"While CD8+ T cells primed exclusively by either cDC1 or cDC2 cells showed phenotypic differences, both could mediate anti-tumour responses and memory formation."
www.nature.com/articles/s41...
For Chongqing/Sichuan hotpot, you normally need to dip your food in sesame oil (fat) before putting it into your mouth.
High-fat diet causes rapid loss of intestinal group 3 innate lymphoid cells through microbiota-driven inflammation and mitochondrial stress: Immunity www.cell.com/immunity/ful...
So perhaps everyone needs to have a regular and balanced diet, even though fasting might be a fashion for someone at some time.
Fasting impairs humoral immunological memory by β-hydroxybutyrate-mediated depletion of plasma cells: Immunity www.cell.com/immunity/ful...
18 sites across India
12717 household contacts
VPM1002 showed vaccine efficacy of 21.4%, 19.5%, and 50.4% (95% CI: 0.8% to 75.2%) against all TB, PTB, and extrapulmonary TB, respectively.
Immuvac showed vaccine efficacy of 33.2% against extrapulmonary TB.
www.bmj.com/content/393/...
should be: add_violin(trim = FALSE)😀
tested in tidyplots v0.4.0 of Windows 11.
"AT-108, a replication-deficient adenoviral vector encoding the human PU.1, IRF8, and BATF3 transcription factors (1), enables in vivo cell-fate conversion of cancer cells and other cells in the tumor microenvironment (TME) into induced cDC1-like cells (iDC1s)"
www.science.org/doi/10.1126/...
Copy paste into the address bar of your browser for a random generative artwork. No AI involved.
"This (i.e. in vivo CAT T) cut enrollment-to-treatment time to eight hours, compared to several weeks for ex vivo CAR T."
www.nature.com/articles/s41...
library(pak) # install the latest CRAN release pak("tidyplots") # install the development version pak("jbengler/tidyplots") # install a specific version pak("jbengler/tidyplots@v0.0.1") # install a specific commit pak("jbengler/tidyplots@9f7294a")
This is how you can install a specific version of a package 🤓
In these cases 📦 pak.r-lib.org comes in very handy
#rstats #dataviz #phd
5 candidates in phase 3.
"Current clinical development pipeline of preventive tuberculosis vaccines"
www.thelancet.com/journals/lan...
What we should be doing, but we're not:
"Arming the immune system for the next zoonotic coronavirus spillover"
A nasal dendritic-cell targeting vaccine that prevents viral transmission vs pan-sarbecovirus clades (i.e. all coronaviruses, irrespective of variants)
www.jci.org/articles/vie...
2. Stay in the field long enough and people will find you. You don't need to go viral. You just need to keep showing up and sharing what you know. Consistently. For years.
Pros and cons of NK cells from different sources.
link.springer.com/article/10.1...
"HLA-independent T cell (HIT) receptor (26), which substitutes the antigen recognition domain of a T cell receptor (TCR) with that of a CAR, thereby co-opting the downstream signaling afforded by the CD3 complex"
www.science.org/doi/10.1126/...
"Assembloids ... are fusion structures that can combine multiple organoid types for the purpose of accounting for inter-regional interactions or can even incorporate missing cell types within the same organoids."
"Organoids, also referred to as ‘mini-organs’, are three-dimensional (3D) in vitro grown structures exhibiting either complete or partial resemblance to in vivo organs in terms of cellular organization, microanatomy and architecture."
pmc.ncbi.nlm.nih.gov/articles/PMC...
iCLAP: integrable Co-detection of Low-Abundant Proteins.
"enables sensitive and highly multiplexed protein detection within the same FFPE tissue section"
www.nature.com/articles/s41...
4i: iterative indirect immunofluorescence imaging.
www.science.org/doi/10.1126/...
IMC: imaging mass cytometry.
"coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass cytometry."
www.nature.com/articles/nme...
t-CyCIF: tissue-based cyclic immunofluorescence.
"conventional low-plex fluorescence images are repeatedly collected from the same sample and then assembled into a high-dimensional representation."
elifesciences.org/articles/31657
CODEX: CO-Detection by indEXing.
Multiplexed DNA-tagged antibody staining.
www.cell.com/cell/fulltex...
There are two nonavalent HPV vaccines, one approved by the FDA in the USA (2014), the other one approved by the NMPA of China (2025).
www.mdpi.com/2076-393X/14...
"hypoxia correlates with immune cell state and organization within granulomas and might subvert immunity to TB"
www.nature.com/articles/s41...
I only knew the transwell assay and the wound healing assay.
"The median age of patients with HAdV infection was 3 years, with infants aged 0-2 years accounting for the majority (41.39 %)."
www.sciencedirect.com/science/arti...
“intranasal **DNA vaccine** fusing the Mtb ... relMtb with the gene encoding the dendritic cell-targeting chemokine Mip3a/CCL20”
JCI - Immunotherapy targeting drug-tolerant Mycobacterium tuberculosis persisters accelerates tuberculosis cure in preclinical models www.jci.org/articles/vie...
Furthermore, the ratio of activated (CD38+ HLA-DR+) versus exhausted (TIM-3+PD-1+) CD8+ T cells was higher in the early ToD group (P < 0.001) compared with the late ToD group (P < 0.001).
"Over the first four cycles (of immunotherapies), morning circulating CD8+ T cells increased in the early ToD (time of day, before 15:00) group, whereas they declined in the late ToD (after 15:00) group (P < 0.001)."
TIL:
mtcars |> _$cyl
"x" |> assign(1)