Congrats to all authors and collaborators 🇦🇷💞
Damian Refojo, @amarinburgin.bsky.social @skadener.bsky.social, Arierl Chernomoretz, Maxi Beckel, Oli pedroncini, Seba Giusti, Giuli Di Mauro, Iva & @inespatop.bsky.social
Very happy to see the last piece of my PhD out!!!😊
Great collaborative work at IBioBA-Max Panck partner Institute in Buenos Aires!🇦🇷🏄♂️
"Neuronal activity-dependent gene expression is stimulus-specific and changes with neuronal maturation" (doi.org/10.3389/fnmo...)
New paper from our lab!
Happy to contribute to this collective effort, advancing our understanding of DDX3X and its role in #DDX3Xsyndrome
Cortico-brainstem neurons of Ddx3x mutant female mice have altered laminar position and expression of CTIP2 and BRN1. (A) Retrograde tracing of cortico-brainstem neurons reaching the pons. Subpanel a, schematics of the coronal plane corresponding to the site of injection of rAVV-CAG-GFP (pontine reticular nucleus, PNRr), including a sagittal view. Subpanel b, coronal section of a brain 3 weeks after the stereotaxic surgery, showing the ipsilateral labeling of neurons extending axons from the MOp and SSp to the brainstem. Subpanel c, sagittal section of a brain 3 weeks after the stereotaxic surgery, as in subpanels a and b.
#DDX3X syndrome is a rare neurodevelopmental disorder affecting motor & cognitive functions. Using a mouse model of DDX3X 🐭 , Michael Flores & co investigate how the development and circuit organization of a layer five neuronal subpopulation in the cortex is disrupted. doi.org/10.1242/bio....
Huge thanks to the incredible co-authors for their collaboration. Great multidisciplinary team!
@msbeckel @OPedroncini @SebasGiusti @Ivanaml_ @inespatop.bsky.social @achernom.bsky.social @amarinburgin.bsky.social @skadener.bsky.social @IBioBA_MPSP
😊🔬 Happy to share our preprint manuscript from my PhD! This study sheds light on stimuli specific activity-dependent gene expression and its changes during neuronal development in vitro. Looking forward to discussions and new perspectives!
#ACNP2024
@nikosdaskalakis.bsky.social introduced part of my work during his talk. Stop by my poster T130 tomorrow Tuesday 5-7pm for a chat and more insights. 🧠🫧