
New preprint 👉Doudna x Bryant x Jacobsen x Savage collaboration!
Work led by @zehanzhou.bsky.social, I. Saffarian-Deemyad, @honglue.bsky.social, T. Weiss
We dissect how stepwise DNA unwinding gates TnpB genome editing, revealing how unwound DNA states enhance cleavage
www.biorxiv.org/content/10.6...
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
Excited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to
@petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
Big congrats to @petrskopintsev.bsky.social and @isabelesain.bsky.social !
First co-led work from the Doudna lab 🤜🤛
We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
Very looking forward to having you in the lab! 💪🏼🧬✨
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
Super cool work by @erinedoherty.bsky.social and @jnoms.bsky.social ! 💪🏼
Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
👩🏻🔬La investigadora española @isabelesain.bsky.social ha sido galardonada por su tesis doctoral contra el #cáncer en el @cruk-mi.bsky.social.
🗣️"El genoma humano es como un libro que tiene muchos capítulos".
🎬 En @aragontv.bsky.social.
www.cartv.es/aragonnotici...
Thank you very much!
So honored to receive the Best Thesis Prize❤️ @cambridgeuni.bsky.social @cruk-ci.bsky.social still feels surreal. Thank you to CRUK, my supervisors for believing in my ideas, and my former lab members, friends and family for always supporting me. So grateful to be part of such an inspiring community!
The Alker lab at the University of Rhode Island is hiring (students, postdocs and lab staff)! We use cutting edge tools in microbiology to investigate marine animal symbioses. Email or DM for further inquiries
🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨
If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊