NASA's Artemis II Live Mission Coverage (Official Broadcast) YouTube video by NASA

It's GO 🚀 Godspeed NASA and Artemis II 😊https://www.youtube.com/watch?v=m3kR2KK8TEs

We found a new brain shuttle! Mucins on brain endothelium mediate transcytosis of cargo linked to mucin-binding “C domain”. Congratulations Sophia Shi, now a Roland Fellow @harvard.edu, and longtime collaborator Tony Wyss-Coray @stanfordmedicine.bsky.social

www.biorxiv.org/content/10.6...

This image illustrates how combining perennial genes with prostrate growth genes allows cultivated rice to mimic wild rice.

Wild rice is a perennial, creeping plant. The secret to its perennial growth habit lies in a developmental reversal directed by small RNAs. This image illustrates how combining perennial genes with prostrate growth genes allows cultivated rice to mimic wild rice.

Learn more: https://scim.ag/40GOjDb

🧵 1/8 Hot off the press! 🔥 link.springer.com/article/10.1...

CAR-T cells show promising results in preclinical glioblastoma models, yet clinical benefit in patients has been limited. To understand why, we used a human brain slice model that preserves the native human GBM tumor microenvironment. 🧠

Impressive work Yahaya 👍

How to Design Antibodies A step-by-step guide to making de novo binders.

comprehensive guide with background, approach and tools to design an antibody from scratch www.asimov.press/p/antibody-d...

Interesting and impactful 👏 💎

Good concept but 🙅 and would rather prefer in-built global and project specific memory files. code.claude.com/docs/en/memory For detailed history, safer to grep/rg ~/.claude/ over exposing unwarranted APIs. Worth noting potential security risks (C1, C2). github.com/thedotmack/c...

How I Tamed Claude - Emmz Rendle - NDC London 2026 YouTube video by NDC Conferences

Claude 101: An excellent primer and best practices doing agentic (and NOT vibe) coding I have seen around. via @rendle.dev www.youtube.com/watch?v=pey9...

Worth a read

Join @eunhee-yi.bsky.social lab if curious about ecDNA in cancer evolution and doing impactful science with cordial PI 🚀🫰

Ep 23 - So what actually IS CellPainting anyway? You may have heard of it if you're say, a fan of the @drannecarpenter.bsky.social - @shantanu-singh.cc lab (and who isn't????), but what, you know, is it? Let @erinweisbart.bsky.social break it down for you!

youtu.be/9-d6DoHtgUY

Deep Learning with Python, Third Edition Deep Learning with Python is written for anyone who wishes to explore deep learning from scratch. This new edition adds comprehensive coverage of generative AI and modern deep learning frameworks. It ...

Come learn about deep learning with us! The Data Science Learning Community just started reading the free third edition of Deep Learning with Python. Meetings are Tuesday at 3 pm CST.

DSLC: dslc.io
Book: deeplearningwithpython.io

#rstats #pydata

last but not least one on in vivo base editing in mice models of prion (PRNP) disease achieved 50% reduction in PrP protein and 52% increase in lifespan.

www.nature.com/articles/s41...

www.cell.com/cell/fulltex...

On how ~neutrally evolving CAG repeats over the lifespan eventually exerts neurodegenerative phenotype in Huntington’s disease.

pubmed.ncbi.nlm.nih.gov/40044858/

On early origin and maintenance of WGD despite (instability driven) fitness cost an organism has to endure.

All right it’s time for the annual “please tell us about one (or a few if you are ambitious) paper from 2025 that really impressed you and why we should all read it“! Go! If you tell us how it changed your view of the world and what makes it so powerful and consequential It would be excellent.

Functional modules predict cancer-relevant genetic interactions in mammalian cells Genetic interactions can reveal gene function and identify cancer-relevant synthetic lethals, but systematic mapping in human cells is constrained by inefficient reagents, vast combinatorial search sp...

Merry Christmas, genetic interaction nerds:

www.biorxiv.org/content/10.6...

Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !

👏 @broadinstitute.org "in mice AND humans"

gReLU: a comprehensive framework for DNA sequence modeling and design - Nature Methods gReLU advances deep-learning-based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications.

gReLU advances deep learning based modeling and analysis of DNA sequences with comprehensive toolsets and versatile applications. @avantikalal.bsky.social @gokcen.bsky.social

www.nature.com/articles/s41...

Diwali - festival of lights Clay, Photograph by Nah Ting Feng, Dreamstime. From https://kids.nationalgeographic.com/pages/article/diwali: lamps symbolize the inner light that protects each household from spiritual darkness.

तमसो मा ज्योतिर्गमय From darkness, lead me to the light.

Focus on the good and let the year be an act of random kindness.

Happy Diwali 🪔

Liquid Biopsy TGT September Podcast Episode · TGen Talks · 09/30/2025 · 26m

podcasts.apple.com/us/podcast/l...

@florisbarthel.bsky.social and team on liquid biopsy for brain tumors 💪

Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance Telomeres are essential for genome integrity, but the accurate, high-resolution mapping of their three-dimensional (3D) chromatin interactions, a process thought to mediate gene regulation and telomer...

This 7-year journey has reached a first milestone! 🥳 Excited to share our preprint (3rd of 2025) on the 3D telomeric interactome, a project that started with a K99 in 2018. Thanks to Yi-An Chen, first postdoc in our lab and first author who worked tirelessly to realize this dream. bit.ly/3W3wuMk

Characterising cancer-stroma interactions through high-content phenotyping from microscopy time-lapses www.biorxiv.org/content/10.1101/2025.10....

Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.

If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.

will go with second for Chemistry prize and would add Shankar Balasubramanian

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

@jeffgenome.bsky.social from ❤️ @jacksonlab.bsky.social at YaleMed grand rounds

Episode 11 - In which @erinweisbart.bsky.social and I talk about just how much we love ilastik (@ilastik-team.bsky.social) and how it's great for so many problems! Also, that you should use a small brush.