🧵 PCA is everywhere in bioinformatics—but did you know it’s just SVD in disguise?

1/ If you've done bioinformatics, you've likely used PCA. But did you know Singular Value Decomposition (SVD) is at its core? Let’s break it down. 👇

🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.

I ran a 'intro to single cell' workshop of one. Lol. It had been scheduled at a conference that drew a different audience, I got pulled in when the initial presenter couldn't present. Worked out alright, me and the attendee just stat together and chatted about the tech for a bit.

Your lab scissors are actually a parafilmase - a highly specialized enzyme that catalyzes the precise cutting of parafilm through a metal-dependent mechanism

Thanks - that is also of interest! (And python ecosystems have been sneaking up on me ever closer)

Something to investigate - I tend to work in workflowr/rnotebooks and rebuilding each stage is getting old