OK #SkyBrain Hotel to stay at in Manhattan for family with teenage kids? preferably with nice breakfast (not necessarily buffet-style). Probably SoHo, NoHo East Village, Greenwich Village, Chelsea, Midtown S.

New from the #Transfusion Evidence Round-Up: Best of the TEL 2024:

Two-year outcomes following a randomised platelet transfusion trial in preterm infants
by Moore et al.
www.transfusionevidencelibrary.com/alerts/artic...

99% of the circulating cells, 84% of the cells in the body are RBCs. These 25 trillion cells shed 1 vesicle/h (more under stress). With >250 transporters and receptors, RBCs pick up/release metabolites, at times even against gradient, throughout the body. Yet, they are not part of 👇 conversation

We are switching to a threshold of 9 (5.6) for the first month after the insult. #TRAIN #HEMOTION #SAHARA #TMSky

Great job! Can’t help noticing the similarities to the #Hemotion trial in #TBI - non-significant results suggesting pos. effect of lib. transf. - confirmed later in #TRAIN. Could results be pooled together? Same mechanisms? #TMSky #HemeSky

Thanks for posting! who are the authors?

International Consensus Statement on Platelet Function and Genetic Testing in Percutaneous Coronary Intervention: 2024 Update Current evidence indicates that dual antiplatelet therapy with aspirin plus a P2Y12 inhibitor is essential for the prevention of thrombotic events aft…

Recommandation in favor of using platelet function testing for tailoring anti-platelet therapy in coronary disease… #HemeSky #TMSky

www.sciencedirect.com/science/arti...

Nothing on preoperative anemia 😳

Thromboelastography or rotational thromboelastometry guided algorithms in bleeding patients: An updated systematic review with meta‐analysis and trial sequential analysis Background Bleeding patients face significant morbidity and mortality due to impaired haemostasis. Haemostatic resuscitation has evolved, yet the optimal approach remains unclear. The primary object...

Benefits of VHA in bleeding patients - less transfusion, less reintervention, less bleeding - and lower mortality ? (RR 0.76, 95% CI 0.57–1.00). #TMSky #HemeSky
onlinelibrary.wiley.com/doi/10.1111/...

Nice!

www.thieme-connect.com/products/ejo...?

🩸Platelets!

Lifespan 7-10 days
150-450 × 10⁹/L
Stimulated by TPO
1/3 sequestered in spleen

Receptors:
GpIIbIIIa -> fibrinogen
GPIb-IX-V -> vWF
P2Y12 -> ADP

Granules:
Alpha = fibrinogen, vWF, V, VEGF, PF4, PDGF, P-selectin
Dense = ADP, Ca, Serotonin
#hemesky #MedSky

van der Meijden et al, 2019

Two fab threads on Andexanet-Alfa summing up published data and FDA data. I agree that Andexanet is NOT the holy grail of anti-anti-Xa! #MedSky #TMSky #HemeSky

Nye tal viser, at sygehusene ikke har fjernet ventetidspuklen for en stor gruppe af plagede patienter: »Det er skandaløst, at patienters rettigheder ikke tages mere alvorligt« Behandlingsgarantien er »et spil for galleriet«, der har meget negative konsekvenser for patienterne, mener sundhedsprofessor.

Så er det juletid i Folketinget og politikerne deler pakker og garantier ud til de raske. Men ‘Når du strammer garnet, kvæler du jo barnet’.
Hvis alle sygdomme skulle behandles inden 30 dage så blev ingen behandlet inden 30 dage.#dksund #dksund jyllands-posten.dk/indland/ECE1...

Be aware that this is not exclusively trauma, but also spontaneous SAH and ICH.
Seem to avoid some of the secondary ischemic injuries after hemorrhage.
In accordance with #hemotion

Pilot study comparing daily to alternate days and thrice weekly oral iron in pregnant women.
- Interestingly, thrice weekly seems unfavorable mainly due to peripartum outcomes… #TMsky #Hemesky

ashpublications.org/bloodadvance...

There is a reason for not recommending #andexxanetalfa for #DOAC reversal - we simply do not know enough…! #TMSky #HemeSky

In summary:
1. Phlebotomy = 30-50 ml/day blood loss
2. This worsens anemia and increases costs/transfusion
3. Simple strategies can be taken, including drawing fewer labs, using smaller volume tubes, using closed loop sampling, and using non-invasive technologies.

#anemia #medsky #ansky #emimcc

Management of human leukocyte antigen‐mediated platelet transfusion refractoriness: Brief synopsis and recent literature review Click on the article title to read more.

Brief review on options for immune platelet refractoriness… interesting that using a MFI cut-off of 10.000 still yields works in immune-refractory patients w/ HLA-Abs, might change our guidelines. #hemesky #tmsky

onlinelibrary.wiley.com/doi/abs/10.1...

thx

Same…