New preprint: Psychological stress and social support are associated with opposing single-cell pro-inflammatory gene regulatory mechanisms in adults w/ @rogerpique.bsky.social

In #GENETICS, @fluca2406.bsky.social @rogerpique.bsky.social @ripplesintime24.bsky.social & team find inflammation & cardiovascular disease genes risk are associated with poverty. Read this association study showing how social factors influence health outcomes & life expectancy: buff.ly/OaUpKrs

In the July issue of #GENETICS, @fluca2406.bsky.social, @rogerpique.bsky.social, @ripplesintime24.bsky.social highlight how social factors influence health outcomes & life expectancy by showing an association between inflammation and cardiovascular disease risk genes & poverty: buff.ly/uE3R3FE

Happy to share the published version of Omar & Sayan’s paper. We generated a DNA-damage-associated cardiomyocyte protein co-expression network to gain insights into tolerance to genetic variation and disease. www.sciencedirect.com/science/arti...

Disease-associated loci share properties with response eQTLs under common environmental exposures Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To un...

www.biorxiv.org/content/10.1...

Bacterial infection remodels the DNA methylation landscape of human dendritic cells - PubMed DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendritic cel...

We also first used different fragment bins with ATAC and Centipede: pubmed.ncbi.nlm.nih.gov/26392366/
In the supplement. "...run Centipede the aligned paired-end reads were separated into four bins depending on the fragment length ([40, 99], [100, 139], [140, 179] and [180, 250] in bp). "

"Y-axis represents the point projection perspective from the observer to the vanishing point and that is orthogonal to the horizon line" ?