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Posts by Sholto David

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Karin Dahlman-Wright director of KI’s new research infrastructure organisation Karolinska Institutet has appointed Professor Karin Dahlman-Wright as director of KI’s new research infrastructure organisation, RIKI, with effect from 1 April. RIKI provides the tools, methods, techn...

Former Rector Karin Dahlman-Wright, who was foind guilty of research fraud and sued to avoid sacking, triumphantly returns to @ki.se !
news.ki.se/karin-dahlma...

3 days ago 11 6 2 1
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A Researcher's Sleuthing Journey and How It Led to a $15M Case · Luma A couple months ago, Dana-Farber Cancer Institute agreed to pay $15 million to settle fraud allegations tied to manipulated research images in NIH-funded…

I will chat to Patrick from ImageTwin this week. If you have any questions about the case or analysing images in scientific papers feel free to join. luma.com/0c2016n8

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Billionaire with deep pockets I suppose.

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The Men Who Stare At Mice “Do Cohen’s colleagues and superiors know or care that he hosts wizards in his lab? Or perhaps this is simply common place, wizards roam throughout MD Anderson free range, blasting the …

Previously featured on ForBetterScience: forbetterscience.com/2025/02/26/t...

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Abstract 2228: Biofield therapy inhibits pancreatic cancer invasion and metastasis by modulating multiple steps of metastatic cascade. Abstract. Biofield therapies (BTs) are gaining attention as potential complementary treatments for cancer. Some devices have been developed to mimic the energetic or electromagnetic fields emitted by BT practitioners. We previously reported that BT significantly inhibited growth and invasiveness of pancreatic cancer cells in vitro and in relevant animal models. To identify which steps of the metastatic cascade are affected by BT and to elucidate potential antimetastatic mechanisms in pancreatic ductal adenocarcinoma (PDAC), we conducted in vivo studies using metastatic mouse models. In a KPCY orthotopic model, BT treatment significantly reduced the percentage of visible liver nodules by 61.3% and 54.6% compared with the colony control (CC) and sham control (SC) groups, respectively (p < 0.05). Imaging of YFP+ cells in the liver tissues revealed a significant reduction in disseminated tumor cells in the BT group relative to CC and SC groups (p < 0.05). In a tail-vein injection model, lung tissues from BT treated mice exhibited a significant 59.6% reduction in YFP+ signal intensity compared with SC mice, supporting the conclusion that BT suppresses metastatic dissemination of PDAC cells. BT treated mice bearing PANC-1 orthotopic tumors had significantly lower levels of tumor cell-free DNA (11.5 ± 4.6 ng/μl) compared with sham control (24.7 ± 7.9 ng/μl; p < 0.01), suggesting that BT treatment impairs tumor cell intravasation. This is consistent with our previous findings that BT inhibits EMT in human PDAC PANC-1 cells. Additionally, BT induced anoikis in PANC-1 cells, indicating that BT may also reduce PDAC cell survival in circulation. To investigate whether BT affects metastatic colonization, both PANC-1 and KPCY cells were exposed to BT and subjected to adhesion assay using phalloidin staining and fibronectin quantification, as fibronectin is a key regulator of cell adhesion. PANC-1 cells exposed to BT for 15 mins showed an average of 14 ± 4 adhered cells per field, compared with 96 ± 35 in the SC group (p < 0.0001). Similarly, fibronectin-based cell adhesion measurements showed a 58.3% decrease in BT-treated PANC-1 cells relative to SC (p < 0.001). BT also significantly reduced F-actin intensity in PANC-1 cells (p < 0.01), with similar results observed in KPCY cells after 30 min of treatment. Epigenetic profiling further revealed that BT modulated the expression of genes involved in actin cytoskeleton regulation. Collectively, these results demonstrated that biofield therapy suppressed multiple metastatic steps including cell invasion/migration, intravasation, survival in circulation, and colonization ultimately contributing to its antimetastatic effects in PDAC models. These processes may be mediated in part through alterations in cytoskeleton organization, particularly actin dynamics.Citation Format:. Peiying Yang, Sharmistha Chakraborty, Phuong Nguyen, Defeng Deng, Amanda Eckstrom, Andrew Cusimano, Daoyan Wei, Lorenzo Cohen. Biofield therapy inhibits pancreatic cancer invasion and metastasis by modulating multiple steps of metastatic cascade [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 2228.

Quite how he is allowed to torture mice like this is mysterious to me, but perhaps we will be entertained with a new paper eventually. aacrjournals.org/cancerres/ar...

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Lorenzo Cohen at MD Anderson presented "Biofield Therapy" results at AACR last week. "Biofield Therapy" sounds scientific but is just a fancy name for telekinesis - AKA staring at mice. Actual photo from his lab below, now deceased psychic staring at mice. Not clear who does the staring these days.

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Chris Gaffe: “Scientific Reports has an in-house team who are dedicated to ensuring that the journal operates with integrity. They are an excellent team who care enormously about the journal and the research it publishes."

"oxygenaonol", "cen̈rifiugation", "Cos aspe-9"

pubpeer.com/publications...

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The Trivedi Effect “Mahendrakumar Trivedi does not need a Potion to make you fatter and more delicious; his psychic emanations are enough.”- Smut Clyde

forbetterscience.com/2026/04/07/t...

2 weeks ago 1 1 0 1

Yawn. It's not political. Before you bother with another lecture go read the settlement.

2 weeks ago 2 0 0 0
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The case was filed under the Biden administration. It's not political.

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I Sued the Dana-Farber Cancer Institute for Research Fraud and Won $2.6 Million Dollars
I Sued the Dana-Farber Cancer Institute for Research Fraud and Won $2.6 Million Dollars YouTube video by Sholto David

Now that I have finally been paid I made a video about the Dana-Farber legal case from my own perspective: youtu.be/ioRtnMEV46Y

2 weeks ago 53 17 2 8

Gorilla Troops Optimizer!

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Obviously, this is not the only great use case of this tortured phrase. See here, in the context of embryo cryopreservation: doi.org/10.31674/boo...

2 weeks ago 4 1 1 1

Ahahahahaha. @bmj.com first issued a correction to remove the English guys, Anthony Mathur and Sheik Dowlut, as innocent victims of impersonation.
Only then did BMJ retract that Iranian papermill fraud!
forbetterscience.com/2025/11/05/b...

2 weeks ago 13 6 2 1

Brilliant, I was really dumbfounded.

3 weeks ago 2 1 0 0
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Oh nothing, just a peer reviewed paper my colleagues found...
doi.org/10.1016/j.ma...
"1 mL of the mass killing of an ethnic group was opposed to 20 mL of the skin sample and unprotected to light for 7 min."

Even AI knows what's wrong here, but @elsevierconnect.bsky.social doesn't.

3 weeks ago 206 83 15 29
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Perfect Blots “A coordinated review of the cited publications and underlying data is currently underway” – Hiroki Kuniyasu

I have been blogging again at For Better Science, this time a case of an epic image fraud from a Japanese lab: forbetterscience.com/2026/03/24/p...

3 weeks ago 8 4 0 0
PubPeer - Targeting claudin-4 enhances CDDP-chemosensitivity in gastri... There are comments on PubPeer for publication: Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer (2019)

There are some differences; mostly in vertical stretch, quality, brightness and contrast, the image on PubPeer is quite large and the similarities should be clear: pubpeer.com/publications...

1 month ago 6 1 0 0
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The same western blot image used 23 times in 14 different papers by one Japanese team. The image has been labelled as representing a range of experiments and proteins. This is the most I have ever seen. Perhaps it is a record?

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Attack is the best form of defence.

1 month ago 2 0 1 0

In retrospect it was a bad idea to train the LLM on dialog from Tarzan movies.

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Scientific Reports 2025: A Year in Review “In this blog I write about papers published by Scientific Reports in 2025, so we could consider it to be a sort of “wrap-up” of highlights and special achievements in the world&#…

Scientific Reports is not a serious journal: forbetterscience.com/2026/01/06/s...

1 month ago 4 1 0 1

I'm not even convinced that the text was produced by an honest researcher writing in a second language. It appears to be some kind of language transformation, perhaps English into Chinese into English as suggested above. In any case, if you can't read your own paper, you simply shouldn't submit it.

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Tortured phrases: A dubious writing style emerging in science. Evidence of critical issues affecting established journals Probabilistic text generators have been used to produce fake scientific papers for more than a decade. Such nonsensical papers are easily detected by both human and machine. Now more complex AI-powere...

A good observation, this might even be how it was generated, it's not the usual thesaurus type method of traditional tortured phrases: arxiv.org/abs/2107.06751

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The rest of the paper is normal?

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Just read the abstract 🫠 via Alexander Magazinov. I don't believe he is on Bluesky.

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Many papers do not (truthfully) state where they got their cells from. "Acquired from the ATCC seems" like more of an aspirational statement, often papers claim this even when cell lines have never been sold by the ATCC.

1 month ago 3 0 0 0
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This seems to indicate the widespread use of either contaminated cell lines or non-specific antibodies (or worse). Of course since so few papers actually specify what antibodies they used it is quite difficult to pick these things part.

1 month ago 2 0 1 0

There are a number of cell lines with documented genetic deficiencies: PC-3 cannot express PTEN (PMID: 9661880), A549 cannot express STK11 (LKB1) (10.1038/sj.onc.1207502)... Still, just scrolling through google images you can find recent papers uncritically presenting contradictory results.

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