Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are l...

New work from my team: pubs.acs.org/doi/10.1021/...
We used probes to ID targets of carbapenems in M. abscessus. 17 targets active in both carbon starved and replicating cultures. Includes validation of 9 targets. Part of a special issue ("NTM Pathogens – Biology, Infection, and Drug Discovery).

Infographic showing risks vs benefits of giving measles/MMR vaccine

Today, I was asked by a grandparent about benefits vs risks of vaccines, so she can talk to her kids & grandkids

I shared this superb infographic @peterhotezmdphd.bsky.social, published @plosglobalpublichealth.org

We need such infographics for all vaccines!!

journals.plos.org/globalpublic...

Vaccine invented. Disease plummets. (Repeat)

Over the seven decades since the polio vaccine, we have seen this pattern again and again.

Vaccines have a great track record.

Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

@hhmi-science.bsky.social's
#FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits

Stable, sustained support can transform your career:

Senior Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA

It’s really that simple

No child needs to suffer from measles

A series of spontaneously blinking dyes for super-resolution microscopy - Nature Methods A series of spontaneously blinking dyes in the far-red range facilitate single-molecule localization microscopy. These dyes vary in their blinking properties and can be matched to the applications and...

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Opinion | Big Tech Owes Scholars. It’s Time to Pay Up. The expert knowledge powering AI came from the academy. Time to pay up.

I don't use AI for my scholarly writing. My papers/reviews/grants/etc. are original text generated by me. Because of this, I am deeply uncomfortable with the theft of written work/ideas from authors and scholars to train large langue models. I agree with is: 👇
www.chronicle.com/article/big-...

I am looking forward to the 2026 PacTB meeting, which starts in less than an hour. @ohsunews.bsky.social is hosting this year, and attendees will come from across the west coast to discuss mycobacterial pathogens. 🧫💉🔬🦠

Your post inspired me to post my dissent to all that is being done to destroy research in the US. Thank you.

I absolutely have a viewpoint. Until recently, the US was a leader in research & NIH was something of which all Americans could be proud. Productive, innovative, life-saving. Trump, RFK Jr., and Bhattacharya are systematically destroying our research capacity. I won't be silent in my dissent.

Shadows at the Edge of Lunar Day - NASA art002e009281 (April 6, 2026) – The Artemis II crew captures a portion of the Moon coming into view along the terminator – the boundary between lunar day and night – where low-angle sunlight casts lon...

Such an amazing moon we have.

www.nasa.gov/image-detail...

That is pretty awful!

You don't get the 2 weeks???

The President's fiscal year 2027 Budget was released today.

Important---Important---Important

The President's Budget is always fundamentally a political document that Congress may or may not (usually not) take very seriously.

www.whitehouse.gov/wp-content/u...

1/9

My most recent PhD candidate, who was amazing (Julia Doh) defended in April 2020. I love working with graduate students, but OHSU's program is small (15-20 students/year for all the faculty). Advice?

The term "sexual purity" makes me want to vomit.

I serve on NIH study sections. I consider it a privilege and a duty. It is hard but rewarding work. Right now it seems like the least I can do to support our colleagues at NIH.

Does College Pay Off? A Comprehensive Return On Investment Analysis - FREOPP While prospective students often ask themselves if college is worth it, this report shows the more important question is when college is worth it.

I place a really high value on a college education. I wish that college was more accessible. Yet, I found this article absolutely fascinating. The ROI varies widely-- I wish that programs/colleges were forced to disclose this information.
freopp.org/whitepapers/...

Spring has arrived in Oregon.

Color chemistry

From Galbraith & Galbraith: “tradewinds” bring soluble proteins to the leading edge – with a nice assortment of microscopy approaches including iPALM www.nature.com/articles/s41...

Thank you so much for holding Bhattacharya responsible for his lies.

We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...

The United States is driving a public health emergency of international concern Matthew Herder and colleagues call for broader mobilisation to avoid the deaths and morbidity in low and middle income countries likely to result from recent US policy changes Announcing the United ...

I wish Trump, Musk, and RFK Jr. could directly observe the suffering & deaths that they are causing. This call to action for WHO is timely because, as stated, "...the US’s recent decisions have greatly amplified the risk of multiple international outbreaks of disease".

www.bmj.com/content/392/...

The vaccine news headlines are frustrating-- they read like there is new information. "Vaccines prevent measles!" "Vaccines save lives!" They should be accompanied by a 1950s voice-over like those jokey documentaries on film strips for kids.

Following @joshuasweitz.bsky.social post and discussions with him and the Vox story, I have estimated R01 success rates for each NIH institute and center with enough awards for this to be meaningful.

A long 🧵...

1/25

How DOGE Gutted the NEH in 22 Days Internal documents show how leadership at the National Endowment for the Humanities handed over the grant termination process to DOGE and ChatGPT.

Big surprise, the DOGE wrecking ball made a lot of bad decisions, with no expertise, with no clear thought, and their actions were most likely illegal. I co-blame Musk and Trump for this one, but Michael McDonald's complicity should cost him his job.
www.insidehighered.com/news/faculty...

Sabotaging the NSF fellowship is a blunder Over the last year, the Trump administration has sent one discouraging message after another to young people aspiring to a scientific career in the United States. The corrosive rhetoric that mocks sci...

There is no logic behind cutting NSF fellowships. None.

Sabotaging the NSF fellowship is a blunder | Science www.science.org/doi/10.1126/...

Cracked, but still there: the glass ceiling persists for senior women in science To mark International Women’s Day on 8 March, Mangala Srinivas reminds junior colleagues that career success won’t protect you from gender-based bias.

Cracked, but still there: the glass ceiling persists for senior women in science www.nature.com/articles/d41...

It is depressing to know that I have been reading articles like this for most of my career and that I will likely keep reading them for the next 20 years. Yes, gender bias persists.

I was using @chimerax.ucsf.edu just now and three of my enzymes look like the cutest lil' sea horses. Happy weekend!