The first astronaut in history to speak French while en route to the moon — Canada’s very own Jeremy Hansen 🇨🇦

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.

We're excited to announced that our 2nd Annual QMUL Centre for Epigenetics Conference is happening on June 18th, 2026 at Mile End!

To find out more and book your ticket, please follow this link: www.qmul.ac.uk/epigenetics/...

The deadline to book your tickets is Monday, June 8th 2026.

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Pleased to share our new @natcancer.nature.com
paper, where we harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. This resource strengthens the foundation for liquid biopsy monitoring to enable better, earlier, less invasive care.

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

🌟New Resource article

Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients

✒️Yong Zeng, @matlupien.bsky.social, @pughlab.bsky.social, Housheng Hansen He & colleagues

www.nature.com/articles/s43...

Our researchers analyzed 1,294 blood samples from 11 cancer types to build a comprehensive atlas of DNA methylation patterns, advancing pan-cancer detection and monitoring through liquid biopsy.

Published in Nature Cancer: www.nature.com/articles/s43...
@uhnresearch.ca @uhn.ca

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Massive team-science effort across @pmresearch-uhn.bsky.social @uhnresearch.ca @uhn.ca @oicr.on.ca and collaborators (incl. TrevorPugh & Hansen He labs; lead author Yong Zeng).
www.nature.com/articles/s43...

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...

Pleased to share our new @natcancer.nature.com
paper, where we harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. This resource strengthens the foundation for liquid biopsy monitoring to enable better, earlier, less invasive care.

METTL3-based epitranscriptomic editing screening identifies functional m6A sites in cancers - Nature Cancer He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...

New study from Dr. Hansen Housheng He’s team, thrilled that we contributed, on functional mapping of m6A in cancer at scale with implications for novel target discovery and future therapeutic development. www.nature.com/articles/s43...

METTL3-based epitranscriptomic editing screening identifies functional m6A sites in cancers - Nature Cancer He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...

New study from Dr. Hansen Housheng He’s team, thrilled that we contributed, on functional mapping of m6A in cancer at scale with implications for novel target discovery and future therapeutic development. www.nature.com/articles/s43...

Our new study found that, when prostate cancer cells spread, they adopt an “inflammatory-like” state and mimic immune cells, suggesting new ways to control cancer progression.
Co-led by @matlupien.bsky.social @uhn.ca @uhnresearch.ca with @dkfz.bsky.social:
doi.org/10.1038/s414...

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.

Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination - Nature Communications Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...

Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...

Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.

Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination - Nature Communications Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...

Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

An integrated view of the structure and function of the human 4D nucleome - Nature The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!

www.nature.com/articles/s41...

Exciting new conference!

Our lab website just got a major refresh to better present:

Our research philosophy: why chromatin is central to our work.
A snapshot of our culture: diverse, collaborative, impact-driven.
Our priorities: how we translate discoveries into clinical reality.

Check it out

Cancer is fundamentally a complex, multifactorial disease, and research fields have grown from viewing cancer through different mechanistic lenses. 1.    Cancer as an immune-related disease. This… |... Cancer is fundamentally a complex, multifactorial disease, and research fields have grown from viewing cancer through different mechanistic lenses. 1.    Cancer as an immune-related disease. This vi...

www.linkedin.com/posts/mathie...

Our lab website just got a major refresh to better present:

Our research philosophy: why chromatin is central to our work.
A snapshot of our culture: diverse, collaborative, impact-driven.
Our priorities: how we translate discoveries into clinical reality.

Check it out

Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.

One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ

Français : L’image montre un vaste champ de coquelicots rouges éclatants sous un ciel sombre et orageux. Les fleurs, d’un rouge vif, contrastent fortement avec les tons gris et noirs du paysage environnant. Le soleil perce entre les nuages à l’horizon, projetant un rayon lumineux qui illumine certaines fleurs au premier plan. Les coquelicots, aux pétales ouverts et délicats, semblent danser doucement dans la lumière. L’atmosphère est à la fois dramatique et paisible — un moment suspendu entre la tempête et la sérénité, entre l’ombre et la lumière. English: The image shows a vast field of bright red poppies beneath a dark, stormy sky. The vivid red flowers stand out sharply against the gray and black tones of the surrounding landscape. The sun breaks through the clouds on the horizon, casting a beam of light that illuminates some of the poppies in the foreground. Their open, delicate petals appear to sway gently in the light. The overall mood is both dramatic and peaceful — a suspended moment between storm and calm, between shadow and light.

Lest We Forget
N'oublions Jamais

Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation YouTube video by theCrux

DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:

SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200 Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

Embryonic signatures of intergenerational epigenetic inheritance across paternal environments and genetic backgrounds | The EMBO Journal imageimagePaternal environmental exposures have been linked with modulation of phenotype and disease risk in offspring via largely unclear mechanisms. This study employs in vitro fertilization and sin...

❓Can a father’s environmental exposures before conception influence their offspring?

We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences

www.embopress.org/doi/full/10....

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Programmable epigenome editing by transient delivery of CRISPR epigenome editor ribonucleoproteins - Nature Communications Epigenome editing programs gene silencing without inducing DNA breaks but challenges in delivery into human cells limit its broader use. Here, the authors present the RENDER platform, which uses virus...

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...