Added to
bsky.app/starter-pack...

@elixircz.bsky.social added

@imgprague.bsky.social added

@sciencecharles.bsky.social added

We would also like to thank our collaborators from Faculty of Medicine and Dentristry Palacky University Olomouc and CATRIN UPOL

pomegranate rind

Resistance in both can be overcome>
- pomegranate rind extract, which inhibits both flagellin and biofilm production,
or
- by covalently binding #AgNP to a composite material containing graphene sheets, which protects AgNP aggregation.

Bacterial resistance to silver nanoparticles and how to overcome it - Nature Nanotechnology Gram-negative bacteria exposed to subinhibitory concentrations of silver nanoparticles can develop resistance to their antibiotic activity due to the production of flagellin, an adhesive protein of th...

G- E.coli produces flagellin (basically to whip AgNPs to precipitate. (similarly as in our
@naturenano.bsky.social
paper nature.com/articles/s41... )

G+ S.aureus form biofilm around AgNPs to incapacitate its antibacterial properties.

Antibacterial resistance to silver nanoparticles is the same for both types of bacteria - aggregation of AgNP to form black precipitates.

However, the way in which Gram-positive and Gram-negative bacteria induce aggregation of silver nanoparticles is completely different.

E. coli and S. aureus resist silver nanoparticles via an identical mechanism, but through different pathways - Communications Biology Bacteria resist AgNPs by aggregating them through the flagellin production in E. coli or biofilm formation in S. aureus. Protection from AgNPs aggregation by pomegranate rind extract or strong Ag bind...

Link to the article:
www.nature.com/articles/s42...

Cover image in @CommsBiol about our Featured article on the development and overcoming of bacterial resistance to AgNP. The mechanism of resistance is the same for both types of bacteria and involves the aggregation of silver nanoparticles leading to the formation of black precipitates. However, the way in which Gram-positive and Gram-negative bacteria induce aggregation of silver nanoparticles is completely different. Chemical analysis of the surface of the silver precipitates shows that aggregation is triggered by flagellin production in E. coli and by bacterial biofilm formation in S. aureus. However, resistance in both types of bacteria can be overcome by using pomegranate rind extract, which inhibits both flagellin and biofilm production, or by stabilizing the silver nanoparticles by covalently binding them to a composite material containing graphene sheets, which protects the silver nanoparticles from aggregation induced by the bacterial biofilm produced by S. aureus.

Our colleagues Aleš Panáček and Lucie Hochvaldová published a Featured article in @natureportfolio.bsky.social
journal @commsbio.bsky.social describing how bacteria resist AgNPs by aggregating them through the flagellin production in E. coli or biofilm formation in S. aureus and how to overcome it

All three added> @bacdive.bsky.social @brenda-enzymes.bsky.social @lpsn.bsky.social

added

@uclchemistry.bsky.social added

we added @chemrxiv.bsky.social

Here is a shortlist of chemical news and journals we have found so far. Please, let us know if tou know about some other. go.bsky.app/CAYUJ5B

Are there any other accounts for Chem&Biol Data? go.bsky.app/RvEm6Bh

already in data starting pack

Is there any other Chem&Biol department or institute for this starter pack?
go.bsky.app/7fkRhAy

At the end of January we organize hybrid 8th Advanced in silico drug design workshop -
registration is open both onsite and online
www.kfc.upol.cz/8add #chemsky #compchemsky #biosky 🧪💊🧬🖥️