Leveraging Viscosity to Unlock the Osteogenic Potential of BMP‐2 Mimetic DWIVA Dynamic interfaces based on supported lipid bilayers demonstrate that the osteogenic potential of the BMP-2 mimetic DWIVA can be harnessed by modulating substrate viscosity. This work highlights that....

Interested in #Mechanobiology #BoneRegeneration and #GrowthFactor mimetics? Check out our paper in Small @wileyonlinelibrary.bsky.social by @finbariii.bsky.social. We show that viscosity unlocks the osteogenic activity of BMP-2 mimetic DWIVA @theglasgowcemi.bsky.social @uofgengineering.bsky.social 🧪

Huge collaborative effort from researchers at @ciber @upv.es @unizar.es @hospitallafe

The use of injectable alginate hydrogels for controlled local borax release enhanced muscle repair, reduced muscle atrophy and neuroinflammation, delayed symptom onset, and improved motor function and survival.
These findings highlight the therapeutic relevance of skeletal muscle in ALS as a target.

Injectable borax-loaded alginate hydrogels reduce muscle atrophy, modulate inflammation, and promote neuroprotection in the SOD1G93A mouse model of ALS through mechanisms involving IGF–Akt–mTOR signal... Amyotrophic Lateral Sclerosis (ALS) is a prevalent condition characterized by motor neuron loss and skeletal muscle paralysis. Despite being associate…

Hot off the press from the Centre Biomaterials 🧫🔬

Our latest research paper in the International Journal of Biological Macromolecules introduces
a novel muscle-targeted approach for amyotrophic lateral sclerosis (ALS) therapy in the SOD1G93A mouse model.

www.sciencedirect.com/science/arti...