Figure 2. FORCE1s reports in vivo neuronal activity with high fidelity under resonance scanning 2-photon microscopy (A-I) 2P-guided whole-cell patching and resonant-scan imaging in anesthetized mice. (A) Experimental schematic. (B) 2P images of a representative FORCE1s-Kv-expressing neuron are shown at high resolution (i) and the size and resolution used during voltage imaging (ii). The patching pipette is outlined. (C) Simultaneous electrophysiological recording (top, 10 kHz) and FORCE1s-Kv fluorescence imaging (bottom, 440 Hz). The fluorescence trace was low-pass filtered at 150 Hz to enhance the visualization of the spikes. Dashed boxes: epochs shown in panels D-E. Vertical lines: detected spikes. Gray triangle (left, and in panels D-E): -70 mV. (D-E) Zoomed-in subthreshold (D) and bursting (E) epochs. Panel D’s optical trace was low-pass filtered at 50 Hz to enhance the visualization of subthreshold fluctuations.

This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.

Also not a native speaker, but to me "no worries" only implies that your refusal to attend committee meeting x does not cause any issues, since another victim has already been identified.

Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

Excited to share our new J Neurosci paper showing how subcortical inputs are routed through ventromedial (VM) thalamus to layer 1 interneurons in the medial PFC, all done by my graduate student Sanne Casello:
sannemcasello.bsky.social
www.jneurosci.org/content/earl...

What are the systems in neuroscience that we really have something that we can call “explanation” at all relevant levels, other than reflexive feed-forward like circuits.

Here are a few that I would argue are getting there. Obviously not complete explanations but genuinely satisfying.

Fluorescent image of a mouse organ of Corti. Teal and pink labeling shows N-cadherin and E-cadherin in the inner and outer compartments respectively. Yellow labels the hair cells and their stereociliary bundles. Contact me about postdoc opportunities related to this work!

Postdoc @ Emory Univ.
The Deans lab is recruiting postdocs to work on inner ear development, hair cells and innervation. We use mouse genetics, imaging, and dev bio to understand how the machinery for hearing + balance is built.
Email a CV and brief statement of interests.
🔁 Boosts appreciated

Inhibitory neurons differentially control sound-evoked responses in the MGB. Left: diagram of the proposed circuit underlying our results. Boxes: summary of effects of optogenetic manipulation of SSTTRN (top) or PVTRN (bottom) inactivation on MGB firing and the circuitry and results of computational models that support a similar distribution of effects.

The medial geniculate body #MGB in the #auditory #thalamus is a key early node in sound processing. @geffenlab.bsky.social &co show in mice that two inhibitory neuron types have distinct connectivity & effects on sound processing. @plosbiology.org 🧪 plos.io/47twOtM

Ein historischer Moment: 65 Jahre nachdem der erste türkische Gastarbeiter nach Deutschland kam, wird mit @oezdemir.de erstmals ein türkeistämmiger Deutscher Ministerpräsident von Baden-Württemberg.
Das erfüllt mich mit Stolz auf dieses Land. Glückwunsch an Ba-Wü und Cem!

Happy to share our new study about how cortical and thalamic inputs engage cholinergic interneurons in the nucleus accumbens (NAc) core, all done by my graduate student Emily Jang:
www.biorxiv.org/content/10.6...

Have said this before in other forms, but will reiterate it here: if you're doing long-form writing of any sort, reading the words aloud into a microphone is a completely unparalleled cheat code. It's free, easy, and so effective it feels like it shouldn't be allowed. I do it in a few stages...

Train booking in Germany!

UAB is recruiting neuroscience faculty at two different levels - come join our vibrant neuroscience community!

I think this is a *super* important paper - if this result can be replicated with other regions or tasks then this may come to form our core understanding of credit assignment signals in the neocortex!

#neuroscience 🧪

As new Kopchick Fellows are named, we are sharing a brief series highlighting the leadership and impact of the fellowship. Our first features the Kopchicks, Huda Zoghbi, MD, and Fellow, Stephen Farmer, whose neurodegenerative disease research continues this fall in the Huda Zoghbi Lab. More to come.

Over the last few years, they won against Roma (twice), Celtic, Zagreb, Besiktas, Lazio, Man City, Man United, Atletico Madrid, and now Inter. This ain't no Appalachian State. This is a really good team.

Today, I would like to honor the memory of Roger Y. Tsien, born on February 1, 1952. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday
www.nature.com/articles/nme...

Lyon fans held up this banner during a poignant minute's silence before their game vs. PAOK 🖤

Seven fans of the Greek club were killed in a minibus crash en route to the Europa League tie.

Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!

Listening to a discussion about AI in university education with Amol Rajan & Prof Duncan Iveston on Radio 4 Today. Too short to get into the nuance of course, but an observation that copilot can do a literate review for you very quickly perfectly illustrates one of my main concerns with AI…1/1

1. If the goal is to stop us from doing science, then doing science is more important than ever now.
2. We have radical uncertainty about the future. There is no sense in giving up in advance.
3. We have agency over the future. If you don't like what's happening, work to change what is happening.

Tracking the details of an experiment in successively cited Methods sections

Excited to share our new study showing how subcortical inputs are routed through ventromedial (VM) thalamus to layer 1 interneurons in the medial PFC, all done by my graduate student Sanne Casello:
sannemcasello.bsky.social
www.biorxiv.org/content/10.6...

Hiking and Camping in Great Sand Dunes National Park | sand & snow YouTube video by Meredith

Went on a short backpacking trip as I was finishing up my thesis last December. Compiled some of the footage into a YouTube video :)

We were at the great sand dunes in Colorado- so much snow! and sand! and wind! ❄️⏳⌛️

We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n

when doing neuroscience projects I often advocate for computational modelling, followed by data analysis to test model's predictions.

however a few times now I have had pushback from collaborators/reivewers suggesting it would be better to do the data analysis first, then the modelling.

thoughts?

Apply ad

Apply to the Neurobiology course at MBL! It is supercool. Apps due Feb 4.

Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.

The Neural Systems & Behavior Course (Marine Biol. Lab) is an amazing opportunity to learn about many different approaches to studying nervous system control of many behaviors. Learn from experts, expand your science network, go to "science summer camp"!

We've got a great lineup of speakers for our Thalamocortical Interactions GRS! Only a few spots remaining for poster presenters - apply soon!

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...