So proud of Summer! I'm sure she will continue to excel in @asinclair.bsky.social's lab!

We’ve got an exciting new thing to share! We have causal evidence (using TMR) that memory reactivation during sleep promotes abstract understanding of underlying structure, allowing transfer learning in a new domain with zero superficial feature overlap with the learned one.

Super excited to share this preprint! How do we disentangle underlying structure from the particular features of a learning episode to benefit future learning? We find that memory reactivation during sleep promotes this structure abstraction process.

www.biorxiv.org/content/10.6...

I wish I could tell all the young eager people who write to me about wanting to do research, or the new novel exciting theory they have developed, that if your email (or worse, theory) was very obviously generated by chatGPT it will be very hard for anybody to take you seriously.

TDLM-Resting-State Simulation How sensitive is TDLM really? Can we actually find replay when we know it is present?

Can we really measure replay in humans using MEG with current methods? In our most recent paper we simulated replay under realistic conditions via a novel hybrid approach with astonishing results.

we're delighted that it has now been published @elife.bsky.social!
elifesciences.org/articles/108...

This manuscript is now available on biorxiv:
www.biorxiv.org/cgi/content/...

The Memory Disorders Research Society (MDRS) is seeking nominations for new members. Self-nominations are welcome! The society is broadly focused on memory research; not just disorders.

Here is the nomination form, which includes info about eligibility criteria: forms.gle/Qn7mchoPpaqL...

MDRS MDRS is a professional society dedicated to the study of memory. Members engage in basic and clinical research into how memory works and why it fails.

The Memory Disorders Research Society (www.memorydisorders.org) is now seeking nominations for new members! Self-nominations are welcome. Application is open until April 15 @ 11:59pm PT.

Reach out if you have questions about the society or its (amazing) annual meeting! forms.gle/Qn7mchoPpaqL...

Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social
#neuroskyence #hippocampus
www.nature.com/articles/s41...

🏳️‍🌈 Is academia truly inclusive for LGBTQIA+ scientists?Join us 24 April at Goethe University Frankfurt (or online!) for a discussion on intersectionality in psychology & neuroscience. Feat. insights from the ALBA global climate survey, the DFG, and community role models.

👉🏾 Register loom.ly/J6arf2g

🗣️ How do institutional and political environments shape scientific careers? A global survey of >400 LGBTQIA+ neuroscientists by members of the ALBA Gender & Sexual Diversity Working Group shows impacts on career decisions, mobility, wellbeing, job satisfaction, safety & inclusion.

👉🏽 loom.ly/AKU04oc

Happy to share some of the work done in our lab in this mega-thread of nine (!) papers/preprints (+1 sneak peek) from the last six months. Here goes (in no particular order)! **Please repost** and let me know if you need access to any of the PDFs! #sleeppeeps #sleep #neuroscience 1/12

And a sneak peek at a paper that is under review & will be preprinted soon (check this space). Sarvia Aquino Argueta found that reactivation during sleep segregates fMRI neural representations of contextually bound memories from one another, effectively leading to decontextualization. 12/12

The effects of targeted reactivation on memories cued once or multiple times during a nap During sleep, memory traces are reactivated and consolidated into long-term memory. Discrete reactivation events involve coordinated activity between …

Matthew Cho set out to examine whether reactivating a memory once or multiple times during sleep would yield different outcomes. Although we didn't find a TMR effect, we found some evidence for a benefit of multiple cues relative to a single one. 11/12

In our most recent preprint, Neda Morakabati trained classifiers to distinguish between words and images of different categories (during wake). This methods paper (and the dataset) should be helpful for any of you deciding which type of stimuli you should use in your sleep/wake decoding study. 10/12

Manipulating memory processing during sleep to explore the critical duration of reactivation events Newly encoded memories are reactivated and consolidated during sleep. However, how the reactivation of a specific memory unfolds over time is poorly u…

Back to sleep: Andrew Lazarus examined the temporal dynamics of single reactivation events by interfering with reactivation shortly after its onset, but found little evidence that long reactivation windows are more beneficial than short ones 9/12

Social, institutional, and political climates shape the experiences and careers of LGBTQIA+ neuroscientists worldwide LGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersex, asexual, and related identities) individuals in science face unique career challenges.…

And now for something completely different: @dpagliaccio.bsky.social, @dgrijseels.bsky.social & I surveyed >400 LGBTQIA+ neuroscientists worldwide, demonstrated that social, institutional, and political climates shape their experiences and careers, & exposed the unique challenges they face. 8/12

Awake reactivation is not a uniform process Memories are consolidated during restful wakefulness, but the mechanisms underlying this process are poorly understood. We argue that wakeful reactiva…

@amirtal.bsky.social and I argue that the literature on awake reactivation is mixed because the extent of processing is rarely measured or manipulated. Elaboration and rehearsal, memory suppression, and nonconscious processing all have different consequences and should be evaluated separately 7/12

Side note: both Gautam & Gayathri found a sustained sigma decline starting after odor onset and lasting well after odor offset. We're still puzzled by these results (using two different setups in two different universities). 6/12

<em>Journal of Sleep Research</em> | ESRS Journal | Wiley Online Library Declarative memories are reactivated—and thereby consolidated—during sleep. Real-life memories are typically nested hierarchically (e.g., memory for making coffee nested within memory for one's morni...

Gautam Narayan was unable to replicate the TMR effects of Rasch (2007) within participants, perhaps because benefits generalized across the learning context rather than impacting a single set of memories 5/12

<em>Journal of Sleep Research</em> | ESRS Journal | Wiley Online Library Reactivation of recently acquired memories during sleep supports their longevity. Reactivation can be altered during sleep using odours or sounds through a technique termed targeted memory reactivati...

Gayathri Subramanian (now a lecturer at @arizonastateuni.bsky.social) discovered that when sounds and odors linked to distinct tasks are co-presented during sleep, this nullifies their targeted benefits, suggesting that unrelated memories can't be simultaneously reactivated. 4/12

In yet another preprint, Tiange (Summer) Lu collaborated with @alexatompary.bsky.social to examine whether sleep promotes generalization in a large online cohort (N=137). Not only did she not find a benefit of sleep, but some evidence also suggested that wakefulness promotes generalization. 3/12

In this preprint, Xuanyi (Lindsay) Lin shows that during sleep, affective networks are not only engaged, but their activity patterns strongly predict depression symptoms, acting as a biomarker for depression & supporting a model whereby maladaptive negative biases are perpetuated during rest. 2/12

Happy to share some of the work done in our lab in this mega-thread of nine (!) papers/preprints (+1 sneak peek) from the last six months. Here goes (in no particular order)! **Please repost** and let me know if you need access to any of the PDFs! #sleeppeeps #sleep #neuroscience 1/12

New preprint! Huge data collection feat from Morgan Barnes and analytic prowess from Thea Ng!

Perturbations of aperiodic activity following learning are reversed in nREM resetting the brain by morning. This reset predicts consolidation!

tinyurl.com/BarnesNg

Isrw group photo

Still pumped up from yesterday's international sleep replay workshop! Provocative talks, engaging discussion groups & enthusiastic engagement by all attendees from undergrads to full professors. Stay tuned for info on the next one. And now, on to @cnsmtg.bsky.social. Check out our lab's posters!

💫 Dr Dori Grijseels, postdoc at MPINB Germany, is the 2026 ALBA-FKNE Diversity Awardee, for their outstanding leadership in advancing inclusive research practices and evidence-based advocacy for queer and trans scientists. Join us on 10 July at #FENS2026 for the award ceremony!

👉🏽 loom.ly/mTiT4f8

Sleep spindles promote hippocampal network downregulation during sleep Sleep is thought to globally downregulate neuronal network activity and synaptic connections enhanced during prior wakefulness and, in parallel, to up…

@currentbiology.bsky.social
I am very happy to share our latest paper, just published in @currentbiology.bsky.social! In collaboration with Olga Garaschuk's lab, we used in vivo 2P calcium imaging to investigate the role of sleep spindles in the hippocampus. 🧠💤
www.sciencedirect.com/science/arti...

Kansas Sends Letters To Trans People Demanding The Immediate Surrender Of Drivers Licenses "The legislature did not include a grace period."

This is bigotry, pure and simple.

open.substack.com/pub/erininth...

The Trump Administration is Testing Conversion Therapy By Medically Experimenting on Trans People in Prisons The Bureau of Prisons is subjecting trans people to conversion therapy and denying them care with the goal of helping them "recover." It's trying to prove dangerous conversion practices can work.

This is a test run, for when they use coercion to force all trans people into conversion therapy. Want rehab for your broken leg? Or insulin for diabetes? You'll have to detransition. transitics.substack.com/p/the-trump-...