Oof

It looks good homie

It’s SUCH a good show

I’m definitely watching and hoping for the McDavid outcome 🤣

Yikes!

Great movie choice tho

Vaccines work.

Those questions right after his skate were so cringy. 😕

Yeah, one of the best 🤣

I didn’t have whatever it was on my feed 🤷‍♂️

That was a long formation salute 😩

Every American needs to watch this:

Should we post library stats? 🤣

a close up of a man 's face with the words `` nice '' written on it . ALT: a close up of a man 's face with the words `` nice '' written on it .

Oooooo

I miss wearing my Timex Expedition (stupid Apple Watch 😡)

a baby wearing a penguins jersey holds up his fist in the air ALT: a baby wearing a penguins jersey holds up his fist in the air

I’m so excited to binge watch the season over the weekend

I grew up with Alex Pretti The kind-hearted ICU nurse shot by ICE agents was my childhood best friend.

I wrote about my childhood friend Alexi Pretti. Please read it and share it and remember him as a human being. @theverge.com

Same. SAME.

Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible.

Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.

Graphical Abstract (CREDIT: Cell Reports Medicine)

In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️

CISM is my next cert. Any tips/tricks in the learning path? Did you attend a boot camp or similar?

Great job!

I made a bot that will post "National Lampoon's Christmas Vacation," clip by clip, between now and Christmas Eve. That's 12–13 clips daily, 24/7, just so you know what you'd be getting into. (Clips will auto-delete a few days after being posted.) It starts now.

What if the United States had high-speed rail? High-speed rail is a proven alternative to gridlocked highways and overcrowded airports. CNN has reimagined a faster, more connected future for US commuters.

This is such a cool breakdown I can’t believe CNN did something this rad

Exactly. We need a fucking break.

Haha that tracks with my experience.

Have you noticed a difference between NG and AR folks? Or basically the same?