Pupil dilation is an established biomarker of arousal, and studies have shown that non-invasive vagus nerve stimulation (taVNS) elicits pupil dilation. Here, we find that it depends on sensory matching.
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Effects of non-invasive vagus nerve stimulation on pupil dilation are dependent on sensory matching www.biorxiv.org/content/10.1101/2025.06....
Our meta-analysis showed tVNS-induced pupil dilation (neuromadlab.shinyapps.io/tVNSPupilmeta/). We wanted to replicate with right-sided tVNS, but when accounting for sensation (even with initial matching) there was no effect compared to sham in our sample (N=94).
www.biorxiv.org/content/10.1...
This is the first paper of my first grant ๐. Work led by our PhD-student @cecivez.bsky.social together with @ulrichettinger.bsky.social & @nbkroemer.bsky.social
There is also good news embedded in the report. We find that taVNS briefly purturbs the correlation of the pupil dilation trace of the left and the right eye. This novel marker is not as strongly associated with sensory ratings. But it makes sense since we stimulate one side of the vagus.
A plot showing that taVNS does not induce larger pupil dilation compared to sham.
A plot showing that sham-induced pupil dilation is much more variable
Pulsed taVNS elicits pupil dilation. However, if sham feels as intense, there is not much left. Based on our comparatively large sample (94 participants, single-blind crossover), we show that a highly variable sham response explains this.
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www.biorxiv.org/content/10.1...
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Want to learn more about these truly eye-opening findings? You can run your adjusted meta-analysis using our living Bayesian meta-analysis, which is provided as a ShinyApp. Check it out here:
neuromadlab.shinyapps.io/tVNSPupilmeta/
Across 18 studies, the meta-analysis shows moderate evidence against an effect of taVNS on pupil dilation
Stimulation effects of taVNS on pupil dilation depend on the use of a phasic vs. conventional protocol.
Does tVNS elicit replicable effects beyond BOLD responses in the brainstem? Yes, pulsed, but not conventional tVNS leads to robust pupil dilation in our new meta-analysis.
Published in Brain Stim w/ @cecivez.bsky.social @akuehnel.bsky.social #neuroskyence ๐ฉบ
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In search of markers of tVNS, we looked at pupil dilation ๐๏ธ doi.org/10.1101/2024... . Short pulsed but not continuous stimulation seems to work! You can also look at the data yourself neuromadlab.shinyapps.io/tVNSPupilmeta/. work w/@nbkroemer.bsky.social & @cecivez.bsky.social ๐ง
After months of piloting and optimization, we are finally seeing high-quality recordings of tVNS-induced pupil dilation. @akuehnel.bsky.social also set up an automated QC report with several plots and is too humble to brag about it.
Work w/ @cecivez.bsky.social #neuroscience
Such an inspiring WISE luncheon hosted by @therealspr.bsky.social today. Thanks to the speakers for sharing their experiences on how to build a more inclusive and diverse environment in academia. Great food for thoughts on how we as students and ECRs can also contribute! #2023SPR
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Looking forward to the next few days of talks, posters and social events, and to presenting some of our recent work on taVNS and decision-making on Friday!
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Out now in Nature Metabolism: metabolic tuning during the menstrual cycle.
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Out now in PLoS Digital Health:
Reward learning parameters are often seen as trait-like characteristics. We collected >9.7k runs of a gamified task to estimate reliability and find considerable fluctuations. Work w/ @akuehnel.bsky.social #neuroskyence #MedSky
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