Honored to have two images from our lab selected among the Top 5 Research Images of the Year in Göttingen 🎉

The images will be exhibited in Forum Wissen until 10 April 2026.

www.forum-wissen.de/event/resear...

#ForumWissen #ScienceIsAlsoArt

The image, which Mette (@metteh-thorsager.bsky.social) named “Democratising Imaging of Life in the Ocean,” features the salp Thalia democratica. It was captured with our portable Flamingo light-sheet microscope at @biodev-vlfr.bsky.social in collaboration with Alexandre Alié.

#Salp #LBDV

Lisa’s picture (@lisma-ulb.bsky.social), named “Where Science meets Art,” shows a transgenic line of the annelid worm Platynereis dumerilii. These worms were kindly provided by Guillaume Balavoine (@balavoinelab.bsky.social).

#PlatynereisDumerilii #Annelid
Photo credit: Yourong Frank Wang

Being portable, we could bring the Flamingo light sheet microscope to the exhibition opening to explain how we captured the Salp image.

This event shows that scientific research also reveals the beauty of the organisms we study.

#LightSheet #LSFM #PortableMicroscope #Flamingo
Photo credit: YF Wang

We advocate for model-guided, representative sampling and visualizations that make biological variation tangible.

Image showing two different views of the cochlea of a human inner ear shown on a black background with bright, detailed turquoise images and violet colours. The image is very clear and detailed. It was created using the new light sheet fluorescence microscopy platform developed by researchers. The image is adapted from Aakhte, M. et al., Nature Biotechnology, DOI: 10.1038/s41587-025-02882-8; openly licensed via CC BY 4.0

Faster, clearer, deeper 3D imaging

Researchers developed an innovative light sheet fluorescence microscopy platform, which means detailed scans of fine networks of nerves or blood vessels are possible faster: www.uni-goettingen.de/en/3240.html...

#NatureBiotechnology: doi.org/10.1038/s415...

Hörschnecke eines menschlichen Innenohrs sichtbar gemacht mit dem neuartigen Lichtblatt-Fluoreszenzmikroskop © Adaptiert nach Aakhte, M. et al., Nature Biotechnology, DOI: 10.1038/s41587-025-02882-8; lizensiert nach CC BY 4.0

Lichtblattmikroskope erstellen 3D-Scans von Geweben und Organen – erzeugen bei großen Proben aber unscharfe Bilder. Forschende haben eine Plattform entwickelt, die diese Hürde überwindet. Mehr erfahren: www.uni-goettingen.de/de/3240.html...

#MBexC #UMG @mbexc.bsky.social @huiskenlab.bsky.social

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue Nature Biotechnology - A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

Absolutely loved this paper. Really addresses my personal gripes of not having isotropic voxel size in microscopy imaging

rdcu.be/eRgYm

Rendering of a full cochlea (left) with three stains (PV, VGlut3, CTBP2) shown in three different colors (red, blue, cyan). The whole cochlea is a spiral shaped structure, with spiral ganglion neurons (SGNs) in the inner helix, labeled by PV and inner hair cells (IHCs) in the outer helix, labeled by Vglur3. The figure also shows zoom ins. The right hand side shows segmentation results for SGNs, IHCs (represented by colored masks) and synapse detections (represented by colored dots).

Preprint alert! CochleaNet, our framework for analyzing light-sheet data of the cochlea. It consists of three networks to segment spiral ganglion neurons, inner hair cells, and to detect synapses. See rendering of a full cochlea in the image, find the preprint at doi.org/10.1101/2025....

Studying cochlear neuroanatomy demands imaging the entire cochlea at subcellular resolution. In our recent study (tinyurl.com/isotropicLSFM), we recorded the cochlea at isotropic resolution across the whole organ, laying the groundwork for what follows…

#lightsheet
#isotropic
#cochlea

For technical details see the following post:

Very happy to share our latest work extending iterative immunofluorescence to in toto imaging of early zebrafish embryos (3D-4i), integrated with a 3D-dedicated image analysis pipeline! 🐟🔬📊
Huge kudos to Max Hess for this PhD milestone! 💪
@lucaspelkmans.bsky.social shorturl.at/cO0u7
Let's zoom in!

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

I am happy to share a recent collaboration with @huiskenlab.bsky.social and @aakhte.bsky.social , who developed a great technique for performing fast and, above all, isotropic light-sheet microscopy. www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

🎉 I am very glad to share that our paper on the rapid isotropic light-sheet microscope has just been published in Nature Biotechnology @natbiotech.nature.com.

🔗 Read the full article:
www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

www.nature.com/articles/s41...

Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social
www.nature.com/articles/s41...

#microscopy #lightsheet

High-speed isotropic light-sheet microscopy - Nature Biotechnology Achieving uniform, isotropic sub-micrometer-resolution imaging at high speed across large, cleared tissues has been a major challenge for light-sheet microscopy. To address this, we developed a cost-e...

Research Briefing: High-speed isotropic light-sheet microscopy www.nature.com/articles/s41...
rdcu.be/ePWjG

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - @huiskenlab.bsky.social go.nature.com/4odcS49

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy Modern biology increasingly depends on data-driven discovery, requiring scalable and affordable high-content 3D imaging across molecular to organ scales. Although tissue clearing, expansion microscopy...

Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy
www.biorxiv.org/content/10.1...

Our image of a sea squirt oozoid (Thalia democratica) was selected as an Image of Distinction in Nikon Small World. Imaged with the Flamingo microscope by @metteh-thorsager.bsky.social at @biodev-vlfr.bsky.social in Villefranche-sur-Mer. Salp sample courtesy of Alexandre Alie.

nikonsmallworld.com/

The future of High-Content Imaging has arrived.

-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!

See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...

The Göttingen Cognition Forum: Curiosity & Interaction We are pleased to announce the First Göttingen Cognition Forum: Curiosity & Interaction The conference brings together researchers from neuroscience, psychology, behavioral biology, computational scie...

Huisken lab is attending Göttingen Cognition Forum: Curiosity & Interaction. Learn about our research...

@spp2205.bsky.social @sfb1528.bsky.social @rtg2906-curiosity.bsky.social

@uni-goettingen.de events.gwdg.de/event/1099/

Postdoc opportunity in the Averof lab: a crustacean meets a flamingo—not on the menu, but in the light sheet. Track the origins of cells during leg regeneration in Parhyale hawaiensis using light sheet microscopy. Excited to be part of this interdisciplinary project. Details on how to apply below.

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

The Huisken lab is now on Bluesky @huiskenlab.bsky.social - follow us for updates on our activities!

We brought our Flamingo microscope to the light sheet microscope course in Dresden (#LISH25). We captured extensive time-lapse recordings and are excited to share highlights from our experiments with Hydra and Zebrafish.

#biabob 0.28.0 is out and it comes with support for OpenAI's codex-mini model. I also enabled its vision-support. With this, you can turn screenshots of user-interfaces into functional code - directly within your Jupyter notebook 🤯
github.com/haesleinhuep...

We are excited to share our development of a new 10X lens with NA=0.50 over a 7.2 mm FOV and a 35 mm working distance (water), fully corrected from 400-850 nm. This lens will power our upcoming ExA-SPIM "2" and is available for dissemination - please get in touch if interested!

Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now:

opg.optica.org/boe/fulltext...

Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n