Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...

Just published in Nat. Neurosci.

Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression.

@erzimmer.bsky.social
@natureportfolio.nature.com

www.nature.com/articles/s41...

Absolutely!

Another reason to study developmental biology for #Alzheimer disease @erzimmer.bsky.social

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

@beyoung40.bsky.social speaking about the @rushalzheimers.bsky.social Latino Core in Lima for the @alzassociation.bsky.social #AAICSatellite. Plus, she shouted out the team! @drmlamar.bsky.social and Dr. David Marquez

She’s so good!

@alzdemjournals.bsky.social

Dr. @erzimmer.bsky.social in action at the #AAICSatellite in Peru, presenting the landscape of 🩸biomarkers in Brazil. His talk highlighted key advances and outlined promising perspectives to boost Brazil’s response to dementia — from research to public health @alzassociation.bsky.social

What a spectacular event the first @embo.org #Astrocyte Workshop was!

An inspiring kickoff to the #EMBOastrocytes workshop honoring the legacy of #ElenaGalea

The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.

We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...

Please share with your circles!

Welcome! 🧠🌟🧠

Day 3 of Neuroscience
Next 2025 - Buenos Aires Hub 🇦🇷

#neuroscience #AAlCNeuroscienceNext #fleni #alzheimer
#alzheimersassociation #dementia
#neuropsychology #ENDALZ #argentina
#buenosaires #aging @erzimmer.bsky.social @luciacrivelli.bsky.social @alzassociation.bsky.social @nvillain-alz.bsky.social

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

I hope you haven’t missed this awesome new study by
@caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰

Congratulations! Reading list! ☺️

Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...

So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳
Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI

www.nature.com/articles/s41...

#AAICNeuro Cameroon Hub: Day Two!

Kickoff of #AAICNeuro in Porto Alegre! 🌎 This week, 12 hubs worldwide will showcase the next generation of Alzheimer’s & dementia researchers and clinicians.

Stay tuned for updates throughout the day!

@alzassociation.bsky.social @erzimmer.bsky.social #CristianoAguzzoli

#AAICneuro POA Hub just started in our beloved Porto Alegre 🇧🇷! A great pleasure to co-host the event with #CristianoAguzzoli @zimmerneurolab.bsky.social @alzassociation.bsky.social

A man was destined for early Alzheimer’s — these genes might explain his escape Scientists identify nine genetic variants that could have helped a man to avoid dementia for at least two decades longer than expected.

Despite carrying a genetic mutation associated with early-onset #Alzheimer’s, a man remained free of dementia symptoms for at least 2 decades longer than expected 👉 genetic variants may explain this remarkable resilience. See more here: www.nature.com/articles/d41...

Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.

Important work by #JorgeLibre-Guerra and team on @naturemedicine.bsky.social about genetic resilience to early onset #alzheimers👇

www.nature.com/articles/s41...

@stforner.bsky.social presenting the @alzassociation.bsky.social global funding programs at #FloripaNeuro 🇧🇷

Incredibly happy to share this co-first publication in the Lancet Global Health with #DaRos and #Aguzzoli guided by the brilliant @erzimmer.bsky.social

If you are a scientist in the Global South 👇👇👇👇

100%! Will add you!

The words "Hello, Bluesky!" with the Bluesky butterfly logo below. They are white against a purple background.

Hello, #Bluesky! With so many voices making their way to this new community, we are excited to enter the conversation.

#ENDALZ

The ISTAART Ambassador Program: Your Passport to a Global Dementia Research Community YouTube video by Paige Logan

The ISTAART Ambassador Program is still open for applications!

Hear what the current cohort has to say about the program, what it meant to them, and why you should apply!

www.youtube.com/watch?v=Y_7-...

'Origins of food selectivity in human visual cortex'

by Margaret Henderson, Michael Tarr & Leila Wehbe

www.cell.com/trends/neuro...

In 🇧🇷, and probably in most countries with high levels of disparities and inequalities, education is one the most important risk factors for cognitive decline! Amazing work by #LucasdaRos @vbwyll.bsky.social #CristianoAguzzoli and team @thelancet.bsky.social

Check out our group's new study highlighting the importance of understanding the population in the Global South! 👇 Congrats #LucasdaRos @vbwyll.bsky.social @erzimmer.bsky.social

Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries Our findings indicate that Brazil converges with other Latin American countries to show that heterogeneous factors impacted more than demographic factors, but also showed a unique set of health factor...

New Study just out in The Lancet Global Health! #LucasDaRos, @vbwyll.bsky.social, #CristianoAguzzoli & colleagues used a machine learning model to determine the most important risk factors for cognitive and functional decline in Brazil and other LATAM Countries 🧵 www.thelancet.com/journals/lan...

Pain-Related Memory Impairment: How does chronic pain lead to memory loss? A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.

Our comment on a very interesting @elife.bsky.social
paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out!
elifesciences.org/articles/105...