Sometimes DNA replication hits a 🛑 roadblock.
Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact.

That’s the focus of our new review in @cp-trendsbiochem.bsky.social:
“Just bypass it: mechanisms of DNA damage tolerance”

🔗 doi.org/10.1016/j.ti...

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

Spend a week in Ventura for this year's GRC & GRS Mammalian DNA repair. Very stimulating meeting with great science and new relations! Followed by roadtripping through California's beautiful national parks. Now, relaxed and ready for the bench again

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL

Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Computational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Do you want to be part of a state-of-the-art core facilit

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community:
candidate.hr-manager.net/ApplicationI...