🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Thanks for featuring our work on how emerging tumour remodel their nascent niche 🌱promoting their survival @cam.ac.uk, @scicambridge.bsky.social , @cruk-ci.bsky.social, @pdncambridge.bsky.social

www.stemcells.cam.ac.uk/news/alcolea...

www.nature.com/articles/s41...

'Mechanisms of cellular fitness and cell competition: Towards an integrated view'
www.sciencedirect.com/science/arti...

'Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer'
www.nature.com/articles/s41...

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength - Nature Aging With aging, somatic mutations accumulate in cellular DNA; however, whether they drive age-related functional decline is incompletely understood. Here the authors show that these mutations can weaken m...

'Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength'
www.nature.com/articles/s43...

'The Somatic Mosaicism across Human Tissues Network'
www.nature.com/articles/s41...

'Cross-tissue multicellular coordination and its rewiring in cancer'
www.nature.com/articles/s41...

"Cell cycle duration determines oncogenic transformation capacity"
www.nature.com/articles/s41...

'Neural cell competition sculpting brain from cradle to grave'
academic.oup.com/nsr/article/...

'Geographic and age variations in mutational processes in colorectal cancer'
www.nature.com/articles/s41...

'Emergence and properties of adult mammalian epidermal stem cells'
www.sciencedirect.com/science/arti...

'Clonal driver neoantigen loss under EGFR TKI and immune selection pressures'
www.nature.com/articles/s41...

Hundsdorfer, L., Muenkel, M., Aparicio-Yuste, R., ..., Mostowy, S., & Bastounis, E. E. (2025). ERK activation waves coordinate mechanical cell competition leading to collective elimination via extrusion of bacterially infected cells. Cell reports, 44(1), 115193. #EpithelialMechanics
buff.ly/g0GPOtr

🛫You won’t want to miss us in stunning Malta!🌴🏖️ Get ready to be inspired at the STEM CELLS & CANCER conference. INCREDIBLE LINE-UP of speakers!

🎙️Cedric Blanpain @cedric-blanpain.bsky.social
🎙️Peter Dirks
🎙️Catriona Jamieson… and more 🧵

📅 September 28, 2025
🔗 bit.ly/49sCfJp

@fusionconf.bsky.social

'Translating premalignant biology to accelerate non-small-cell lung cancer interception'
www.nature.com/articles/s41...

'The end of the genetic paradigm of cancer'
journals.plos.org/plosbiology/...

Matrix-producing neutrophils populate and shield the skin Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

'Cancer evolution: from Darwin to the Extended Evolutionary Synthesis'
www.cell.com/trends/cance...

'Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis'
www.cell.com/cancer-cell/...

The complex interplay between aging and cancer - Nature Aging This Review explores the intersection between cancer and aging, illustrating shared causal mechanisms including genome instability, telomere dysfunction, cellular senescence and dysregulated immunity ...

'The complex interplay between aging and cancer'
www.nature.com/articles/s43...

'Clonal dynamics and somatic evolution of haematopoiesis in mouse'
www.nature.com/articles/s41...

'Exposomal determinants of non-geneticplasticity in tumor initiation'
www.cell.com/trends/cance...

'Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation'
www.sciencedirect.com/science/arti...

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...

So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...

✈️Join us in paradise!

The stunning Malta will be the perfect setting to stimulate great discussions on Stem Cell and Cancer Biology 🔬

World-leading experts will share their exciting science.

🗓️Fusion Conference Stem Cells & Cancer! September 28, 2025

bit.ly/49sCfJp

We are all mosaics Picture your body: It’s a collection of cells carrying thousands of genetic mistakes accrued over a lifetime — many harmless, some bad, and at least a few that may be good for you.

A nice article covering some of the surprises in the field of somatic mosaicism in the last decade. As I say there: "Judging by the discoveries that we are making at the moment, the journey has only just started. I expect many surprises in the next few years." knowablemagazine.org/content/arti...

'Spatiotemporal single-cell roadmap of human skin wound healing'
www.cell.com/cell-stem-ce...

'Spatial transcriptomic clocks reveal cell proximity effects in brain ageing'
www.nature.com/articles/s41...

'iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells'
www.nature.com/articles/s41...