Advertisement · 728 × 90

Posts by Phil Hugenholtz

The object that he showed me

3 days ago 0 0 0 0
GTDB - Genome Taxonomy Database The Genome Taxonomy Database (GTDB) is an initiative to establish a standardised microbial taxonomy based on genome phylogeny.

GTDB release 11 based on RefSeq 232 (R11-RS232) is live at gtdb.ecogenomic.org. This release covers 901,341 genomes (23% increase) and has 199,923 species clusters (39% increase). Release notes at: forum.gtdb.ecogenomic.org/t/announcing.... Release statistics at: gtdb.ecogenomic.org/stats/r232.

6 days ago 49 29 0 5

That’s what we say, only 6 months earlier 😂

5 days ago 4 0 0 0

It’s the binchicken effect

6 days ago 1 0 1 0

The answer can now be found at gtdb.ecogenomic.org

6 days ago 2 0 1 0

Thermoaminiphila catenidiffluenda gen. nov., sp. nov.: A novel thermophilic, strictly anaerobic bacterium representing Thermoaminiphilia class nov., a newly described class thriving in hydrocarbon-rich habitats and biogas fermenters www.biorxiv.org/content/10.6... #jcampubs

6 days ago 3 1 0 0

Immensely rewarding part of this work was working with Indigenous language experts and elders in the naming of our species of Asgard….’marumarumayae’ derived from the Malgana language from the people of Gathaagudu (#Shark Bay)

1 week ago 8 6 1 0

Ecology of metagenomes: incorporating genotype-to-phenotype maps into ecological models www.biorxiv.org/content/10.6... #jcampubs

1 week ago 14 2 0 0
Genome Download a genome data package including genome, transcript and protein sequence, annotation and a data report

Notice for users submitting MAGs to INSDC

Issue: MAGs submitted to INSDC without taxonomic annotations, typically listed as ‘metagenome’, are not included in GTDB. Examples: www.ncbi.nlm.nih.gov/datasets/gen...

What to do: Provide at least a domain-level taxonomic affiliation in the Taxon field.

1 week ago 8 7 1 0
Advertisement

Our work on 'hidden diversity' in unbinned contigs is now published in @natmicrobiol.nature.com :

www.nature.com/articles/s41...

See the linked threads for more details!

2 weeks ago 67 40 3 1
MBE Call for Papers on the Major Transitions of Life

MBE Call for Papers on the Major Transitions of Life

MBE is excited to launch our newest Call for Papers on the Major Transitions of Life, covering all aspects of phylogenomic research.

🔗 academic.oup.com/mbe/pages/call-for-papers-on-the-major-transitions-of-life

Guest Editors:
Davide Pisani
Anja Spang

#evobio #molbio #phylogenetics

2 weeks ago 23 14 1 0
Preview
Micro-scale spatial metagenomics opens a new era in microbiome ecology Understanding microbial communities requires moving beyond 2D representations toward a holistic view that couples 3D spatial organization with ecological function, integrating microbial inventories, g...

Micro-scale spatial metagenomics opens a new era in microbiome ecology

@cp-trendsmicrobiol.bsky.social Opinion from @mizrahilab.bsky.social

www.cell.com/trends/micro...

2 weeks ago 25 12 2 1

Metagenomic mining reveals extensive novelty, enhanced biodegradation potential, and untapped biosynthetic capacity in Chinese oilfield microbiomes journals.asm.org/doi/full/10.... #jcampubs

2 weeks ago 6 2 0 0
Preview
Redox chemistry of early Earth and the origin of life - Communications Chemistry Redox reactions played an important role in shaping the conditions that enabled the emergence of life on the early Earth, but how these relate to specific environmental conditions and whether they led...

Redox chemistry of early Earth and the origin of life www.nature.com/articles/s42... #jcampubs

2 weeks ago 32 15 0 1
Figure 1 shows the conceptual workflow of the algorithm. It first loads the configuration file and the input data of one or multiple binned metagenomes, yet evaluates each bin individually. It then iteratively processes each candidate bin in the input, going through the refinement tasks, potentially multiple times. The refinement either stops when the last step or a preset stop task have been reached or an unrecoverable error has been encountered. The algorithm tasks can be configured individually.

Figure 1 shows the conceptual workflow of the algorithm. It first loads the configuration file and the input data of one or multiple binned metagenomes, yet evaluates each bin individually. It then iteratively processes each candidate bin in the input, going through the refinement tasks, potentially multiple times. The refinement either stops when the last step or a preset stop task have been reached or an unrecoverable error has been encountered. The algorithm tasks can be configured individually.

🤯 Manual MAG refinement? Still doing it by hand??

We’ve been there... You could just leave those messy, ill-assigned contigs/scaffolds in your data for NCBI to pick up during your submission…

…OR you could add itBins, our new automated MAG refiner by @jmk-ude.bsky.social, to your pipeline!! 🔥

2 weeks ago 12 7 1 0
SeqCode Prize | SeqCode Registry

The SeqCode Committee has opened the call for applications to the SeqCode Prize 2026, sponsored by ISME.

@isme-microbes.bsky.social

2 weeks ago 1 4 1 0

Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social

Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback.

rdcu.be/famFj

3 weeks ago 98 56 4 1
Post image

How much protein diversity can Life on Earth actually generate?

With DIAMOND DeepClust, we show how billions of proteins across the tree of life can be clustered at low-identity for downstream analytics tasks.

📚Paper: www.nature.com/articles/s41...
💻Code: github.com/bbuchfink/di...

4 weeks ago 64 29 1 0
Advertisement
Preview
Aerobic sister lineage of breviates has gene-rich mitochondrial genomes Cho et al. describe a novel, aerobic sister lineage of Breviatea using flow cytometric single-cell sorting and genome amplification. The new lineage harbors gene-rich mitochondrial genomes, unlike Bre...

Aerobic sister lineage of breviates has gene-rich mitochondrial genomes
#microbiology #eukaryotes #mitochondria #protists #MicroSky #ProtistsOnSky
@cellpress.bsky.social
www.cell.com/current-biol...

4 weeks ago 12 8 1 0

New paper in mSystems! 🧵 - how much of your metagenome is actually bacterial/archaeal DNA? For many samples, nobody knows.

We built SingleM prokaryotic_fraction (SPF) to answer this, then ran it on >100,000 public metagenomes. 🧬🖥️🦠

Here's what we found 👇
doi.org/10.1128/msystems.01062-25

4 weeks ago 46 28 1 2
Post image Post image

A novel planctomycetotal isolate from subsurface percolates belongs to the novel species Anatilimnocola aquadivae sp. nov. in the family Pirellulaceae
#microbiology #bacteria #NewSpecies #taxonomy #MicroSky
doi.org/10.1038/s415...

4 weeks ago 6 2 1 0
Image of the cover of the 1st volume of ISME Host Microbe a new official journal of the International Society for Microbial Ecology. Cover images shows a plant stomata with bacteria around and entering.

Image of the cover of the 1st volume of ISME Host Microbe a new official journal of the International Society for Microbial Ecology. Cover images shows a plant stomata with bacteria around and entering.

Excited to announce our new journal from @isme-microbes.bsky.social ISME Host Microbe is live and now accepting submissions. Look forward to receiving your papers! #Microsky 🧫 🦠

1 month ago 120 82 3 1
Preview
Automated genome mining predicts structural diversity and taxonomic distribution of peptide metallophores across bacteria Automated detection of metallophore biosynthesis reveals that metal-chelating non-ribosomal peptides are widespread, chemically diverse, and deeply rooted in bacterial evolution.

Are you interested in how to predict functions of natural product biosynthetic gene clusters (BGCs) and their products? And/or do you love metallophores and would love to identify their producers in microbiomes? Check out @zachreitz.bsky.social 's new paper!
elifesciences.org/articles/109... 1/n

1 month ago 27 12 4 1

The recovery of 12,789 genomes revealed the diversity, function, and microbial interactions of the geothermal spring microbiome www.biorxiv.org/content/10.64898/2026.03...

1 month ago 3 2 0 0

A very good likeness!

1 month ago 0 0 0 0
Post image

Genomic insights into adaptation and microevolution of two novel non-AOA #Nitrososphaeria, Acidarchaeum fankouense and Thermosulfuris yongpingense, in acid mine drainage ecosystems www.sciencedirect.com/science/arti...

1 month ago 5 4 0 0
Advertisement

Oops, typo in the family name in the abstract

1 month ago 0 0 0 0
Post image

Apolloniradiicaulis salifontis gen. nov., sp. nov., a New Prosthecate Aerobic Anoxygenic Phototroph Isolated from Lake Winnipegosis Region Salt Springs
#microbiology #NewSpecies #taxonomy #MicroSky
doi.org/10.3390/micr...

1 month ago 3 2 2 0
Preview
Thermophilic bacteria employ a contractile injection system in hot spring microbial mats Abstract. Bacterial contractile injection systems (CISs) are multiprotein complexes that facilitate the bacterial response to environmental factors or inte

Thermophilic bacteria employ a contractile injection system in hot spring microbial mats
#microbiology #thermophiles #bacteria #MicroSky
@isme-microbes.bsky.social
doi.org/10.1093/isme...

1 month ago 9 4 1 0
Preview
Diversity, ecology, cell biology and evolution of the Asgard archaea Nature Reviews Microbiology, Published online: 05 March 2026; doi:10.1038/s41579-026-01288-wThe Asgard archaea have become a cornerstone of archaeal research, particularly for studies aiming to unravel the origin and early evolution of eukaryotes. This Review outlines the current state of the research field focusing on these intriguing microorganisms and discusses future research directions aiming to resolve their diversity, ecology, cell biology and evolution.

New online! Diversity, ecology, cell biology and evolution of the Asgard archaea

1 month ago 13 4 0 0