So delighted to have been awarded 1st place for my PhD work at the @imperialnhli.bsky.social NHLI presentation day! Thank you to my brilliant supervisors - Prof Sanjay Prasad, @drdeclanoregan.bsky.social, @jamesware.bsky.social and @doctorpaz.bsky.social - for all their incredible support! 🫀🧬📈🥳

5!

🚨Our double header on genetics of hypertrophic #cardiomyopathy out today in @naturegenet.bsky.social 🧬

📍GWAS www.nature.com/articles/s41...
📍polygenic scores www.nature.com/articles/s41...

A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel

Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…

Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29

Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...

Covers of Science and Nature journals in the past 2 weeks denoting remarkable progress of life science with A.I. tools

A vertical takeoff of life science with #AI LLLMs.
Publication of 10 new foundation models of Proteins, DNA, RNA, methylation, cells, and interactions, evolution, and design in the past couple of weeks!
Unprecedented progress, reviewed in the new Ground Truths
erictopol.substack.com/p/learning-t...

🫀New paper by @kathrynmcgurk.bsky.social with @drdeclanoregan.bsky.social published today in
@natureportfolio.bsky.social describes the genetic architecture of myocardial trabeculae - the network of muscle fibres in the heart.🫀

@imperialnhli.bsky.social @thebhf.bsky.social

#Medsky #Cardiosky 🧪

Congratulations- amazing work!! 🧬🎉

🧬 Our dilated #cardiomyopathy GWAS out today!

📍https://www.nature.com/articles/s41588-024-01952-y

All made possible with friends and collaborators from HERMES Consortium @alberthenry.bsky.social @tomlumbers.bsky.social @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social #BHF

🧵 👇

—Please give me an A.I. that automatically detects, interprets all types of medical. images (scans, retina, endoscopy, skin) that I can interact with, can integrate data from other sources, saves a lot of time, and improves accuracy
—Sure, here it is
www.nature.com/articles/s41...

Genetic and phenotypic architecture of human myocardial trabeculation - Nature Cardiovascular Research The inner surface of the heart has a meshwork of muscles called trabeculae. McGurk et al. report the genetic regulation of these complex structures across common and rare variants, revealing pathways ...

New paper out in @natureportfolio.bsky.social by @kathrynmcgurk.bsky.social on the genetic architecture of myocardial trabeculae. @mrc-lms.bsky.social www.nature.com/articles/s44...

Exciting first bluesky post! We estimated trabecular complexity in 50,000 UK Biobank participants to identify influencing genetic, clinical, and lifestyle factors. Trabeculation progresses with cardiac diseases and changes can occur early in pathogenesis.