Proposed algorithm for the application of rituximab in minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) ca. 2020
#Nephpearls #NephSky
👉 pubmed.ncbi.nlm.nih.gov/32942039/
It will not be approved outside the US - plus, BAFF/APRIL are more reasonable for patients
Irrelevant drug for 7.95 billion people globally (in this indication)
No, I do not target this! Of course you want serologic remission, but it is not always achievable (and has no major clinical relevance)
I am fan of 6-monthly but only one dose
Yes, would do so; we are starting using it - Allegory data now really show the power of obi
Rare Kidney Diseases
'Rare Kidney Diseases' is a peer-reviewed, #OpenAccess journal dedicated to advancing clinical and translational knowledge in glomerular, autoimmune, and genetic kidney diseases across all age groups. bit.ly/3ZG9FA5 @glomcon.org #NephSky @kronbichlerlab.bsky.social
Images in Clinical Medicine Periumbilical Erythema Migrans Panel A: A photo of the periumbilical erythema and a small gray protrusion in the umbilicus. Panels B and C: Photos of a tick being extracted from the umbilicus.
An 80-year-old man presented with a 4-day history of a rash on his abdomen. Physical examination was notable for periumbilical erythema and a small gray protrusion in the umbilicus. Read the full case details: nej.md/4pYF5NO
@i-med.ac.at #MedSky #DermSky
Had a super weird case here once, but agree very unlikely! But she was PR3 sky high
IgG4?
Interesting case, indeed. PR3 in the context of C3G rather uncommon. Undetectable C3 would prompt alternative pathway investigations; also in the consideration cryoglobulins and cryofibrinogen, although C4 reduction would be more common
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
Pretty much everything was even surprising to us!
Please also look at the Supplements for all the unique features of the case 😉
Extrarenal “crescent” in multisystem granulomatosis with polyangiitis
doi.org/10.1016/j.kint.2025.03.028
🔹Paravertebral masses in systemic vasculitides such as GPA are rare
🔹This pt had a rupture of the A. colica dextra leading to GI bleeding
#MedSky #NephSky @i-med.ac.at @kronbichlerlab.bsky.social
Absolute rarity; only once when the patient was double-positive and the MPO-ANCA became dominant!
Most will eventually turn anti-GBM antibody negative when established on dialysis! Otherwise, you might consider a dose of rituximab
If kidney is lost and no extrarenal manifestation, there would be no indication to use RTX or CYC, right?
The International Vasculitis Workshop is coming up! One of my favorite meetings for it's sense of community, and possibilities of forming meaningful collaborations (PEXIVAS was hatched in one of them). Call for early career scientists is here
mailchi.mp/icmsaust/ivw...
Figure 3 Association of adherence to CONSORT 2010 statement checklist and trial size. Adherence was positively correlated with number of patients enrolled in the trial.
As the quantity of RCTs in nephrology goes up, how is the quality shaping up?
CONSORT Reporting standards, ANCA vasculitis edition from @abruch.bsky.social @kronbichlerlab.bsky.social et al in @kireports.bsky.social
www.kireports.org/article/S246...
It was a pleasure to collaborate with @kronbichlerlab.bsky.social and Dr. Astrid Weins on this article. We describe transformations in our understanding of podocytopathies, and novel treatment approaches in light of those advancements. journals.lww.com/co-nephrolhy...
I was also there and enjoyed the discussions a lot!
Secondary #TMA represent a major unmet medical need.
Grateful for the opportunity to review the role of #complement and discuss when to consider complement inhibitors in these dramatic diseases.
🙏 to outstanding co-authors and the #ERA IWG
@kronbichlerlab.bsky.social
@ndt-era.bsky.social
Understanding the role of anticoagulation in nephrotic syndrome: Please complete this survey - qualtricsxm564785h8t.qualtrics.com/jfe/form/SV_...
It takes 5 minutes and is highly appreciated. 10 more responses are needed
Don’t forget our podocytopathy study 🤣
Congratulations @johannmorelle.bsky.social and team!
Disease-modifying anti-nephropathic drugs (DMANDs) –
a definition proposed by the Immunonephrology Working Group (IWG) of the European Renal Association (ERA)
doi.org/10.1093/ndt/...
👏👏👏 @kronbichlerlab.bsky.social
#FSGS #Nephroticsyndrome #APOL1
just one small note on %FPE/genetics. The concept that genetic forms have ⬇️FPE is confounded. Most FSGS related to slit-diaphragm genes presenting with NS have ⬆️FPE. We see nearly total FPE with TRPC6, INF2, NPHS1, NPHS2, MYO1E et al
