Lots of exciting new scores in our latest release! Including:
- Multiple metabolic PRS: www.pgscatalog.org/publication/...
- First score for Eosinophilic Esophagitis: www.pgscatalog.org/score/PGS012...
& much more! Share your data at www.pgscatalog.org/submit!
We hope it's easy to use with tutorials for UKB (pgsc-calc.readthedocs.io/en/v3-alpha....) & All of Us (pgsc-calc.readthedocs.io/en/v3-alpha.... )! But feel free to contact us on Github: github.com/PGScatalog/p...!
With that, happy holidays from the PGS Catalog team! 🎁 🎄
The new alpha only implements PGS scoring at the moment, but the roadmap will reimplement our existing genetic ancestry tools! Lot's of under-the-hood optimisation using python (zarr, dash), and it only takes VCF or BGEN input atm. github.com/PGScatalog/p...
Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/
Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).
Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!
🚨 Countdown to #ASHG25: Predicted Effector Gene standard is coming! 🚨 Join us and be part of the conversation!
📌 Poster Oct 16 | 2:30–4:30 | Poster Hall
🗓️ Session Oct 17 | 11:45–1:15 | Room 259A
Learn more: kpnashg2025.wordpress.com/pegs-workshop/
At #ASHG25 and want to meet members of the GWAS Catalog & PGS Catalog teams? Stop by the @impc-phenotypes.bsky.social booth 1420 where we're helping out!
Some recent data:
- First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social): www.pgscatalog.org/publication/...
- Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/...
Share PGS 👉 www.PGSCatalog.org/submit!
Check out the latest and most powerful polygenic scores for body mass index and obesity from @roelofajsmit.bsky.social et al. in the PGS Catalog: www.pgscatalog.org/publication/.... Thanks to the authors for submitting the data pre-publication! Submission information @ www.pgscatalog.org/submit
At #ISMB2025 in Liverpool? Interested in polygenic scores? Ben Wingfield will be back at his poster this afternoon at 4 PM (B507 / TransMed) to discuss all things pgsc_calc - our portable, scalable Nextflow workflow, designed for PGS calculation at scale in TREs! Go say hello!
Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!
Great to see so many PGS Catalog IDs in the wild on posters at #ESHG2025, #OpenData and #FAIRdata for all! Users and submitters are the lifeblood of the resource, get in touch if you ever have feedback or suggestions for improvement!
Great fun sharing the @pgscatalog.bsky.social at the pre- #ESHG25 course on open-source genomics resources. Thanks to Juliana Cerqueira and Inga Prokopenko for the invite!
Looking forward to the rest of the conference!
Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!
🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data.
Check it out 👇. It is very cool!
geneticscores.org
It is linked with the @pgscatalog.bsky.social
This was supported by INTERVENE
Another highlight from this release is a new score for all-cause dementia, 🔗: www.pgscatalog.org/score/PGS005.... Thanks to D'Aoust et al. for sharing!
Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!
Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!
Discover data from our latest release:
- New PGS for atrial fibrillation (buff.ly/E1TkmKv)
- PGS optimised for East Asian ancestry in cancer (buff.ly/gLkYKVo) and 10 other common diseases (buff.ly/nG7rOIq)
Find out how to submit your data here: buff.ly/nJCjUMr
Online tutorial Polygenic scores and the PGS Catalog Predicting genetic risks and traits Access anytime, anywhere
We're pleased to announce our latest free online tutorial! This is for anyone who wants to find out more about polygenic scores and how to explore the data in the PGS Catalog: www.ebi.ac.uk/training/onl...
Produced in collaboration with @pgscatalog.bsky.social
📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!
Also out today is this multi-ancestry PGS for PSA! 🔗: www.pgscatalog.org/publication/...
Now available in the PGS Catalog 🔗: www.pgscatalog.org/publication/...! Thanks to authors like Sean for submitting the data directly, find out how to submit your data at pgscatalog.org/submit
Welcome @omicspred.bsky.social (www.omicspred.org) to 🦋! OmicsPred focuses on curating genetic scores for omics-traits (genes, proteins, metabolites) to power large-scale association analyses. Check it out!
Are you going to #FOG2025? Meet us to learn about the integration of processes with PGSCatalog or metadata generation and harmonisation pipelines for #SumStats. Share your data bit.ly/38rNSjx #openaccess
Gif of Julie Andrews singing "Let's start at the very beginning" from Sound of Music.
Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!
If you're interested in the PGS Catalog Calculator we're hosting a free training webinar @ebi.embl.org on December 4th: www.ebi.ac.uk/training/eve... (registration required). Come along, or catch up with the recording after!
cc @iamslambert.bsky.social
The Catalog isn't just a knowledgebase and source of polygenic scores, we also provide open-soruce tools to make PGS calculation easier and more reproducible! You can find our pgsc_calc tool on github (github.com/PGScatalog/p...) with extensive documentation (pgsc-calc.readthedocs.io/en/latest/).
Gif of Julie Andrews singing "Let's start at the very beginning" from Sound of Music.
Let's start with introductions! The PGS Catalog is an open database of polygenic scores and the relevant metadata required for accurate application and evaluation. Everything is on our website www.PGSCatalog.org, and our newest publication describes how far we've come: rdcu.be/d1vTG since 2019!