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Posts by Sander van Bree

If you're looking for a PhD position, I recommend this. Benedikt is great to work with!

3 hours ago 3 0 0 0
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TDLM-Resting-State Simulation How sensitive is TDLM really? Can we actually find replay when we know it is present?

Can we really measure replay in humans using MEG with current methods? In our most recent paper we simulated replay under realistic conditions via a novel hybrid approach with astonishing results.

we're delighted that it has now been published @elife.bsky.social!
elifesciences.org/articles/108...

1 week ago 70 33 3 5
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📢 PhD position in the NeuroAI of Language

Why can LLMs predict brain activity so well? We're hiring a PhD student to find out -- AI interpretability meets neuroimaging
Deadline March 20
Please RT 🙏
👇
mpi.nl/career-education/vacancies/vacancy/fully-funded-4-year-phd-position-neuroai-language

1 month ago 50 40 2 1

Original is from 2021. Still relevant 🧠🟦 🧪

I wonder how many kinds of templates would be needed to capture most “canned” cog/neuro science out there…

2 months ago 9 1 0 0

🧨 Preprint alert
Is it easier to find a ball than a shoe? The answer lies in how variable we think these objects are in the real-world. www.biorxiv.org/content/10.6...

w/ the amazing @dkaiserlab.bsky.social & @luchunyeh.bsky.social 🦄

🧵1/8

2 months ago 20 8 1 2
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New PhD and post-doc job openings!

Join me and Prof. Nina Kazanina @ Uni Geneva, Switzerland, to take part in an exciting project on relations and binding in language and vision, explored with cutting-edge neurophysiology (#iEEG and MEG).

Full details in the job offer below.

2 months ago 28 18 1 4

Finally out in eLife!!
"Early foveal cortex predicts the features of saccade targets through feedback from higher cortical areas."
elifesciences.org/articles/107...

2 months ago 30 11 0 0
Poster advertising symposia on Frances Egan’s book ‘Deflating Mental Representation’ (13/04 - 15/04). More info: https://tinyurl.com/NMO-ISPSM and https://tinyurl.com/Phimisci-Egan

Poster advertising symposia on Frances Egan’s book ‘Deflating Mental Representation’ (13/04 - 15/04). More info: https://tinyurl.com/NMO-ISPSM and https://tinyurl.com/Phimisci-Egan

🔔✨Call for papers and symposia on Frances Egan’s (@francesegan.bsky.social) ‘Deflating Mental Representation’ (13/04 - 15/04) alongside Neural Mechanisms Online and Philosophy and the Mind Sciences (@phimisci.bsky.social)!

More info: tinyurl.com/NMO-ISPSM and tinyurl.com/Phimisci-Egan

#philsky

3 months ago 16 10 1 0
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main goal for this year: find a new job! 🙂

looking for a role with fun & complex technical challenges & within a great community. my main expertise is in signal processing/EEG/MEG, but topic-wise I am quite flexible.

science/industry both great! starting mid-year. nschawor.github.io/cv

3 months ago 102 66 3 3
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New preprint: Inference over hidden contexts shapes the geometry of conceptual knowledge for flexible behaviour.

In this pre-reg study, our core claim was that we don’t just learn stimulus-reward. We infer hidden context and that inference re-wires attention and neural state space on the fly.
1/8

3 months ago 36 16 1 0
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Dispute erupts over universal cortical brain-wave claim The debate highlights opposing views on how the cortex transmits information.

A “universal” pattern of cortical brain oscillations may be less ubiquitous than previously proposed.

By @claudia-lopez.bsky.social

#neuroskyence

www.thetransmitter.org/brain-waves/...

4 months ago 33 12 1 1

Good postdoc opportunity ⬇️

4 months ago 2 0 0 0
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Lindsay Lab - Postdoc Position Artificial neural networks applied to psychology, neuroscience, and climate change

Spread the word: I'm looking to hire a postdoc to explore the concept of attention (as studied in psych/neuro, not the transformer mechanism) in large Vision-Language Models. More details here: lindsay-lab.github.io/2025/12/08/p...
#MLSky #neurojobs #compneuro

4 months ago 125 91 2 0

If you calculated noise ceilings (NC) based on split-half reliability - e.g. to compare models - this one is important!
Seems many published studies miscalculated it, overestimating model performance. First, let's make this crystal clear:

NC = 2*r / (1+r)

where r is split-half correlation.

4 months ago 22 4 1 1

We recently stumbled upon a surprisingly common misunderstanding in computing noise ceilings that can be quite consequential. So if you care about noise ceilings, please check out Sander’s thread and our preprint! 👇

4 months ago 18 5 0 0

Thanks for sharing! I enjoyed this exchange. My apologies for citing your book in a suboptimal spot, that one's on us.

4 months ago 1 0 1 0
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6/ We'd like to thank all researchers who answered our questions on how noise ceilings were computed, and we thank several folks listed in the Acknowledgments for their discussions and efforts.

PDF:
osf.io/preprints/ps...

4 months ago 2 0 0 0
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5/ We also share some simulations and proofs to illustrate the core point.

Overall, our aim is to make the computation of noise ceilings more consistent across future work, and we share several tips for achieving this.

4 months ago 1 0 1 0
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4/ To this end, we offer a basic intuition with math & visuals to explain how reliability maps onto model performance. In a nutshell, split halves both contain measurement noise, but a True model does not; so the former is doubly attenuated, causing ceiling underestimation.

4 months ago 2 0 1 0
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3/ We analyzed the literature and found that about 60% of the sampled literature uses a mapping that makes models appear closer to ceiling than intended. The goal of this paper is to show the statistical underpinnings of why the above mappings follow.

4 months ago 1 0 1 0

2/ The pitfall is that although this reliability-based ceiling is expressed as a correlation coefficient, it does not reflect a ceiling on model corr (r), but on model explained var. (R²)

Specifically:
Model metric R² maps onto reliability
Model metric r maps onto sqrt(reliability)

4 months ago 0 0 1 0

1/ Noise ceilings are great because they index how much variance a model can in principle explain given noise in the data. A popular way to estimate them is by splitting the data in half, correlating these halves, and applying the Spearman-Brown correction

4 months ago 0 0 1 0
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New preprint w/ Malin Styrnal & @martinhebart.bsky.social

Have you ever computed noise ceilings to understand how well a model performs? We wrote a clarifying note on a subtle and common misapplication that can make models appear quite a lot better than they are.

osf.io/preprints/ps...

4 months ago 60 23 1 4
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Finally got the job ad—looking for 2 PhD students to start spring next year:

www.gao-unit.com/join-us/

If comp neuro, ML, and AI4Neuro is your thing, or you just nerd out over brain recordings, apply!

I'm at neurips. DM me here / on the conference app or email if you want to meet 🏖️🌮

4 months ago 81 51 1 5

Thanks for sharing these. I think causality is what lies at the core of that TICS paper. I guess separating control & mechanistic explanation is more a statement about the use of our causal models; maybe both boil down to mapping causes and effects?

4 months ago 1 0 0 0
Reply to ‘Top-down and bottom-up neuroscience as collections of practices’ - Nature Reviews Neuroscience Nature Reviews Neuroscience - Reply to ‘Top-down and bottom-up neuroscience as collections of practices’

@loopyluppi.bsky.social & @frosas.bsky.social have written a reply. I recommend reading this as it clarifies their stance and advances the discussion:
www.nature.com/articles/s41...

I think this was a fruitful exchange. It was also a great experience to write this up w/ David in Amsterdam @ CCN2025

4 months ago 2 1 1 0
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Top-down and bottom-up neuroscience as collections of practices Nature Reviews Neuroscience - Top-down and bottom-up neuroscience as collections of practices

Despite these points, we find the precision/accuracy distinction a useful one.

Finally, our piece considers what targets might be the end-point of a precision/accuracy-first approach. We distinguish mechanistic explanation, prediction, and control

PDF: rdcu.be/eSKYI

4 months ago 2 0 1 0

Third, we question the normative assumptions. Bottom-up is said to emphasize solid foundations & experimental control. We argue that these virtues are also embodied by top-down, just in a different form. And if this were not so, that would be a reason to consider approaches as not equally valid.

4 months ago 1 0 1 0

Second, the distinction doesn’t always cut cleanly. Is Kandel’s work on Aplysia really precision-first, as suggested? From another angle, it looks accuracy-first: it operationalizes memory via an ambitious linking hypothesis.

4 months ago 2 0 1 0
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Our first point: this distinction collides with other accounts in the literature. We catalogue some of the diverse meanings and practices associated with "bottom-up" and "top-down" neuroscience.

4 months ago 8 2 1 1