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Posts by Rafa F Leiro

Automated and modular protein binder design with BinderFlow

Automated and modular protein binder design with BinderFlow

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Automated and modular protein binder design with BinderFlow [new]
Streamlines protein binder design by providing a modular, automated, and easily monitored pipeline, increasing accessibility and scalability.

7 months ago 3 3 0 0

Automated and modular protein binder design with BinderFlow www.biorxiv.org/content/10.1101/2025.09....

7 months ago 1 1 0 0

Happy to have hosted @rfleiro.bsky.social in @mpi-nat.bsky.social and hear the cool science he is doing in @cniostopcancer.bsky.social. Watch out for him!

1 year ago 3 2 0 0
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Machines acting on DNA and RNA, a molecular mechanistic perspective (#CFM_MolMech)

See you in Madrid! Speakers include:
@costalaboratory.bsky.social @piratefernandez.bsky.social @nhoitsma.bsky.social @kellythd-nguyen.bsky.social @lapassmore.bsky.social @alessandrovannini.bsky.social @oscarllorca.bsky.social @rfleiro.bsky.social @nogaleslab.bsky.social
www.cnio.es/en/eventos/m...

1 year ago 4 4 0 0
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🔎#CFM_MolMech: a meeting exploring the integration of structural, biochemical, and biophysical insights into cryo-EM advances that reveal molecular machines behind DNA/RNA processes.

👥 Meet the organisers: @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.

📆May 28-30th

1 year ago 6 7 0 0
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🔴⚠CNIO-CaixaResearch Frontiers Meetings: Machines acting on DNA and RNA, a molecular mechanistic perspective.

📆May 28-30th

👥 @oscarllorca.bsky.social, @rfleiro.bsky.social and @nogaleslab.bsky.social.

🔗www.cnio.es/eventos/machines-acting-...

1 year ago 6 8 0 0
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El CNIO incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas Las células se adaptan a las condiciones del ambiente y a los nutrientes que tienen a su disposición. Lo hacen por medio de grupos de proteínas -técnicamente se llaman complejos de proteínas-, que det...

“El CNIO ha estado construyendo una base importante en crio-microscopía electrónica”, dice Tafur; “la experiencia de grupos como el de @rfleiro.bsky.social y el @oscarllorca.bsky.social pueden complementarse con la nuestra de manera muy enriquecedora”, explica Tafur.
www.cnio.es/noticias/el-...

1 year ago 3 1 0 0
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🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍

I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.

1 year ago 27 11 2 2
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De novo designed proteins neutralize lethal snake venom toxins - Nature Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...

Pretty cool work on designing antivenoms de novo! 😱😻👏

www.nature.com/articles/s41...

1 year ago 58 17 2 2

We are still looking for candidates to apply for PhD and postdoctoral fellowships. Get in touch with us if you are interested in learning about the functional architecture of replisome protection using strand-specific genomics and AI modeling of molecular interactions!!!

1 year ago 2 2 0 0
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El CNIO incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas Las células se adaptan a las condiciones del ambiente y a los nutrientes que tienen a su disposición. Lo hacen por medio de grupos de proteínas -técnicamente se llaman complejos […]

🔬El #CNIO incorpora un nuevo grupo para ‘fotografiar’ a nivel atómico y en 3D las estructuras que hacen invasivas a las células cancerosas.

www.corresponsables.com/actualidad/c...

1 year ago 3 1 0 0
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El CNIO incorpora un grupo para fotografiar a nivel atómico las estructuras que hacen invasivas a las células cancerosas

El CNIO incorpora un grupo para fotografiar a nivel atómico las estructuras que hacen invasivas a las células cancerosas

1 year ago 2 1 0 0
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REGISTRATION OPEN!! - CNIO meeting, Machines acting on DNA and RNA, 2025 May 28-30th in Madrid, organized by @nogaleslab.bsky.social , @rfleiro.bsky.social , and @oscarllorca.bsky.social

1 year ago 5 3 1 0
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Maria Blasco, directora del CNIO: “Soy víctima de una campaña, ni un euro contra el cáncer se ha destinado al arte” La responsable del mayor centro de investigación contra el cáncer de España, en el ojo del huracán por su gestión, responde a las informaciones que apuntan a desviaciones de fondos y acoso laboral en ...

I don't know what happened here, but I do know that @cniostopcancer.bsky.social is one of very few places in Spain for excellent science. Care should be taken to protect the institute and its scientists from inaccurate reporting.

www.eldiario.es/sociedad/mar...

1 year ago 9 1 0 0
Sjors Scheres - LMB Through the Years
Sjors Scheres - LMB Through the Years YouTube video by MRC Laboratory of Molecular Biology

Watched this really insightful talk by @sjorsscheres.bsky.social and thinking why on earth they'd decide to have a random keyboard as decoration --

13 mins in Sjors tells why and its kinda heartwarming for computational folks!

youtu.be/SoXAac2HIrY?...

1 year ago 10 4 0 0

I felt special for a moment 😝

1 year ago 2 0 1 0

hello world! looking forward to a more sane and focused scrolling and interactions 😊

1 year ago 16 3 2 0