Montana's 'Right to Try law' (SB422 & SB535) lets people seeking anti-aging treatments access experimental therapies post-Phase I trials. Should we have this be a blueprint for development of anti-ageing therapeutics 🧬 #RightToTry #Montana #Longevity fastdemocracy.com/bill-search/...
21. 🐟 Warty oreo: 140 yrs
22.🐢 Eastern box turtle: 138 yrs
23. 🐢 Mediterranean spur-thighed tortoise: 127 yrs
24. 🧑 Human: 122.5 yrs
25. 🐢 European pond turtle: 120 yrs
Source: AnAge Database
14. 🌰 Red sea urchin: 200 yrs
15.🐢 Galapagos tortoise: 177 yrs
16.🐚 Pacific geoduck: 168 yrs
17.🐟 Shortraker rockfish: 157 yrs
18.🐟 Lake sturgeon: 152 yrs
19. 🐢 Aldabra tortoise: 152 yrs
20.🐟 Orange roughy: 149 yrs
6. 🌳 Umbrella thorn: 650 yrs
7. 🐚 Ocean quahog clam: 507 yrs
8. 🦈 Greenland shark: 392 yrs
9. 🪱 Escarpia laminata: 300 yrs
10. 🌵 Saguaro: 300 yrs
11. 🪱 Lamellibrachia luymesi: 250 yrs
12. 🐋 Bowhead whale: 211 yrs
13. 🐟 Rougheye rockfish: 205 yrs
Some organisms make human lifespans look incredibly short 🤯
🧬Longest-Living Organisms 🧵:
1. 🪸 Hexactinellid sponge: 15,000 yrs
2. 🌳 Great Basin bristlecone pine: 5,082 yrs
3. 🌳 African baobab: 2,500 yrs
4. 🪸 Epibenthic sponge: 1,550 yrs
5. 🌳 Common ginkgo: 1,000 yrs
People accept ageing as natural not because they don’t know what to do, but because as they get older & sicker, they struggle to imagine a future without disease.
We all agree #ageing will be solved someday, but we can’t yet imagine how or that we’ll be the ones making it happen!
Abundance mindset isn’t just philosophy, it’s a longevity science.
Optimists live 7.5+ years longer (Harvard data). It lower cortisol, creates stronger social bonds, and boosts neurochemical rewards from gratitude.
A good daily practice: Reframe scarcity → celebrate growth
Statistically we are mostly red blood cells and platelets (count: 80-90%) and they don't even have a nucleus. #BiologyIsWild #CellBiology
10/ This is quite significant because it decomplexes body temperature from basic metabolism or calorie restriction an often coupled mechanisms. These findings hint at a new therapeutic strategy to slow ageing and treat age-related diseases.
9/ When researchers separated the effects of reduced metabolism and calorie restriction from that of lower body temperature, only the drop in temperature significantly slowed epigenetic ageing. The bigger the drop, the slower the ageing process.
8/ More surprisingly, there was also an increase in DNA repair and antioxidant defences. Mice were not only molecularly younger, but they were physically healthier and functionally younger, as measured by the mouse frailty index.
7/ It is not only slowing down molecular ageing, but also increasing cellular resilience. Gene expression analyses showed the expected shift towards glucose metabolism and lipid synthesis typical of an animal in an energy conservation mode.
6/ Surprisingly, transcriptomic ageing clocks showed different results with significant slowing in the kidney and cortex as well, which were non-significant in the epigenetic ageing clocks. It also showed that there might be sex differences, with liver ageing being slower in females than in males.
5/ Different organs responded in different ways: blood epigenetic ageing slowed by about 80%, the liver by 20%. This means that the benefits of lower core temperature could be tissue specific.
4/ It’s long been observed that animals that hibernate tend to live longer than their non-hibernating relatives. Here, inducing torpor in mice slowed metabolism and lowered body temperature, which in turn slowed down their epigenetic ageing.
3/ New research from Nature Aging has shown how this works in practice. Researchers induced a hibernation-like state, or torpor, in mice that don't naturally hibernate by activating specific preoptic neurons using molecular techniques that could keep them hibernating for days and weeks.
2/ Lowering core body temperature was previously shown to slow cellular ageing by preventing protein aggregation and boosting protein quality control in cells. This is true for cold blooded animals as well as warm blooded animals, including mammals.
Imagine if we could safely harness the power of a lower core body temperature to slow ageing and treat age-related diseases. New findings suggest that cooling might be one of the most effective ways to extend healthspan. 🧵
There is no one way to read academic papers. Scientist value different sections of papers. I personally check figure legends and last paragraphs of Introduction and discussion.
Waiting for the Barbarians
This study finds a brain region in mice as the ageing hub, linking immune shifts to energy control. A step closer to decoding brain ageing! 🧠 #Science #Ageing
#DeSi 🚀
💬 What do you think 2050 will look like?
Follow for more insights on tech and the future! 🤖✨
8/8
Looking Back: People in 1995 were full of hope and awe making predictions sometimes naive, sometimes visionary.
It reminds us that the future is unpredictable, especially with the exponential development of technology. As Alan Kay said, "The best way to predict the future is to invent it." 🚀
7/8
Prediction: They envisioned VR holidays by 2024, with 40-minute shuttles to "Indo Disney" and AI assistants as holographic heads.
Reality: VR and smart speakers are real, but ultra-fast travel is still sci-fi.
6/8
Prediction: The show also imagined microchips implanted in arms for payments.
Reality: Biometrics like facial recognition and contactless payments dominate. Microchip technology exists but hasn’t become mainstream.
5/8
Prediction: Robots would perform surgeries by 2004, controlled remotely with “spatial gloves.”
Reality: Robots like Da Vinci assist surgeons today, but hologram patients? Not yet! That part remains science fiction.
4/8
