How We Should Target Aging | Peter Fedichev YouTube video by The Sheekey Science Show

How We Should Target Aging | Peter Fedichev

www.youtube.com/watch?v=buEP...

Gene therapy safely eradicates brain tumours in mice A single dose of an innovative gene therapy could eliminate hard-to-treat brain tumours and prevent them from coming back. The innovative treatment is built on research led by Professor Steve Pollard ...

GENE THERAPY SAFELY ERADICATES BRAIN TUMOURS IN MICE

A single dose of an innovative gene therapy could eliminate hard-to-treat brain tumours and prevent them from coming back, according to a pre-clinical trial in mice, reported in Nature.

edinburgh-innovations.ed.ac.uk/news/trogeni...

'Dead End': Radical 20-Year Study Reveals Genetic Cloning Hits a Limit Scientists have pushed the limits of mammal cloning until the whole house of cards has come tumbling down.

Dead End': Radical 20-Year Study Reveals Genetic Cloning Hits a Limit

www.sciencealert.com/dead-end-rad...

Geroscience’s Guiding Star: Extending Healthy Lifespan In a landmark editorial published on March 10, 2026, in Volume 18 of Aging-US, David A. Barzilai, a prominent figure affiliated with Geneva College of Longevity Science, Healthspan Coaching LLC, and

Geroscience’s Guiding Star: Extending Healthy Lifespan

🌟"Barzilai makes a clarion call for a “moonshot”-level investment in aging biology... This ambitious commitment aims to accelerate the field’s capacity [to] extend both lifespan and healthspan" worldwide. 🌍

🚀 bioengineer.org/gerosciences...

The future of geroscience should not be framed as a choice between lifespan and healthspan. In my new editorial, “Healthy life extension: Geroscience’s north star,” I argue that this is the wrong… | ... The future of geroscience should not be framed as a choice between lifespan and healthspan. In my new editorial, “Healthy life extension: Geroscience’s north star,” I argue that this is the wrong deb...

Patients are asking for time with family, time in full cognition, time in independence, and time living on their own terms.

That is why geroscience should be judged not only by survival, but by whether it extends life by extending health.

My Editorial:

www.linkedin.com/posts/agingd...

My Editorial 🩺

"...stop treating “lifespan vs. healthspan” as a fork in the road. In medicine, and in the lives our patients actually live, they are not competitors. The only mission that is both scientifically coherent and clinically meaningful is healthy life extension: more years in full health"

Gut microbes affect cognition during ageing As mice age, changes in the microorganisms in their guts contribute to cognitive decline by altering signalling between the gut and brain.

Gut microbes affect cognition during ageing

As mice age, changes in the microorganisms in their guts contribute to cognitive decline by altering signalling between the gut and brain.

www.nature.com/articles/d41...

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice This study shows that oxidative changes in oocytes from aged female mice lead to lipid droplet accumulation and altered energy and retinoid metabolism. These changes persist in embryonic organs, trig....

Intergenerational Transmission of Metabolic Changes in Oocytes From Aged Mice

onlinelibrary.wiley.com/doi/10.1111/...

Frontiers | Impact of exercise-induced DNA damage repair on age-related muscle weakness and sarcopenia Sarcopenia, the progressive and generalized loss of skeletal muscle mass, strength, and function with aging, poses a significant public health challenge. A k...

Impact of exercise-induced DNA damage repair on age-related muscle weakness and sarcopenia

👉 “exercise-induced enhancement of DNA repair [contributes to] maintaining mitochondrial health, preserving muscle stem cell function, and combating cellular senescence”

www.frontiersin.org/journals/gen...

Bridging Ethics, Science, and Practical Longevity YouTube video by Longevity.Technology

Is #geroscience and #longevity for everyone, or just for a few? Podcast on the ethics of it all, with @agingdoc.bsky.social and Carolyn Ringel: www.youtube.com/watch?v=Tedu...

Boston's Longevity Obsession: What Works and What Doesn't We talked to doctors at Mass General, Brigham and Women's, and more.

Boston’s Longevity Obsession: What Works and What’s Expensive BS

We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...

How to Make Friends as an Adult

How to Make Friends as an Adult

A practical guide for expanding your circle, with advice from sociable people.

www.nytimes.com/article/how-... @nytstyle.bsky.social

Glucagon-like peptide-1 medicines and cancer - Nature Cancer Yabut and Drucker discuss clinical and preclinical evidence about the potential roles of GLP-1 medicines on cancer incidence, development and therapy and speculate about their mechanism on cancer cell...

Glucagon-like peptide-1 medicines and cancer

www.nature.com/articles/s43...

Senate advances bills rejecting Trump’s efforts to slash research funding The White House sought cuts of 40% or more at some agencies, but lawmakers from both parties are pushing to hold science spending relatively steady.

Senate advances bills rejecting Trump’s efforts to slash research funding 🧪

The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.

www.highereddive.com/news/senate-...

Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds Gamma irradiation, an industry-standard sterilization method for medicinal and recreational cannabis, does not fully eliminate toxic fungi or their chemical residues, a McGill University study has fou...

Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds

Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards

www.mcgill.ca/newsroom/cha...

Targeted delivery of genome editors in vivo

🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺

www.nature.com/articles/s41...

👍⚕️

My friend Andrew Steele is building this:

The majority of poor health and deaths globally are caused by diseases that become common with age...

"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded

We exist to change that" 🧑‍⚕️⚕️

thelongevityinitiative.org

This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”

💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻‍⚕️

t.co/hMdyfVk58W

Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity

👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.

academic.oup.com/jcem/article...

People often ask me the same question:

“What’s the single most promising anti-aging measure coming in the next decade?”

If you care about where longevity medicine is truly heading, this one’s worth a look.

🔗https://www.instagram.com/reel/DRni2qQgNTS

Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM on X: "Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric" / X Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric

Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function

"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"

x.com/agingdoc1/st...

My post from Founders Forum North America (NYC) 🗽

🔗 www.linkedin.com/posts/agingd... 🚀

AI Learns to Design the Human Body’s Most Elusive Proteins - Neuroscience News A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human pro...

AI Learns to Design the Human Body’s Most Elusive Proteins

🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.

neurosciencenews.com/ai-protein-d...

Human skin DNA fertilised to make embryo for first time US scientists testing the technique say it could help people overcome infertility and potentially allow same-sex couples to have a genetically related child.

Scientists make embryos from human skin DNA for first time

www.bbc.com/news/article...

This AI tool predicts your risk of 1,000 diseases — by looking at your medical records

Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat

nature.com/articles/d41...

@shamini.bsky.social 🧪

Sex-specific longitudinal reversal of aging in old frail mice | Aging Aging | doi:10.18632/aging.206304. Cameron Kato, Jessica Zheng, Cindy Quang, Sophia Siopack, Joana Cruz, Zachery R. Robinson, Nicole Fong, Zhixin A. Zhang, Patrick Young, Michael J. Conboy, Irina M. C...

Sex-specific longitudinal reversal of aging in old frail mice

www.aging-us.com/article/2063...

The evolution of cancer and ageing: a history of constraint - Nature Reviews Cancer In this Perspective, de Magalhães explores the evolutionary relationship between cancer and ageing, proposing that the need to minimize cancer risk early in life may contribute to tissue degeneration ...

The evolution of cancer and ageing: a history of constraint

www.nature.com/articles/s41...

@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.

Some source for optimism: for some animal models, better healthspan can track increased longevity.

pmc.ncbi.nlm.nih.gov/articles/PMC...

We’re thrilled to welcome David Barzilai MD PhD MBA MS DipABLM—an internationally acclaimed expert in longevity, CEO of Healthspan Coaching LLC, and a founding faculty member and Trustee of the… | Rev... We’re thrilled to welcome David Barzilai MD PhD MBA MS DipABLM—an internationally acclaimed expert in longevity, CEO of Healthspan Coaching LLC, and a founding faculty member and Trustee of the Geneva...

www.linkedin.com/feed/update/...