New Review. Journal of Endocrinology logo. Clocks on steroids: how glucocorticoid receptors tell cells the time. By Anna Edmondson et al. Figure 3.Transcriptional and non-transcriptional interactions between the GR and the circadian clock. Transcriptional interactions: i) GR-mediated transcriptional activation of PER1 and PER2 leading to an increase in PER1 and PER2 abundance (17, 26, 27, 41, 42, 43, 75). ii) Direct binding of the GR to CLOCK and BMAL1, which themselves bind to E-boxes upstream of NR1D1. Through tethering, the GR represses NR1D1, resulting in a decrease in REV-ERBa abundance (45, 46). iii) In a rhythmic fashion, CRY binds to the GR and represses the GR’s transcriptional activation activities (54). iv) CLOCK/BMAL1 acetylates the GR’s hinge region to suppress its transcriptional activities (32)...Journal of Endocrinology 269, 1; 10.1530/JOE-25-0340 Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

⏰ Glucocorticoids synchronise cellular circadian rhythms via canonical and rapid non‑canonical GR signalling, but the exact mechanism remains unclear. This review outlines current knowledge, key gaps, and how disrupted GC rhythms contribute to circadian‑linked disease.

doi.org/10.1530/JOE-25-0340

Journal of Endocrinology logo. New Research. TFF3 in Renal Pathobiology: A Novel Lipotoxicity Regulator in Male Mice with Diabetic Kidney Disease. By Jinyuan Zhang et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new study by Jinyuan Zhang et al. examines how TFF3 regulates lipotoxicity in male DKD mouse models. By investigating its effects on the AMPK/ACC & SCAP/SREBP signalling pathways, the study sheds light on the molecular mechanisms linking TFF3 to DKD progression.

🔗 doi.org/10.1530/JOE-25-0303

Journal of Endocrinology logo. New Research. Tmem119 is involved in the bone repair enhanced by parathyroid hormone in female mice. By Ayaka Yamada et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Tmem119 has been shown to participate in the bone anabolic effects of PTH through the stimulation of osteoblastic bone formation in mice.

A new study investigates Tmem119's role in PTH-enhanced bone repair after a femoral bone defect using Tmem119-deficient mice.

🔗 doi.org/10.1530/JOE-25-0375

Journal of Endocrinology logo. New Research. miR-200b-3p inhibits adipose browning by targeting Prdm16. By Lang Qin et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

miR-200b-3p is linked to obesity, but understanding of its role in the pathogenesis of obesity remains limited.

New research by Lang Qin et al. suggests that miR-200b-3p regulates adipocyte browning by targeting Prdm16 & could serve as a therapeutic target.

🔗 doi.org/10.1530/JOE-25-0131

Journal of Endocrinology logo. New Research. Insulinoma with postprandial hypoglycemia and characteristic expression of GLUT2/GCK/GLP-1R. By Shinichiro Toyoda et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

🔎 A new study by Shinichiro Toyoda et al. examines how clinical hypoglycemia phenotypes may relate to the immunohistochemical expression of glucose transporters (GLUTs), glucokinase (GCK), and the glucagon‑like peptide‑1 receptor (GLP-1R) in insulinoma cells.

🔗 doi.org/10.1530/JOE-25-0134

Journal of Endocrinology logo. New Research. Congenital vs adult-onset estrogen deficiency in female mice: physiological effects and implications for therapy. By Ahmed K Aladhami et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

New study compares two major mouse models of estrogen loss - AROM KO (congenital) and OVX (adult‑onset). It highlights shared & distinct E2‑deficient traits, helping researchers choose the right model & offering a rich dataset for studying the effects of estrogen decline.

📄 doi.org/10.1530/JOE-...

Check out the first paper I contributed to!

Journal of Endocrinology logo. New Research. The thyroid hormone metabolite Triac stimulates bone mineralisation in larval zebrafish. By Quinte F Geessinck et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Triac is a thyroid hormone metabolite, with thyromimetic properties, present in sewage treatment plant effluents.

New findings by Quinte F Geessinck raise an important question, could Triac act as an environmental endocrine disruptor?

📖 Read the research: doi.org/10.1530/JOE-25-0480

Journal of Endocrinology logo. New Research. Iron homeostasis links the association between alcohol consumption and liver steatosis/fibrosis: a multi-cohort analysis. By Xin Zhang et al. Graphical Abstract from https://doi.org/10.1530/JOE-25-0293 Published by Bioscientifica logo. 80 Years 1964-2026 Society for Endocrinology logo.

A new multi‑cohort analysis investigates how disrupted iron homeostasis & alterations in iron metabolism may link alcohol intake to hepatic injury. The study provides novel evidence that pure alcohol intake is significantly associated with liver steatosis and fibrosis.

🔗 doi.org/10.1530/JOE-25-0293

Journal of Endocrinology logo. New Research. Progressive impact of polycystic ovary syndrome on hormonal alterations, bone microarchitecture, and mechanical properties By Sarita Pandey et al. Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

A new study focuses on how the duration of PCOS influences hormonal profiles, bone metabolism, and bone’s microstructural and mechanical properties in the PCOS-induced mice model, providing insight into how the condition may alter skeletal integrity.

Read the research: doi.org/10.1530/JOE-25-0292

Journal of Endocrinology logo. New Research. Mitochondrial AR overactivation coupled with uterine decidual mitochondrial defects in PCOS-associated pregnancy loss. By Yuehui Zhang et al. Published by Bioscientifica logo. Society for Endocrinology logo.

Recent research by Yuehui Zhang et al. identifies mitochondrial AR in the uterus and demonstrates that hyperandrogenism-induced, AR-dependent mitochondrial dysfunction in decidual stromal cells is a key mechanism underlying pregnancy loss in PCOS.

Read the full study: doi.org/10.1530/JOE-...

Journal of Endocrinology logo. New Research Fat’s all, folks: culturing and manipulating peri-prostatic adipocytes to probe impacts on prostate cancer biology. By Nil Grunberg et al. Figure 1 Schematic overview of culturing fresh patient peri-prostatic adipose tissue and matched NPAT, isolation of SVF, in vitro differentiation of mature adipocytes and generation of novel immortalised pre-adipocyte cell lines. (i) PPAT and matched NPAT from robotic-assisted radical prostatectomy can be cultured (ii) ex vivo as explants for at least 96 h. (iii) Alternatively, cell-specific effects of mature adipocytes can be studied by isolating SVF and either (iv) culturing primary pre-adipocytes or (v) immortalising primary pre-adipocytes to generate patient-derived cell lines that represent donor- and depot-specific characteristics...Journal of Endocrinology 268, 1; 10.1530/JOE-25-0256 Published by Bioscientifica logo. 80 Years 1964-2026 Society for Endocrinology logo.

A new study by Nil Grunberg et al. outlines a protocol for ex vivo culture of fresh peri-prostatic adipose tissue (PPAT) and non-prostatic adipose tissue (NPAT), which reflects donor- and depot-specific characteristics.

🔓 doi.org/10.1530/JOE-25-0256

Journal of Endocrinology logo. New Research: Leonurine alleviates lung ischemia–reperfusion injury through suppression of ferroptosis via RORα in male mice. By Wanying Chen et al. Figure 1. Effect of LEO on LIRI in mice. (A) Representative H&E-stained images from murine lung tissues after lung ischemia–reperfusion injury (IR) and IR + LEO. Scale bar: 200 μm. (B) Fluorescent images of superoxide levels in murine lung tissues. Superoxide was determined with the fluorescent indicator DHE, and the fluorescent intensity of DHE was observed with a computer-assisted microscope. Scale bar: 200 μm. (C) The lung pathological damage score illustrating the extent of lung injury in different groups. (D) Quantification of the DHE staining in murine lung tissue from (C)...Journal of Endocrinology 268, 1; 10.1530/JOE-25-0298 Published by Bioscientifica logo. 80 Years 1946-2026 Society for Endocrinology logo.

Can leonurine, an alkaloid known for its anti-inflammatory & antioxidant properties, be effective in treating lung ischemia-reperfusion injury?

New research by Wanying Chen et al. explores the therapeutic potential of LEO in a murine model.

🔓 Read the full article: doi.org/10.1530/JOE-25-0298

Journal of Endocrinology logo. New Research. Immunohistochemistry-guided analyses of steroidogenesis in primary bilateral macronodular adrenal hyperplasia. By Sharmilee Vetrivel et al. Published by Bioscientifica logo. Society for Endocrinology logo.

New study by Sharmilee Vetrivel et al. profiles primary bilateral macronodular adrenal hyperplasia (PBMAH) through immunohistochemistry, transcriptomics and exome analysis of 22 PBMAH patients who underwent adrenalectomy.

Explore the research: doi.org/10.1530/JOE-...

Editors' Choice Figure Estrogenic prevention of luteinizing hormone releasing hormone agonist-induced bone loss. By K V Wells et al. Figure 5 Estradiol, not DHT, supplementation restores LHRHa-induced trabecular and cortical bone loss... (B) Representative transverse μCT reconstruction images of distal femoral metaphysis (top), femoral middiaphysis (middle), and L5 vertebrae (bottom). Journal of Endocrinology 267, 2; 10.1530/JOE-25-0315. Paper picked by Journal of Endocrinology Co-Editors-in-Chief: Prof. Ruth Andrew and Associate Prof. Gabriela da Silva Xavier.

We celebrate impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award.

Our 2025 Q4 winner is Figure 5B in 'Estrogenic prevention of luteinizing hormone releasing hormone agonist-induced bone loss' By K V Wells et al.
doi.org/10.1530/JOE-25-0315

Congrats!🎉

Editors' Choice Award. Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. Paper pick by Journal of Endocrinology Co-Editors-in-Chief: Prof. Ruth Andrew and Associate Prof. Gabriela da Silva Xavier. Journal of Endocrinology logo. Trophy icon.

🏆 We're thrilled to award this quarter's Editors' Choice Award to:

Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes.
By Alana Mullins et al.
doi.org/10.1530/JOE-25-0253

Thanks to the authors for your outstanding contribution 👏

Sex Effects in Endocrine Health and Disease. Special Collection. Sex differences in thyroid function: from central regulation to hormone metabolism and disease susceptibility. By Caroline C Faria et al. Journal of Endocrinology logo.

Sexual dimorphism shapes thyroid biology.

A new review by Caroline C Faria et al. highlights how genetic, epigenetic and hormonal differences influence the entire thyroid axis, from central regulation to hormone metabolism.

Explore the article: doi.org/10.1530/JOE-25-0346

Journal of Endocrinology logo. New Research: Effects of combined aerobic and resistance exercise on sarcopenia in elderly patients with type 2 diabetes mellitus. By Yuxia Ma et al. Published by Bioscientifica logo. Society for Endocrinology logo.

Can combined aerobic and resistance exercise improve sarcopenia in older patients with type 2 diabetes mellitus?

A new randomised controlled trial by Yuxia Ma et al. reports encouraging improvements following intervention...

Read the paper to learn more: doi.org/10.1530/JOE-25-0275

Exploring Osteoporosis and Sarcopenia Special Collection. Thyroxine does not improve skeletal muscle regeneration after injury in aged mice. By Thamires Siqueira Oliveira et al. Image is the Graphical Abstract from doi.org/10.1530/JOE-25-0203. Journal of Endocrinology logo.

💪New research by Thamires Siqueira de Oliveira et al. demonstrates that low‑dose thyroxine (T4) replacement does not improve muscle regeneration post-injury in elderly mice. Instead, T4 replacement therapy seemed to induce atrophy & tissue remodeling.

doi.org/10.1530/JOE-25-0203

Journal of Endocrinology logo. New Research. Ambient temperature modulates the effects of peripheral Y1R antagonism on diet-induced obesity and glucose intolerance. By Chenxu Yan et al. Published by bioscientifica logo. Society for Endocrinology logo. Thermometer icon.

New research by C. Yan et al. compared effects of BIBO3304 on diet-induced obesity & glucose intolerance at room temp. (21–22°C) & thermoneutrality (TN, 30°C).

Findings support the temperature-dependent efficacy of metabolic drugs.

Explore the results: doi.org/10.1530/JOE-25-0233

🐾 Does your research explore multifactorial endocrine disorders with domesticated animals as models?

We're dedicating a Special Collection to Comparative Endocrinology. Collection Editors, Dr Eleanor Raffan & Dr Ruth Morgan, welcome submissions of original research & review articles.
bit.ly/3KlpdVZ

Journal of Endocrinology logo. New Review: Pathomechanisms, genetic insights, and therapeutics in diabetes-associated dementia. By Rakesh Meher et al. Published by Bioscientifica logo. Society for Endocrinology logo.

A new review by Rakesh Meher et al. explores the pathophysiological links between diabetes & cognitive decline.

By integrating molecular, genetic and clinical insights, the review highlights how these insights can guide development of personalised dementia therapies.

🔗 doi.org/10.1530/JOE-25-0016

Top right: Journal of Endocrinology. Text reads: New Research. Single-cell analysis of oxidative phosphorylation protein expression in pancreatic islets in type 2 diabetes. By Alana Mullins et al. Figure 1 IsletAnalytics: semi-automated workflow for segmentation of immunofluorescent-stained human pancreatic islets. Data conversion and preparation (stage 1). i) Image acquisition: human pancreatic islet immunofluorescent images are acquired. File conversion: images are converted from czi to .tiff format. Channel splitting: images are processed to split the channels into their respective fluorophores. Iterative Ilastik training (stage 2). ii) Pixel classification: Ilastik’s random forest classifier is used for iterative training to segment complete islets through machine learning-based pixel classification...Journal of Endocrinology 267, 1; 10.1530/JOE-25-0253 Bottom left: Published by Bioscientifica. Bottom right: Society for Endocrinology.

🔬 New study by Alana Mullins et al. introduces IsletAnalytics, semi-automated workflow for segmentation of immunofluorescent-stained human pancreatic islets, revealing altered islet architecture & OXPHOS proteins in T2D β‑cells.

Open-access article: doi.org/10.1530/JOE-25-0253

Journal of Endocrinology logo. 2025 Best Paper Award. Bioscientifica logo. Society for Endocrinology logo.

🪩As we approach the end of 2025, we’re launching the Journal of Endocrinology Best Paper Award.

Join us to celebrate the year’s most outstanding contributions to the field of endocrinology - winners will be announced in early 2026. 🎆

Learn more: joe.bioscientifica.com/page/award/best-paper-award

Rising Stars Special Collection: Effects of a GLP-1 receptor polymorphism on responses to liraglutide in Journal of Endocrinology. By Mona Mashayekhi et al.

New research by M. Mashayekhi (@vanderbilt.edu) et al. explores how the GLP-1R rs6923761 (Gly168Ser) variant modulates response to liraglutide in obesity and pre-diabetes.

🔗Subscribers to Journal of Endocrinology can read the article: doi.org/10.1530/JOE-25-0174

In vivo effects of cadmium on signaling and secretion of pituitary gonadotrophs in male mice are time-dependent. Journal of Endocrinology. By Yorgui Santiago-Andres et al. Figure 1. Effects of cadmium on testicular morphology and function. (A) Representative images of H&E staining on the testes showing structural modifications in the seminiferous tubules. Scale bars: 100 µm. Immunofluorescence analysis of apoptosis in testis sections using an antibody against caspase-3 (green); nuclei were counterstained with DAPI (blue). Scale bars: 200 µm. (B) Cadmium caused hemorrhage in the testes (scale bar shown in cm). (C) Testis weight was significantly reduced after cadmium injection (*P = 0.035, ****P < 0.001; n = 9 for control, 11 for Cd21, 9 for Cd35, and 18 for Cd56). (D) Quantification of sperm cell number in the caudal epididymis (**P = 0.001, ***P = 0.001; n = 7 for control, and 8 for all other groups). (E and F) ... Journal of Endocrinology 267, 1; 10.1530/JOE-25-0161. Published in Bioscientifica. Society for Endocrinology.

☣️ Cadmium, an endocrine disruptor, is a known reproductive toxin.

New research by Yorgui Santiago-Andres et al. reveals the role of cadmium in testicular dysfunction via direct testicular damage & disrupted gonadotroph calcium signalling & hormone secretion.

🔓 doi.org/10.1530/JOE-25-0161

Editors' Choice Figure. Obesity duration is linked to bariatric surgery outcomes via adipose tissue response in Journal of Endocrinology. By Julia Sánchez-Ceinos et al. Figure 2. (F) Schematic representation of significantly up- (red) and down- (blue) regulated proteins in post- vs pre-BS SAT from SSO (left panel) and LSO (right panel) individuals; circle size and the scale in the colour bar represent P value and Log2 (fold change), respectively, while grey connecting lines indicate functional association networks according to STRING. Figure picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.

We recognise impactful figures published in Journal of Endocrinology through our Editors' Choice Figure Award.

Q3 winner: Figure 2F in 'Obesity duration is linked to bariatric surgery outcomes via adipose tissue response'
By Julia Sánchez-Ceinos et al.

doi.org/10.1530/JOE-25-0013

Editors' Choice Award. The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner. By Sekar Galuh et al. Paper picked by: Co-Editors-in-Chief, Professor Ruth Andrew and Associate Professor Gabriela da Silva Xavier.

🏆 We're thrilled to award this quarter's Editors' Choice Award to:

The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner (doi.org/10.1530/JOE-...)
By Sekar Galuh et al.

Thank you to the authors for your contribution!

Sex Effects in Endocrine Health and Disease Special Collection. Intrauterine triclosan exposure disrupts hypothalamus–pituitary–thyroid axis function in offspring rats in Journal of Endocrinology. By Guilherme Henrique et al.

Intrauterine exposure to triclosan, used in personal care products, may increase susceptibility to thyroid hypofunction in adulthood, highlighting its potential role as a developmental thyroid disruptor.

Subscribers to Journal of Endocrinology can read the full article: doi.org/10.1530/JOE-25-0069

Exploring Osteoporosis and Sarcopenia Special Collection. Muscle-bone biochemical crosstalk in osteosarcopenia: focusing on mechanisms and potential therapeutic strategies. By Qinzuo Dong et al. New Review. Journal of Endocrinology.

As part of our Exploring Osteoporosis and Sarcopenia Special Collection, a new review by Qinzuo Dong et al. examines the pathophysiological mechanisms underpinning osteosarcopenia, providing insights that could shape precision targeting.

🔗Subscribers can read the review: doi.org/10.1530/JOE-25-0234