Carbon-Atom Scavengers Enable Divergent, Selective Carbon Deletion of Azaarenes Divergent synthesis is a powerful strategy that provides simultaneous access to multiple derivatives of a given substrate. However, the emerging developments in skeletal editing have largely delivered...

Our latest is a serendipitously discovered pair of reactions that can pull either the C2 or C3 carbon out of quinolines by choice of an amine scavenger. A deep mechanistic dive took us some surprising places, in @chemiejisoo.bsky.social's latest.

pubs.acs.org/doi/full/10....

Social sanctions are powerful, for ill and for good, and I personally feel like it would be good to make shit like ChatGPT utterly socially unacceptable, like the height of shame to admit using, a subject that slams down an awkward silence when it’s uncritically invoked

1,2-Acyl transposition through photochemical skeletal rearrangement of 2,3-dihydrobenzofurans Saturated heterocycles are commonly adorned with groups that influence their biological properties. Synthetic methods that transpose existing substituents on saturated heterocycles to multiple peripheral positions are therefore highly valuable. In this ...

Congratulations to Ryan and Moto on the publication of their 1,2-acyl transposition in 2,3-dihdyrobenzofurans in @science.org!

www.science.org/doi/10.1126/...

To the delight of many of my peers (alum and current students), Ono did resign (moving to Florida). DEI at UM is what made it a great place to be and seeing him bend the knee was disappointing.

okay well i guess i don’t need to read literature tn

first day in industry ✅

can’t believe i’m a process chemist

officially a bostonian (or whatever they call people who live in cambridge!)

aside from the sweet process gig, i’m now closer to one of my favorite cats in the world, stella 🫶🏼♥️

god bless canada and hockey

oh-

Capybara NMR tube holder (3x, 12x) by Serge Nader | Download free STL model | Printables.com Requested by a grad student inspired by the Romero Lab at UCSD. | Download free 3D printable STL models

☺️🧲 www.printables.com/model/557025...

you are officially my favorite person 😭♥️🫶🏼

I remember my mentor had a capybara NMR holder, i wanted one so badly 😭

excited to announce that i’ll be joining the process/hte team at vertex (boston) at the end of april!

crazy to think 4 years ago on this very day, i got into umich, now i get to transition to my dream role in industry 🤠♥️

Chemists create matchmaking app for biocatalysis Machine learning model Catnip helps chemists find biocatalysts to try in synthesis

@narayanlab.bsky.social and @gabegomes.bsky.social designed Catnip--so named because it's "for the biocats"--to make it easier for newbs to use enzymatic reactions in organic synthesis. I had the privilege of hearing them talk about it at #ACSSpring2025 earlier this week!
cen.acs.org/acs-news/acs...

i feel you with this one 😭
i’ve been searching since 2024 and it’s been a doozy

contrary to what many people might think, i did NOT name my wifi network “organic chemistry is easy”

wdym my 3 years of synthesis/biocat doesn’t make me eligible for an entry level synthesis position in industry 🫠

Approx. 5 bullets on what I did this past week:

- singlet or triplet state
- C-H insertion
- cyclopropanation
- ylide formation
- Wolff rearrangement

Don't forget that the lead compound for vertex came from a library developed in collaboration with the Jin Quan Yu lab at Scripps, using CH functionalization

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

first on-site interview: ✅

feels nice to not have to be interviewing from my apartment 😭

I am teaching my favorite course again this semester:
"Chemical Neuroscience - a Synthetic Approach".
We are posting some materials online, check them out.

www.traunergroup.org/teaching

Reading this book 📕 for the third time, might be a blueprint for how Marc Cuban can help build a news 📰 network with journalists like Jim Acosta, who can tell the TRUTH to POWER 💪💪💪 and lead the RESISTANCE 🙏🙏🙏

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

i feel like murphy’s law has kicked itself into overdrive at this point 😭

arguably one of my favorite mechanistic sequences in a total synthesis <3

first the knowles group and now the yoon group???

skeletal editing is on a ROLL today 🤠

absolute BANGER of a skeletal editing & PCET paper 😍

If you went to college/uni
1. what was your career goal when you started?
2. your initial major?
3. if you changed majors, what did you change to?
4. what do you do now?

1. physician-scientist
2. biomedical engineering
3. chemE -> physics -> chem
4. tbd 🫢

“how’s the job search going?”

mass spec position BUT they don’t want chemists and/or people who aim to go to grad school 🫠

Surviving Your First Week in Medicinal Chemistry

Surviving Your First Week in Medicinal Chemistry

Would like to see more perspectives like this in the journal. Going from an academic lab, esp if focused on synthetic organic chemistry, into industrial medicinal chemistry, really is falling through the looking glass.