Capturing dynamic phage–pathogen coevolution by clinical surveillance
"we capture the acquisition of a parasitic anti-phage mobile genetic element, PLE11, that initiated a selective sweep coinciding with the largest cholera outbreak in recent records. "
www.nature.com/articles/s41...
Excited to share our latest work! 📝
We measured the fitness effect of 136 AMR genes and found that many are neutral or even beneficial without selection. 🤯🧬
Oxygen availability can flip their fitness and our stochastic model indicates that oxygen fluctuations help maintain them.
Learn more 👇🏼
What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔
New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE).
www.nature.com/articles/s41...
Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity.
💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks.
www.biorxiv.org/content/10.6...
New paper out in @pnas.org, and it made the cover! 👁️
We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve.
‼️Check Paula’s 🧵 and the paper👇
𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿
www.pnas.org/doi/10.1073/...
We’re excited to kick off a new season of the Klebsiella Seminar Series, held on Thursdays in April 🧫🧬!
We have 3 sessions on pathogenesis, pediatric Klebsiella & translational approaches. We will also have an open session.
Registration is mandatory & FREE in this link
forms.gle/LhJu11WQN6Yy...
🔁
Last project of my PhD is out as a preprint!