S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis - Communications Chemistry Ribosomally synthesized and post-translationally modified peptides (RiPPs) require precise proteolytic cleavage to generate bioactive natural products, yet the diversity of serine proteases involved r...

We discovered an uncharacterized serine protease, WprP catalyzes uniform cleavage on the precursor peptides. The cleavage activity has not been seen in any serine proteases in RiPP biosynthesis | Communications Chemistry
doi.org/10.1038/s420...

Cyanobacterial Cyclic Peptides Containing cis‐Pro Conformation Cyanobacterial cyclic natural products are ribosomal or nonribosomal peptides, typically containing one or more proline residues. However, the presence and population of the cis-Pro conformation are ....

Many cyanobacterial cyclic peptides contain one or more Pro residues. However, the presence and populations of cis-Pro conformation is not always explicitly stated in the literature.

We co-writing a review on this topic with Prof. Christopher R. Coxon | Chem Eur J
doi.org/10.1002/chem...

P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides Cytochrome P450 enzymes install C–C, C–N, or C–O cross-links on the precursor peptides of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, we bioinformatically mapped ...

Happy to share our work on cross-linking enzyme KwwB catalyzes Trp-C5–Trp-N1 cross-linking and accepts diverse precursor peptides | Organic Letters
doi.org/10.1021/acs....

Contributors to the 2025 RSC Chemical Biology Emerging Investigators Collection This article profiles the early career researchers whose work features in the RSC Chemical Biology Emerging Investigators Collection 2025.

Honored to be one of the 2025 RSC Chemical Biology Emerging Investigators
doi.org/10.1039/D5CB...

Honored to give a presentation at Nanyang Technological University. Thanks to Prof. Zhao-Xun Liang for hosting me.

Marine Natural Products from Malaysia Marine natural products are a rich source of chemically diverse and biologically active molecules. Over two decades (2001–2024), a total of 228 marine natural products have been reported from soft corals, red algae, sponges and cyanobacteria collected in...

Happy to share our invited book chapter on marine natural products from Malaysia, Springer, 2025, pp 183-225 (doi.org/10.1007/978-...). Submission invited by Prof. Lik Tong Tan (NTU Singapore). Supported in part by EU project No. 101087181.

Dear Prof Katherine Duncan, I am Chin-Soon working on microbial natural products at Northern Europe, Latvia. I will happy to join and learn the group you created.

P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide Biarylitides are a new class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with the unique feature of biaryl C–C, C–N, or C–O cross-links installed by P450 biarylitide ...

Happy to share our recent works on cross-linking enzymes, ShyB and MpoB involved in RiPP biosynthesis | Organic Letters doi.org/10.1021/acs.... | RSC Chemical Biology doi.org/10.1039/D5CB...

We are organizing our second workshop in this June at Riga with four Invited Speakers, Yvain Nicolet, Robin Teufel, Joleen Masschelein and Florian Hubrich.

Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide Cross-link containing products from ribosomally synthesized and post-translationally modified peptides (RiPPs) are generated by radical SAM enzymes (rSAM). Here, we bioinformatically expanded rSAM enz...

Happy to share our first independent work. We studied radical SAM enzyme, WprB catalyze Trp-to-Arg crosslink | ACS Chem Biol
doi.org/10.1021/acsc...