Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N6-methyladenosine (m6A) at the level of individual...

Checkout our new preprint (www.biorxiv.org/content/10.1...) where we optimize Dorado on RNA from multiple cell types and directly compare to GLORI-seq.

Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing Nanopore direct RNA sequencing (DRS) coupled with Dorado modification-aware basecalling enables mapping of epitranscriptomic modifications including N6-methyladenosine (m6A) at the level of individual...

There's a lot of excitement about Dorado, the new modification-aware basecaller from Oxford Nanopore Technologies@nanoporetech.com but the accuracy and best practices are not widely understood.

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA Cingaram et al. present rPRO-seq, a rapid, low-input technique that enables nascent transcript profiling from as few as 5,000 cells. Using this method in neurons, they uncover a crucial role for INTS1...

Enhancing transcriptome mapping with rapid PRO-seq profiling of nascent RNA: Molecular Cell www.cell.com/molecular-ce...