A Distinct Layer 1 Astrocyte Program Shapes Perisynaptic Structure and Calcium Signaling in Mouse Motor Cortex www.biorxiv.org/content/10.64898/2026.03...

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/

🚨🚨🚨NEW PAPER ALERT🚨🚨🚨

We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...

check out the @okaysteve.bsky.social lab’s posters (for both neuron and glia enthusiasts) at #SfN2025 on Saturday PM! especially say hello to @siriacoello.bsky.social who is applying to grad school this cycle✨

thanks so much for hosting me, looking forward to sharing my work! 

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain Injury www.biorxiv.org/content/10.1101/2025.09....

90% of neuroscience papers are one of:
1. it turns out what we thought was generally true was actually just a special case
2. the thing we think is true contains smaller things that we can measure
3. what we thought was true is still true, but now with lasers pew pew

This is why science funding matters.

We uncovered a hidden signaling system in the brain—one that responds to maternal environment, even to drugs like LSD during pregnancy.

It took 5 years, a brilliant team, and public funding to get here.

Out today in @NatureNeuro: 🧵👇

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

Flyer for Massachusetts stand up for science, at the Massachusetts state capitol in Boston on March 7th from 12-4 PM. More info at standupforscience2025.org

HEY BOSTON! 📣☀️

MARCH 7TH, MASSACHUSETTS STATE CAPITOL!

Join us to #standupforscience2025 and make your voice heard!

SEE YOU THERE!

www.standupforscience2025.org #standupforscience20225

Shared some of my recent experiences and thoughts with @callimcflurry.bsky.social of @thetransmitter.bsky.social. In these chaotic times, it’s important that there’s an ability for voices to be heard. I’m very thankful to Calli and The Transmitter for the opportunity.

if you listen closely, you can hear the sound of every scientist in the US screaming

so sorry, what a good pup 🥲

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...

Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review.
Colossal work by the team and driven home by @mathiasgua.bsky.social
Quick 🧵 of what's new -
www.biorxiv.org/content/10.1...