Functional synaptic connectivity shapes spine stability in the hippocampus - Nature Communications In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...

www.nature.com/articles/s41...
Two-author papers are always special.
Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅

Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Thrilled to see our paper published! I’m deeply grateful to the amazing @ggirardeau.bsky.social for trusting me to develop and carry it out. Many thanks as well to @azulsilva.bsky.social , @belalima-paiva.bsky.social and Eleonore for driving this work forward together.
www.nature.com/articles/s41...

A population approach to cortical GABAergic interneuron function Inhibitory interneuron diversity is a central feature of cortical circuits. The IN-CODE consortium seeks to combine large-scale recordings of interneuron types with machine-learning tools to identify ...

A population approach to cortical GABAergic interneuron function: Neuron www.cell.com/neuron/fullt...

‘RAMmageddon’ hits labs: AI-driven memory shortage is impacting science The soaring cost and limited supply of computer memory is slowing some projects — and spurring creative approaches.

The shortage of random access memory chips, which has caused prices to soar, has pushed some scientists to revisit how they do their work.

go.nature.com/4rtUkhm

Single-celled organism with no brain is capable of Pavlovian learning A trumpet-shaped, single-celled organism seems able to predict one thing will follow another, hinting that such associative learning emerged long before multicellular nervous systems

This is an awesome discovery:
A single-celled organism with no brain called Stentor seems capable of Pavlovian learning. Yes, it can actually learn to associate two things despite having no neurons.

My latest for @newscientist.com. 🧪 #science #memory #learning
www.newscientist.com/article/2519...

How birds detect Earth’s magnetic field

This study suggest a model whereby electromagnetic input from the semicircular canals activates a vestibular-mesopallial circuit in the pigeon brain

www.science.org/doi/10.1126/...

Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
www.nature.com/articles/s41...

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

Improved spatial memory in a modular network mimicking the prefrontal-thalamo-hippocampal triangular circuit www.biorxiv.org/content/10.64898/2026.02...

La @semaineducerveau.bsky.social arrive bientôt au SPPIN !

Nous avons le plaisir d’accueillir une conférence suivie d’une visite du laboratoire par @uligraupner.bsky.social dédié aux approches optogénétiques pour comprendre les circuits neuronaux et le comportement.

'Developmental perspectives on spatial navigation: sensory development, experience, and neuronal heterogeneity'

by Xiaojing Chen, Liming Tan & Cheng Wang

www.cell.com/trends/neuro...

🎉 PhD defended on Dec 5! Feeling so happy. Many thanks to my supervisors @schlab.bsky.social and @desdemonafricker.bsky.social as well as my jury members and colleagues.
I studied how novelty shapes hippocampal computations using Neuropixels.
Now looking for a postdoc. Excited for what's next! 🚀

Communiqué de 30 associations du Collège des sociétés savantes, relatif à la situation à Gaza
societes-savantes.fr/communique-de-29-associa...

Christian Mayer - Origins of Inhibitory Neuron Identity in the Deve

Monday, December 15, 2025 - Paris Brain Institute (Auditorium)

Episode #34 in #TheoreticalNeurosciencePodcast: On balanced neural networks – with Nicolas Brunel

theoreticalneuroscience.no/thn34

Cortical neurons seem to receive about the same amount of excitation and inhibition. One of the founders of this key idea in 1990s explains.

Diving in with Nachum Ulanovsky With an eye toward realism, the neuroscientist, who has a new study about bats out today, creates microcosms of the natural world to understand animal behavior.

Naturalistic approaches such as Ulanovsky’s open up “potential opportunities to really reveal why the brain is structured in the way it’s structured,” says Iain Couzin.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/neuroetholog...

Thanks to the Capitainerie de l’Isle and to Nathalie for hosting our exhibit ✨

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬:
🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0
🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

🎨🔬 Quand l’art rencontre la science !

Le SPPIN est heureux de vous annoncer l'Expo #SciArt “Regards Croisés” avec l’artiste Sophie Sainte-Marie-Heim et notre collègue @desdemonafricker.bsky.social

🗓 22–28 sept. 2025
📍 Capitainerie de l’Isle, 26 rue Chanoinesse, Paris 4e

Venez nombreux !

𝗪𝗵𝗮𝘁'𝘀 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗶𝘀 𝗶𝘁 𝗲𝗺𝗲𝗿𝗴𝗲𝗻𝘁?
Don't miss the Neuroscience and Philosophy Salon.
Earl Miller and team will discuss recent paper and we'll have plenty of discussion. Open to all.
Sept 12, noon EST-US
umd.zoom.us/meeting/regi...
#neuroskyence
@earlkmiller.bsky.social

A Neural Compass in the Human Brain during Naturalistic Virtual Navigation A central component of wayfinding is the ability to maintain a consistent representation of one's facing direction (FD) when moving about the world. In rodents, head direction cells are believed to su...

Successful wayfinding requires an "internal compass" – a representation of the direction we're facing. Where is this internal compass in the brain?

When humans navigate a virtual city, the retrosplenial complex & superior parietal lobe keep track of facing direction across distinct environments.

The new issue is out👉https://www.cell.com/cell/current
⁠
On the cover, Eliav et al. reveal that hippocampal replays in bats flying in very large, naturalistic environments were highly fragmented and short, depicting trajectories covering only a small portion of the environment size.

Task engagement differentially drives hippocampal and neocortical neural codes Sensory inputs are progressively transformed into internal representations of the environment along the cortical hierarchy. How does the behavioral relevance of these inputs affect this encoding? Usin...

The main project from my PhD, in collaboration with Manuela Allegra and @schlab.bsky.social is now available as a preprint! We wondered how the hippocampus and the visual cortex may differ in the way they refine sensory inputs into internal representations

Event structure sculpts neural population dynamics in the lateral entorhinal cortex Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...

Your brain doesn’t just passively track time ⏳ - it structures it.
In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2)

👉 www.science.org/doi/10.1126/...

An illustration of a mouse on a ball looking at a field of grass displayed on monitors.

Can your AI beat a mouse?

Mice still outperform our best computing machines in some ways. One way is robust visual processing.

10 years ago I decided to work on HARD behavior driven by COMPLEX visual processing. And that risk is paying off now. #neuroAI 1/n

Large-scale high-density brain-wide neural recording in nonhuman primates - Nature Neuroscience Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Neuropixels 1.0 NHP: a 45 mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain

www.nature.com/articles/s41...

🚨New in @cellpress.bsky.social
We discovered that hippocampal replays in natural-scale environments are highly fragmented, not full-length.
doi.org/10.1016/j.ce...
👇🧵

GitHub - Julie-Fabre/bombcell: Automated quality control, curation and neuron classification of spike-sorted electrophysiology data Automated quality control, curation and neuron classification of spike-sorted electrophysiology data - Julie-Fabre/bombcell

🚀 We are excited to share that bombcell is now available in Python! 🐍 Automatically sort your units into good/MUA/noise/non-somatic using quality metrics and interpretable & adjustable classification thresholds.
pip install and play around with our toy dataset:
🔗 github.com/Julie-Fabre/...

Formation of an expanding memory representation in the hippocampus - Nature Neuroscience Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases and suggests novel me...

Multiday imaging of CA1 neurons during learning reveals that the representation stabilizes as the number of readily retrievable, information-rich and stable place cells increases, and suggests novel mechanisms of hippocampal memory formation

www.nature.com/articles/s41...