We're excited to share a new research publication from Dr. Jon Wilson, @glombandit.bsky.social, Dr. Randy Haun, and Dr. Chris Larsen titled "Framework for Apolipoprotein 1-Mediated Kidney Disease Classification."

Read here: www.kireports.org/article/S2468-0249(26)02...

#nephsky

Serine Protease HTRA1 is a Common Autoantigen in Membranous Nephropathy in Patients of 80 Years and Older - PubMed HTRA1 is a common autoantigen in PLA2R-negative MN among very elderly patients, occurring in approximately one in five cases aged 80 years or more. These findings support inclusion of HTRA1 testing in diagnostic evaluation of antigen-negative MN in patients 80 years and older and suggest the existen …

We're proud to share a new publication with @aaronstorey.bsky.social, Dr. Patrick Walker, Dr. Chris Larsen, and @glombandit.bsky.social, titled "Serine Protease HTRA1 is a Common Autoantigen in Membranous Nephropathy in Patients of 80 Years and Older."

🎨 Beautiful visual abstract by Dr Natalia Nombera Natalia Nombera Aznaran #NephJC

Hi 👋. I'm Tiff Caza, a kidney pathologist and #NephJC enthusiast! Interesting topic tonight! No COI.

Proteomic Profiling of Complement Components in Glomerular Disease - PubMed The complement system plays a central role in glomerular disease development and resolution. Currently, renal biopsies assess the presence of complement through limited immunofluorescence stains (C3 and C1q). With more than 50 total proteins and fragments involved in the complement cascade, this met …

We're excited to share a new research publication from @aaronstorey.bsky.social, @glombandit.bsky.social, and Dr. Chris Larsen titled, "Proteomic Profiling of Complement Components in Glomerular Disease."

Read here: https://pubmed.ncbi.nlm.nih.gov/41720186/
#ArkanaResearch #RenalPath #RenalResearch

Nominations are OPEN for the 2026 NephJC Kidneys — NephJC The NephJC Kidneys are back for the eighth year! Nominate you favorites of 2025- 2026!

dont forget to nominate for the #nephJCKidneys

www.nephjc.com/news/2026/1/...

#nephjc

Top Stories in Nephrology 2025 — NephJC 2025 was rich in successful stories. Here are the top 10 that impressed our audience.

It's 2026!🎉
We will be counting down the Top Ten Nephrology Stories of 2025 on 1/6/26 at 9 pm EST.
Join us on TWITTER (it will always be Twitter to us).
Come on by #NephJC faithful for a lively discussion! You picked & we're count'em down.
www.nephjc.com/news/2025/1/3/top-stories-in-nephrology-2025

IgG3κ Monoclonal Membranous Nephropathy Associated With Acquired Lecithin Cholesterol Acyltransferase Deficiency

bit.ly/3Le1OFK

Glom Goals: A Blueprint for Better Renal Biopsies YouTube video by Arkana Laboratories

@nephrosharma.bsky.social and @glombandit.bsky.social
sat down with Dr. Salil Parikh, a radiologist who helped his facility improve their adequacy rates significantly, to discuss one possible blueprint for better renal biopsies. #nephsky #radiology

Listen to the conversation here:

I love that. . . got an issue, get some tissue 😀

IgA Vasculitis

A kidney biopsy is mandatory in patients with persistent proteinuria ≥0.5 g/day for more than 4 weeks, impaired kidney function, or suspicion of rapidly progressive glomerulonephritis (RPGN).

#NephJC

When hematuria is the predominant presentation, does anyone do a genetic workup first or straight to biopsy? #NephJC

Could an increased frequency of IgA vasculitis in children be at play as they are more often proliferative? #NephJC

Great point! #NephJC

Thanks for hosting us!

When there is segmental sclerosis in an IgA nephropathy, patients may never achieve less than 0.5 g proteinuria. How does this impact the course of therapy? #NephJC

The evidence of immunomodulatory effects of steroids and Nefecon comes from the following trials. High dose steroids treatment suffered from complications like infections. Nefecon, however, still showed similar systemic side-effects of other oral steroids.
#NephJC

Treatment Approach: 💊
Novel therapies for IgAN have shifted the paradigm to a bi-pronged approach.
a) Generic responses to HTN/proteinuria
b) Fundamental drivers of nephron loss by reducing the formation of aberrant IgA molecules & the maladaptive mechanisms that contribute to CKD. #NephJC

While it may not be validated for that purpose, is there any utility in post-transplant? #NephJC

Global Implementation of IgAN 2025 guidelines:

#NephJC

As we learn more and develop new treatments, it is important to try to make these available to a wide population of patients. Including low-income patients in future studies might allow for at least some access to cutting edge therapies.

This seems like a low threshold, but interested what others think and do in their practice. #NephJC

First things first — where the story starts!

Time to unpack the 4-hit hypothesis of IgA nephropathy — understanding each step opens doors to new treatments. #NephJC

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC

www.nephjc.com/news/...

Hi 👋. I'm Tiff Caza, a kidney pathologist and #NephJC fan! Looking forward to learning about IgA. No COI. Hoping to see some of you all at Kidney Week next week 🙂

There is a 13-year gap between the approval of new drugs for use in adults and their approval in children. Could extrapolation accelerate clinical trials in pediatric nephrology? Read more in #ASNKidneyNews kidney.pub/KN1710-10

I agree! Super cool. I learned about this at Kidney week in 2022 and signed up with the NKR after. It's a good insurance policy to have a voucher for yourself and great you can list family members too (my kiddos have vouchers🙂)

Renal biopsy adequacy

Did you know inadequate renal biopsies are on the rise?

Recently, Dr. Shree Sharma and @glombandit.bsky.social sat down with Dr. Vandana Niyyar, @nephrowhitt.bsky.social, and @juancarlosqvelez.bsky.social to discuss renal biopsy adequacy and understand why it matters.

Listen to the conversation:

Thanks for hosting us @kidneyboy.bsky.social ! 😊

It's not just TB. . . I think this is still true for a lot of conditions, such as psychiatric diseases, epilepsy, HIV infection, etc #NephJC

That is a crazy high number!?! #NephJC