Optogenetic control of mechanotransduction based on light-induced homodimerization of talin Integrin-based adhesion complexes serve as primary sites for actomyosin force transmission to the extracellular matrix, providing traction that drives cell mechanical responses including adhesion, mig...

Optogenetic control of mechanotransduction based on light-induced homodimerization of talin url: journals.biologists.com/jcs/article-...

We've integrated FRAP, HILO, and TIRF microscopy into a single setup, driven entirely by a single SLM. Check out the details! #Microscopy #CellBiology #OpticsExpress
opg.optica.org/oe/fulltext....

This blowing my mind 🧪

🚨Job Alert: My department in UNSW Sydney is recruiting a teaching-only Lecturer in Biophysics. The lecturer will play a key role in the pedagogical development and delivery of courses and practicals in the new undergraduate (BSc) major in #Biophysics that we are launching from 2026. #AcademicBsky 🧪

Pleased to share that a SLM can achieve multiple FRAP to HILO to TIRF. biorxiv.org/content/10.1... (to appear in Opt Exp opg.optica.org/oe/home.cfm). Great work done by Avinash www.linkedin.com/in/avinash-u...
and Daniel linkedin.com/in/daniel-li... from the team.

We are recruiting for an academic position (Assoc Prof/Prof) in Optical and Photonic Engineering in Oxford. Please share.
Closing date 9 September 2025.
my.corehr.com/pls/uoxrecru...

WAVE complex forms linear arrays at negative membrane curvature to instruct #lamellipodia formation, say Muziyue Wu, Orion Weiner @oweinerlab.bsky.social and colleagues: rupress.org/jcb/article/...

#Biophysics #Cytoskeleton #Migration #Motility #Actin

Publishing scientific papers is an obstacle course. There are many aspects to this but lengthy review times are one. That's why I am very excited about the new initiative @biologyopen.bsky.social, @biologists.bsky.social open access journal: Fast & Fair 1/n 🧪
journals.biologists.com/bio/pages/fa...

Curvature feedback for repetitive tissue morphogenesis – Bridging algorithmic principles and self-regulatory systems Tissue patterning during organ development consists of intricate morphogenetic processes, driven by the interplay of physical and genetic cues among c…

Excited to share our new review with Emmanuel on tissue patterning in organ morphogenesis! We explore how repetitive patterns form, starting with the concept of L-systems and highlighting an ERK-mediated curvature feedback. Please check it out! sciencedirect.com/science/arti...

Join us in Singapore in September for the "Mechanobiology in Time and Space" meeting hosted by the Mechanobiology Institute at NUS @mbisg.bsky.social and Max Planck Society @maxplanck.de. Abstracts due soon! www.mbi.nus.edu.sg/events/mbico...

Combining Multi-site FRAP and HILO-TIRF microscopy using a Spatial Light Modulator www.biorxiv.org/content/10.1101/2025.04....

Adaptive Optics summer school - early registration deadline coming up on 14 April. Register soon to get reduced price.

📝 New preprint! 📝
Happy to share a new preprint from @kimboonekamp.bsky.social and me: We developed a 3D force inference method for budding organoids!
biorxiv.org/content/10.1...
From the labs of @ulrichschwarz.bsky.social and
@michaelboutros.bsky.social with help from U. Engel.
Here the details.

Getting tissue stress from images is tough, and elastic tension sensors are a way to solve this. Still, the analysis is complex. Try our GUI gitlab.gwdg.de/betzlab_publ... implementing analytical solutions to obtain surface stresses AND shape parameters of beads and nuclei.

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning - Nature Neuroscience Researchers developed DELTA, a method for brain-wide measurement of synaptic protein turnover with single-synapse resolution, providing a powerful tool to localize and study mechanisms underlying syna...

Also check out the related work led by Boaz Mohar. Pulse-chase labeling with permeable HaloLigand dyes probes protein turnover. www.nature.com/articles/s41...

Imaging throughput of compact handheld microscopes for quantitative single cell studies www.biorxiv.org/content/10.1...
Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions www.biorxiv.org/content/10.1...

it was fun and engaging....

Great to be part of a fantastic community event with so much more to discover! Great science and fun Thanks to Leslie Yeo, Dario Carugo, Jessie Jeon, Christoph Westerhausen & @dfrivas.bsky.social
for putting together such a wonderful meeting on high frequency mechanostimulation #sonomechanobiology

Imaging throughput of compact handheld microscopes for quantitative single cell studies www.biorxiv.org/content/10.1101/2025.03....

Using rotational integration of oblique interferometric scattering (RO-iSCAT) to track axial spatiotemporal responses of membrane protrusions www.biorxiv.org/content/10.1101/2025.03....

Just a start! Who's missing?

go.bsky.app/LAA7Sdx

Ability Optics lights up a faster, clearer future for biotech ANU spinoff company Ability Optics Pty Ltd is accelerating to revolutionise biotechnology with an aim to speed up early lead drug screening by 100-fold.

Thanks! Calo @jcsmr.bsky.social for highlighting this exciting venture bit.ly/AOaccel 🎉

Our new OPM system, in which the camera is placed directly after the secondary objective to directly detect the oblique plane.

In our work, we just put the camera directly into the remote refocus volume to detect the oblique plane directly, without the need for a tertiary microscope system!

I have seen this change the lives of many students and postdocs--if you are interested in cell biology, biophysics, microscopy or more: check this out! The Embryology course is also similarly life-changing

Interesting findings by Jacob Notbohm's group. Nematic defects may form as a result of spatially coordinated patterns in cell forces and motion.
👉 arxiv.org/abs/2501.04827

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Courses Intent to Apply Form Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Hey PIs, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available.
meetings.cshl.edu/coursesinten...

Flyer about POM: no fees for registration

Photonics Online Meetup (POM23) is a little over a wk away!

Don't forget to register (for free!) to join on Gathertown for live streaming, posters, & more.

Optica student chapters: apply for funding to support a Hub!
#OpenAccess #free #SciSky #Acadsky
photonicsonlinemeetup.org/registration/

🧪 💡