Excited to share our preprint using Rhizobium rhizogenes AS109 for agroinfiltration, facilitating strong transient expression across non-model plants including sweet potato, mustard, Medicago and faba bean!

doi.org/10.64898/202...

1/7

Big news for correlative cryogenic SMLM/ET! With my colleague Soheil, we (Mahamid and @jonasries.bsky.social labs) indicate lamella-specific illumination can allow 500-1500x higher laser intensities, opening massive new possibilities for correlative imaging #teamtomo

www.biorxiv.org/content/10.6...

Oocytes store large amounts of proteins to support the earliest developmental stages. In @nature.com, the Leung group describes the structure of the cytoplasmic lattice in unprecedented detail. At least 13 different proteins assemble into a stable storage complex. hubrecht.eu/oocyte-storage-complex/

Mann in einem weißen Kittel vor einem Whiteboard

Der Biologe Dr. Florian Altegoer vom Institut für Mikrobiologie der Heinrich-Heine-Universität Düsseldorf (HHU) erhält einen mit 210.000 Euro dotierten „Exploration Grant“ der Boehringer Ingelheim Stiftung (BIS).

New preprint 🚀 ❄️
We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows

✔️ improved grid stability
✔️ reduced handling
✔️ robust vitrification (🦠 🧫 🧠)
A step toward routine HPF for complex samples
#teamtomo

Another day another beautiful inflammasome structure! "Structure of zebrafish NLRP3 reveals a novel mode of inflammasome activation" by Dopslaff et al.
www.biorxiv.org/content/10.6...

Excited to share our paper about copick, a dataset API and toolkit for collaborative annotation and analysis of #cryoET data! Whether you're picking particles or curating segmentations, copick reduces friction and brings #OME-Zarr to cryoET without breaking pipelines.
🧵👇

doi.org/10.1002/pro.70578

Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.

Phytophthora targets plant extracellular vesicles to promote infection a and b, TET8, TET9, PEN1, but not ARA6 could be detected in total extracellular vesicles (P100 pellet) of Arabidopsis. a, eGFP labeled proteins and plant actin were detected by western blotting. b, Confocal microscopy of EVs isolated from TET8-eGFP, TET9-eGFP, ARA6-eGFP and eGFP-PEN1 expressing Arabidopsis respectively. Bar, 10 µM. c, EVs were isolated from TET8-eGFP expressing lines. AWF (without EVs) were prepared by ultracentrifugation at 100,000 × g for 6 hours. Proteins were detected by western blotting. d, Schematic representation of purification of plant EVs by Size Exclusion Chromatography (SEC). e, Elution fractions of Size Exclusion Chromatography were collected. TET8-eGFP, TET9-eGFP and eGFP-PEN1 were detected by western blotting. Dashed box indicates collection of EV fractions for further analysis. BV (Buffer Volum). f, Transmission electron microscope (TEM) observation of EVs fraction (Elution: 0.496-0.540 ml). Bars, 200 nm. g, Nanoparticle tracking analysis (NTA) of EVs fraction (Elution: 0.496-0.540 ml) was collected. Graph shows distribution of particle size intensity. h, SEC-EV particle number corresponding to different protein concentrations. EV abundance was quantified by NTA, with particle count representing EV quantity. i, TEM observation of soybean EVs (Size Exclusion Chromatography purification, same fractions with Arabidopsis EVs). EVs from soybean leaves were isolated. j...

Phytophthora targets plant extracellular vesicles to promote infection
->Nature | More on "Plant pathogen extracellular vesicle infection" at BigEarthData.ai | #Infection

Emmanuelle Bayer

👏So well deserved silver medal from @cnrs.fr 😍

Emmanuelle Bayer @emmanuellebayer.bsky.social from @lbmcinlyon.bsky.social is an outstanding scientist 🤓 and one of a few female role model in the plant research field 🍀

www.insb.cnrs.fr/fr/personne/...

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

The exocyst higher-order structure (ExHOS) in yeast exocytosis Constitutive exocytosis is the cellular pathway that transports secretory vesicles (orange) to the plasma membrane (green) uninterruptedly, an essential proc...

Meet ExHOS: a flexible protein ring that assembles, pulls vesicles into place, then disassembles for the next round.
A new look at how cells control exocytosis, by HFSP Research Grant Awardees! 🧪
Read more 👉 zurl.co/sXDka
#sts

zurl.co/n0LO9

Its strangely apropriate to name this after somone famous for having her data stolen and not being given credit

Check out our story online now in Science!

ERC penalize the applicants to reduce the number of applications while increasing the years post PhD to increase the number of applicants.

There is nobody behind the wheel...

Applying for an ERC grant in the 2027 competitions: what you need to know The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...

I don’t know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...

Fluorescent Anabaena. Fluorescently labelled CorM filaments inside Anabaena. These represent a newly discovered cytoskeleton in multicellular cyanobacteria. © Loose group

Photosynthetic bacteria helped shape Planet Earth. Among them cyanobacteria—microbes that produced the oxygen in Earth’s atmosphere & made complex life possible. They have captivated scientists for decades by offering insights into how life evolved from single cells into multicellular organisms.

Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social

👉 rb.gy/lnrizk

special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM

Are the days of discovering new cellular structures over?? /1

Genome–host association mapping reveals wheat pathogen genes involved in host specialization - Nature Plants This study introduces genome–host association (GHA), leveraging natural epidemics to map the genetic landscape of host adaptation in the pathogen Zymoseptoria tritici. Applied to 832 wheat fungal stra...

Thrilled to share our paper now out in Nature Plants 🎉
We developed a genome-host association (GHA) approach to study pathogen adaptation directly from field metadata by using the originating host cultivar as phenotype.

www.nature.com/articles/s41...

We could also say that two @zmbp-tuebingen.bsky.social junior PIs and three @greenrobust.de PIs won the 2018, 2026 and 2027 @biochemsoc.bsky.social
awards 😉 We are good at recruiting biochemists! 😄

@thesainsburylab.bsky.social is on a roll! Awards from 2025, 2026 and 2027 went to current or former TSL members! @tatsuyanobori.bsky.social, myself and @mpcontreras.bsky.social
And also @plantophagy.bsky.social in 2018 🤯

TSL Alumnus wins Biochemical Society Award Mauricio Contreras has been recognised as an exceptional Early Career Researcher by the Biochemical Society. Currently based at the University of Tübingen, Germany, Mauricio previously spent several…

We are happy to celebrate @mpcontreras.bsky.social winning the @biochemsoc.bsky.social 2027 Early Career Research Award!

Mauricio joined TSL as a predoc with @kamounlab.bsky.social, where he did PhD and postdoc before starting his group at @zmbp-tuebingen.bsky.social

Congrats Mau!

Undaria pinnatifida gametophyte

Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...

Portrait of Dr Laura Lorenzo-Orts, Institute of Molecular Biology, Germany, recipient of the 2027 Biochemical Society Early Career Research Award.

Bridging the gap between biochemistry and developmental biology, we are excited to announce Laura Lorenzo Orts as a recipient of an Early Career Research Award in 2027! Laura's new lab focusses on understanding the mechanisms that activate mRNAs during early development.

Award announcement for Dr. Mauricio P. Contreras from University of Tübingen, Germany, receiving the Early Career Research Award at The Biochemical Society 2027 Awards.

As an emerging leader in plant innate immunity, we're thrilled to present Mauricio Contreras with a 2027 Early Career Research Award! Alongside advocating for Open Science and preprint review, Mauricio's "activation-and-release" and "NLR resurrection" models are already referenced worldwide.

How do “LEGO-like” electron-bifurcating modules combine to drive degradation in BTEX-contaminated ecosystems?

Check out our latest preprint, where we use cryo-EM and cryo-ET to reveal how the 1 MDa BCRII complex powers extremely endergonic aromatic ring reduction.
www.biorxiv.org/content/10.6...

The Biochemical Society announces the 2027 award winners with a gold and navy themed graphic. We're announcing our 2027 Award winners! Stay tuned for more details

Stay tuned to our feed today as we announce our 2027 Award winners, celebrating fifteen excellent bioscientists, educators and technicians working in the life sciences! #BiochemAwards

🤩🤩

Preprint alert 🚨 (1/10) 🧵

𝘈𝘶𝘵𝘰𝘱𝘩𝘢𝘨𝘺 𝘪𝘴 𝘢 𝘱𝘢𝘳𝘢𝘥𝘰𝘹 𝘪𝘯 𝘱𝘭𝘢𝘯𝘵 𝘪𝘮𝘮𝘶𝘯𝘪𝘵𝘺:
It can promote resistance, susceptibility, or restrict cell death 🤯

So what is its actual role?

We show it acts as a spatial organizer of immunity across cell types 🌱🦠 #proteostasis

www.biorxiv.org/content/10.6...