Intravital microscopy image of an inflamed blood vessel in the liver of a mouse. A single platelet is attached to the vessel wall and releases a long, thin membrane tether enriched in integrins and tetraspanins, while the platelet body detaches and moves back into the bloodstream.
🥂 Our paper on #platelet derived integrin- and tetraspanin-enriched tethers (PITTs) is out in #Science. 🥳
Non-activated platelets shed αIIbβ3-rich tethers that amplify inflammation while impairing platelet function. Huge thanks to all co-authors!
🔗 doi.org/10.1126/scie...
#ThromboInflammation
2 months ago
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