New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.

The Structural Basis of alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors Microtubules polymerize from cytoplasmic pools of soluble αβ-tubulin heterodimers that support diverse cellular functions. The tubulin cofactors, TBCC, TBCD, TBCE, and the Arl2 GTPase, form TBC-DEG as...

Happy to share that our new preprint from the Al-bassam lab at @ucdavis.bsky.social is out on @biorxivpreprint.bsky.social 🎉

The Structural Basis of Alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors

www.biorxiv.org/content/10.6...

Cryo-EM structures of the tubulin cofactors reveal the molecular basis of alpha/beta-tubulin biogenesis - Nature Communications Microtubules depend on correctly assembled αβ-tubulin subunits for cellular structure and transport. Here, authors reveal how tubulin cofactors form a cage-like, GTP-dependent complex that catalyzes α...

Happy to share our paper is out now in @natcomms.nature.com : “Cryo-EM structures of the tubulin cofactors reveal the molecular basis of α/β-tubulin biogenesis.” 🎉 www.nature.com/articles/s41...

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social

www.biorxiv.org/content/10.1...