🔬 We’re recruiting: Translational Research Scientist (Cell Therapy Manufacturing)

Join the Jenkins Lab at WEHI and be at the forefront of research in immunotherapy for brain cancer.

For full details and to apply visit: wehi.wd3.myworkdayjobs.com/WEHI/job/Par...

Code to complex: AI-driven de novo binder design In this review, Fox et al. discuss how artificial intelligence has transformed our ability to design new-to-nature proteins that bind target proteins with high affinity and specificity. The authors de...

Excited to share our new review on AI-driven protein design - from its origins to today’s breakthroughs, methods, potential, and challenges ahead !

www.cell.com/structure/fu...

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

🥳🥳🥳

New to nature proteins are the future! Proud to have contributed to this groundbreaking work! 🏴‍☠️

Lab Heads positions are available at our institute in beautiful Melbourne! 👇🏻

Happy democracy sausage day Australia 🇦🇺!

Atom level enzyme active site scaffolding using RFdiffusion2 De novo enzyme design starts from ideal active site descriptions consisting of constellations of catalytic residue functional groups around reaction transition state(s), and seeks to generate protein ...

RFdiffusion ✌🏻

www.biorxiv.org/content/10.1...

What a fantastic opportunity!

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development, yet the design of protein agonists and antagonists has been challenging as ...

Many familiar names from labs in Australia in this exciting preprint! Congratulations!!!

www.biorxiv.org/content/10.1...

Netflix’s #Adolescence is a masterpiece that everyone should watch.

We are recruiting a group leader in laboratory research at Peter Mac Cancer Centre in
Melbourne, Australia 🔬🦘💥

Work in a cutting edge research environment in a vibrant world city!

We value research excellence, creativity and diversity.

Join us!

careers.petermac.org/job/MELBOURN...

Atomically accurate de novo design of antibodies with RFdiffusion Despite the central role that antibodies play in modern medicine, there is currently no method to design novel antibodies that bind a specific epitope entirely in silico. Instead, antibody discovery c...

Check out the updated version of the de novo Ab design preprint 👇🏻

www.biorxiv.org/content/10.1...

Hilarious

BindCraft: one-shot design of functional protein binders Protein–protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present B...

In case you missed the BindCraft paper 👇🏻.

www.biorxiv.org/content/10.1...

Beautiful Bundoora campus 😍!

Today marks 10 years since I moved to Australia! Can’t think of a better place to be. Back to where it all started @lorneproteins.bsky.social

De novo design of protein minibinder agonists of TLR3 - Nature Communications This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting they ...

De novo design of protein minibinder agonists of TLR3. Congrats to the authors!

www.nature.com/articles/s41...

Quinone extraction drives atmospheric carbon monoxide oxidation in bacteria - Nature Chemical Biology Here, Kropp et al. use cryo-electron microscopy and structural modeling to show that the enzyme [MoCu]-CO dehydrogenase interacts with its partner, the membrane-bound quinone-binding protein CoxG, to ...

In Nature Chemical Biology today, we reveal how microbes clean our atmospheres by consuming carbon monoxide (CO) gas. A methodological tour de force from Ashleigh Kropp, Rhys Grinter, and David Gillett with broad implications for the atmosphere and bioenergetics. www.nature.com/articles/s41...

Congrats to you and your team! 🍾

De novo designed proteins neutralize lethal snake venom toxins - Nature Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...

“De novo designed proteins neutralize lethal snake venom toxin” paper from the Baker lab just published in Nature.

www.nature.com/articles/s41...

New year, new #Lego flowers for the office. 😍

Lorne Protein Meeting poster

Interactive Program now live for the Lorne Protein Conference 2025! Merry Christmas and Happy New Year!
www.lorneproteins.org

Development of a De Novo Protein Binder that Inhibits the Alpha Kinase eEF2K Elongation factor 2 kinase (eEF2K) is calmodulin activated and phosphorylates eEF2, a GTPase, that regulates global translation. When eEF2K phosphorylates eEF2, protein translation is halted. This pro...

To get the things going on this platform, I decided to start sharing some interesting de novo protein design papers! Hope you find them useful!

www.biorxiv.org/content/10.1...

Australia's got de novo binders! 🎉 Congrats to @danielrfox.bsky.social @rhyswg.bsky.social, @cyntiat.bsky.social, @gavinjknott and all authors on their incredible work featured in two preprints below.
Thrilled to have contributed to the ChuA story, such an exciting advance in Protein Biochem!