What’s inside your Coke Zero? 🧪🥤
Ever wondered what a sugar-free drink looks like at the molecular level? This is a 600 MHz ¹H NMR spectrum of Coca-Cola Zero (Ukrainian edition).
Even without sugar, the chemistry is dense! Here’s the breakdown:
👇🧵
#nmr #nmrchat #dietcoke

PERUGIA EN FINALE ! 🎫

Les Block Devils s’imposent en balayant Piacenza en 3 sets et se qualifient pour la finale de la SuperLega 🇮🇹

(27-25, 25-21, 25-15)

📸 LegaVolley

The next chapter in ADP-ribosylation biology: modification of uracil and guanine bases by PARP10 and PARP15

www.biorxiv.org/content/10.6...

Three-dimensional structure of the palbociclib–HIV TAR complex Abstract. We present the structure of the HIV-1 transactivation response (TAR) element bound to the kinase inhibitor palbociclib, a single-digit nM ligand

Three-dimensional structure of the palbociclib–HIV TAR complex url: academic.oup.com/nar/article/...

Congratulations to Claudia Höbartner (@chlab.bsky.social) on being awarded the very prestigious Albrecht-Kossel-Preis by the @gdch.de at #Biochemistry2026!

Prof. Höbartner receives this award for the first structure of a DNAzyme and the development of methyl transferase ribozymes. (1/2)

Associate/Full Specialist (Facility Scientist) - Pines Magnetic Resonance Center (PMRC) Core Facility - College of Chemistry University of California, Berkeley is hiring. Apply now!

NMR Facility Manager (Facility Scientist), Pines Magnetic Resonance Center (PMRC) Core Facility, College of Chemistry, the University of California Berkeley, must be authorized to work in U.S. Visa sponsorship is not available aprecruit.berkeley.edu/JPF05294 #NMRjobs #NMRchat #NMR 🧲

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence This study explores the origins of life by linking prebiotic chemistry, the emergence of information-carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The ....

Our new review in @angewandtechemie.bsky.social is out! It explores the role of chemistry in emergence and complexity at the boundaries with biology, physics, and philosophy.
A perspective on chemistry contributing to these interdisciplinary questions.

onlinelibrary.wiley.com/doi/10.1002/...

"Die fallen auf jeden KI-Müll rein" – Jugendliche fordern Social-Media-Verbot für Menschen über 40 Berlin (dpo) - Gibt es bald ein Social-Media-Verbot für Über-40-Jährige? In einer Pressekonferenz haben genau das Jugendliche heute gefordert. Ihre Fo

"Die fallen auf jeden KI-Müll rein" – Jugendliche fordern Social-Media-Verbot für Menschen über 40 www.der-postillon.com/2026/02/soci...

RNA, Why it is still a Big Deal The World Economic Forum Annual Meeting 2026 discusses the rapid development of RNA technologies and their impact on global health innovation.

www.weforum.org/meetings/wor...

Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides A multienzyme was formed and evaluated by covalently linking 4-coumarate ligase (4CL1) from Piper methysticum to a non-reducing murine fatty acid synthase. 4CL1 acylates the acyl carrier protein (ACP....

New in Angewandte 🔥: With two engineered changes, we reprogram mammalian fatty acid synthase to make pyrones instead of fatty acids! 🧬 Congrats Felix, Nadja & Caro! We delete the processing part + tweak the KS pocket, even mimicking PKS-like initiation. Paper: doi.org/10.1002/anie...

🚨We are looking for a coordinator located at @uni-wuerzburg.de for our new excellence cluster NUCLEATE - Cluster of Nucleic Acid Sciences and Technologies 👇
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026

2'dGswitch, most beautiful of all RNAs, my companion from the first to the literally last day :)

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions Understanding the molecular recognition underlying RNA–ligand complex formation is of key importance to explain the RNA regulatory function of riboswitches and to support the development of low-molecu...

DNP-Enhanced Magic Angle Spinning Solid-State NMR Spectroscopy to Determine RNA–Ligand Interactions | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...

CASP RNA SIG Welcome nucleic acid enthusiasts to the Special Interest Group (SIG) focused different aspects of nucleic acid 3D structure prediction, including but not limited to obtaining experimental data, buildi...

Recording (and most of our past seminars) are released here, www.youtube.com/@CASPRNASIG, enjoy!

Physicists explore the formation and behavior of “sandballs”—the peanuts, doughnuts, and orbs of sand and water that form when raindrops hit a sandy slope. Sandballs have implications for bioengineering, pharmaceuticals, and snow physics. In PNAS: https://ow.ly/aitg50XOW8U

EMBO @embo.org Practical Course, Structural dynamics, interactions and function of biological macromolecules by NMR, July 24-31, 2026, Bayerisches NMR-Zentrum (BNMRZ) Technical University of Munich, Garching
embo2026.bnmrz.org Application & registration will open in January #NMRchat 🧲

Are you interested in cutting-edge #Biochemistry and #ChemBio? Join us for the GDCh #Biochemistry2026 conference in Würzburg on March 16th to 18th, 2026.

Registration is now open and you can submit an abstract until January 10th, 2026: veranstaltungen.gdch...
(1/2)

Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Abstract. RNA aptamers obtained from in vitro selection experiments provide unique insights into the structural properties and ligand recognition capabilit

Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex url: academic.oup.com/nar/article/...

✅ FIM DO PRIMEIRO SET! #ClubWCH

🏐 (0) 🔴 Sir Sicoma Perugia 23x25 Osaka Bluteon 🔵 (1)

Andre Agassi, Rick Leach, John McEnroe, Pete Sampras, Jim Courier, el equipo que llevó a Estados Unidos 🇺🇸 a ganar la Copa Davis en 1992. Posiblemente el mayor Dream Team de la historia del tenis 🎾

⏰Call for Applications - Join Our Team and Help Shape Our Cluster

@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!

FEBS Advanced Lecture Course 2026 – Lost in integration vol. 2: Probing biomolecules with AI and experiments 10–16 May 2026 │ Spetses Island, Greece

probingbiomolecules2026.febsevents.org

NMR is for Everyone: Building is a Strength of our Community, Rachel Martin

NMR is for Everyone: Building is a Strength of our Community, Rachel Martin @rwmartin.bsky.social publikationen.bibliothek.kit.edu/1000188105 #NMRchat 🧲

How Winter Spiders Keep Their Blood From Turning To Ice Most spiders shut down when temperatures slip below freezing, but Clubiona spiders keep hunting through subzero nights in European orchards, an improbable winter endurance that depends on potent antifreeze proteins flowing through their bodies. In work published November 19, 2025 in The FEBS Journal, researchers from Queen’s University in Ontario and collaborators in Czechia analyzed ... Read more

Most spiders shut down when temperatures slip below freezing, but Clubiona spiders keep hunting through subzero nights in European orchards, an improbable winter endurance that depends on potent antifreeze proteins flowing through their bodies.

Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements A combined virtual and nuclear magnetic resonance (NMR)-based screening approach identifies small molecules that bind conserved SARS-CoV-2 RNA structures. Diverse compound libraries are screened usin....

Integrative In Silico and In Vitro Screening of Low Molecular Weight Compounds Targeting SARS‐CoV‐2 RNA Elements - Toews - ChemBioChem - Wiley Online Library chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

We are hiring a PhD student!!
The project starts as early as January 2026 and is fully funded for three years.
Everyone with interest in NMR-centered structural biochemistry of nucleic acid-protein interactions in virus-infected cells, get in contact!
biochemie.uni-greifswald.de/forschung/fo...

Noncanonical RNA binding of human La-related protein 6 Abstract. La-related proteins (LARPs) are RNA-binding proteins that are involved in a variety of disease-related processes. Most LARPs recognize short sing

Congrats Robert! My very first #nmr on #RNA buddy 😀

Noncanonical RNA binding of human La-related protein 6 url: academic.oup.com/nar/article/...

#NMR meeting #MD: s2m omikron #RNA, reloaded:
m.rnajournal.cshlp.org/content/earl...

Structural basis for ligand recognition in the tobramycin riboswitch Abstract. Recently, a novel tobramycin-responsive riboswitch was developed by a combination of Capture-SELEX and in vivo screening. This riboswitch regulat

This is what comes out if real heroes of NMR on RNA strike (again): enjoy :)

Structural basis for ligand recognition in the tobramycin riboswitch url: academic.oup.com/nar/article/...

Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight We present the development of low molecular weight inhibitors that target the 5′-terminal RNA stem-loop 1 (SL1) of the SARS-CoV-2 genome. SL1 is crucial for allowing viral protein synthesis in the context of global translational repression in infected cells. We applied compound- and RNA-detected nuclear magnetic resonance spectroscopy (NMR) experiments to guide a fragment-growth strategy based on two primary NMR screening hits from a diverse fragment library poised for follow-up chemistry. These primary hits with molecular weights of around 200 Da were derivatized with the aim of improving the initial solubility, binding affinity, and target specificity. We used NMR to monitor solubility changes, binding affinity, and specific binding to the SL1 binding pocket during the fragment derivatization campaign. Compounds scoring the best in all three categories were further tested for their inhibitory effect on SL1 in a cell-free translation assay, where the best two compounds, A.2 and A.13, showed both significant and selective inhibition. Our results demonstrate that small molecules targeting translation initiation of SARS-CoV-2 can be rapidly obtained using NMR-guided medicinal chemistry, and that the correlation between affinity, selectivity, and in situ function of the derived compounds is still to be explored.

Targeting the SARS-CoV-2 RNA Translation Initiation Element SL1 by Molecules of Low Molecular Weight | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/...