Autologous human iPSC–derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection An autologous, genetically tractable human iPSC–derived alveolar model is developed to study tuberculosis.

Read more:
www.science.org/doi/10.1126/...

🔬Modeling early Host-Pathogen interactions between human and Mycobacterium tuberculosis.
🧫Study the functions of genes in a cell type-specific manner.
🌬️Study host responses against different foreign air-borne particles.
💊Drug toxicity testing and development
Personalised medicine.

We are able to:
🫁Recreate alveolar epithelial and endothelial barriers on chip.
⚖️Achieve a balance of alveolar cell types.
🧫Show the complex multicellular composition changes cell status.
🧬Build lung-on-chip with genetic manipulation in specific cell type.
☠️Recapitulate early Tuberculosis hallmarks.

An amazing team of interdisciplinary scientists The Francis Crick Institute and AlveoliX is behind this piece of work generously supported by @wellcomeleap.bsky.social HOPE - Human Organs, Physiology, and Engineering Program.

I am thrilled to share that the work from @maxgg.bsky.social team @crick.ac.uk engineering a lung-on-chip from human iPSC is published in #ScienceAdvances @science.org in the new year.

Built to breathe: mini ‘lungs’ recreate individual response to infection Lung-on-chip device exposes earliest stages of tuberculosis infection, and opens doors to investigate diversity in disease progression and personalised treatment.

Lab-grown lung models have traditionally been grown from a mixture of cells, making it hard to tell how a disease or treatment will affect an individual person.

These new models by @maxgg.bsky.social’s team and AlveoliX are grown from a single person’s stem cells ⤵️ www.crick.ac.uk/news/2026-01...

Former Taiwan leader was due to visit UK for two days in October, leak shows Exclusive: letter reveals dates for visit that was planned by Tsai Ing-wen before Foreign Office intervened

Keir Starmer and the Labour party refused to condemn the people’s court ruling of the Hong Kong 47, intervened the visit of former 🇹🇼 president to kowtow to 🇨🇳. Not sure if the labour is serving the 🇬🇧 voters or President Xi Jingping. www.theguardian.com/politics/202...